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Gene: PTDSS1 |
Gene summary for PTDSS1 |
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Gene information | Species | Human | Gene symbol | PTDSS1 | Gene ID | 9791 |
Gene name | phosphatidylserine synthase 1 | |
Gene Alias | LMHD | |
Cytomap | 8q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006575 | UniProtAcc | P48651 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9791 | PTDSS1 | LZE2T | Human | Esophagus | ESCC | 2.08e-09 | 1.47e+00 | 0.082 |
9791 | PTDSS1 | LZE4T | Human | Esophagus | ESCC | 3.60e-32 | 1.47e+00 | 0.0811 |
9791 | PTDSS1 | LZE7T | Human | Esophagus | ESCC | 1.11e-08 | 6.50e-01 | 0.0667 |
9791 | PTDSS1 | LZE20T | Human | Esophagus | ESCC | 3.80e-05 | 3.27e-01 | 0.0662 |
9791 | PTDSS1 | LZE24T | Human | Esophagus | ESCC | 8.34e-27 | 8.05e-01 | 0.0596 |
9791 | PTDSS1 | LZE21T | Human | Esophagus | ESCC | 2.37e-09 | 6.16e-01 | 0.0655 |
9791 | PTDSS1 | LZE6T | Human | Esophagus | ESCC | 4.98e-05 | 2.03e-01 | 0.0845 |
9791 | PTDSS1 | P2T-E | Human | Esophagus | ESCC | 2.36e-31 | 5.83e-01 | 0.1177 |
9791 | PTDSS1 | P4T-E | Human | Esophagus | ESCC | 1.14e-22 | 8.30e-01 | 0.1323 |
9791 | PTDSS1 | P5T-E | Human | Esophagus | ESCC | 5.39e-23 | 7.29e-01 | 0.1327 |
9791 | PTDSS1 | P8T-E | Human | Esophagus | ESCC | 1.50e-19 | 1.66e-01 | 0.0889 |
9791 | PTDSS1 | P9T-E | Human | Esophagus | ESCC | 3.55e-32 | 9.85e-01 | 0.1131 |
9791 | PTDSS1 | P10T-E | Human | Esophagus | ESCC | 6.16e-43 | 8.14e-01 | 0.116 |
9791 | PTDSS1 | P11T-E | Human | Esophagus | ESCC | 4.05e-16 | 8.93e-01 | 0.1426 |
9791 | PTDSS1 | P12T-E | Human | Esophagus | ESCC | 2.59e-36 | 8.76e-01 | 0.1122 |
9791 | PTDSS1 | P15T-E | Human | Esophagus | ESCC | 7.14e-39 | 9.33e-01 | 0.1149 |
9791 | PTDSS1 | P16T-E | Human | Esophagus | ESCC | 3.16e-51 | 1.06e+00 | 0.1153 |
9791 | PTDSS1 | P17T-E | Human | Esophagus | ESCC | 2.60e-02 | 3.02e-01 | 0.1278 |
9791 | PTDSS1 | P19T-E | Human | Esophagus | ESCC | 6.89e-07 | 6.92e-01 | 0.1662 |
9791 | PTDSS1 | P20T-E | Human | Esophagus | ESCC | 1.45e-15 | 3.69e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
GO:00464744 | Esophagus | ESCC | glycerophospholipid biosynthetic process | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:00450175 | Esophagus | ESCC | glycerolipid biosynthetic process | 154/8552 | 252/18723 | 5.20e-07 | 6.96e-06 | 154 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:00066505 | Esophagus | ESCC | glycerophospholipid metabolic process | 174/8552 | 306/18723 | 4.92e-05 | 3.85e-04 | 174 |
GO:00065757 | Esophagus | ESCC | cellular modified amino acid metabolic process | 112/8552 | 188/18723 | 8.31e-05 | 6.06e-04 | 112 |
GO:00423986 | Esophagus | ESCC | cellular modified amino acid biosynthetic process | 34/8552 | 46/18723 | 9.39e-05 | 6.70e-04 | 34 |
GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
GO:000657521 | Liver | HCC | cellular modified amino acid metabolic process | 119/7958 | 188/18723 | 6.47e-09 | 1.67e-07 | 119 |
GO:00086542 | Liver | HCC | phospholipid biosynthetic process | 150/7958 | 253/18723 | 4.77e-08 | 1.03e-06 | 150 |
GO:00066444 | Liver | HCC | phospholipid metabolic process | 214/7958 | 383/18723 | 7.25e-08 | 1.48e-06 | 214 |
GO:004648611 | Liver | HCC | glycerolipid metabolic process | 215/7958 | 392/18723 | 4.54e-07 | 7.49e-06 | 215 |
GO:004501711 | Liver | HCC | glycerolipid biosynthetic process | 143/7958 | 252/18723 | 3.27e-06 | 4.31e-05 | 143 |
GO:00066504 | Liver | HCC | glycerophospholipid metabolic process | 168/7958 | 306/18723 | 7.27e-06 | 8.62e-05 | 168 |
GO:004647411 | Liver | HCC | glycerophospholipid biosynthetic process | 121/7958 | 211/18723 | 9.12e-06 | 1.06e-04 | 121 |
GO:004239821 | Liver | HCC | cellular modified amino acid biosynthetic process | 34/7958 | 46/18723 | 1.53e-05 | 1.67e-04 | 34 |
GO:00086543 | Oral cavity | OSCC | phospholipid biosynthetic process | 130/7305 | 253/18723 | 3.96e-05 | 3.46e-04 | 130 |
GO:00423985 | Oral cavity | OSCC | cellular modified amino acid biosynthetic process | 31/7305 | 46/18723 | 9.03e-05 | 6.88e-04 | 31 |
GO:00464743 | Oral cavity | OSCC | glycerophospholipid biosynthetic process | 102/7305 | 211/18723 | 3.50e-03 | 1.48e-02 | 102 |
GO:00066445 | Oral cavity | OSCC | phospholipid metabolic process | 175/7305 | 383/18723 | 4.21e-03 | 1.71e-02 | 175 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTDSS1 | SNV | Missense_Mutation | c.1391N>T | p.Ser464Leu | p.S464L | P48651 | protein_coding | tolerated(0.1) | benign(0.007) | TCGA-DD-A11A-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PTDSS1 | deletion | Frame_Shift_Del | novel | c.1114delN | p.Gly372AspfsTer31 | p.G372Dfs*31 | P48651 | protein_coding | TCGA-DD-AACW-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
PTDSS1 | SNV | Missense_Mutation | c.973N>A | p.Leu325Ile | p.L325I | P48651 | protein_coding | tolerated(0.59) | benign(0.401) | TCGA-44-8119-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PTDSS1 | SNV | Missense_Mutation | c.523N>T | p.Gly175Cys | p.G175C | P48651 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR | |
PTDSS1 | SNV | Missense_Mutation | c.743C>T | p.Ala248Val | p.A248V | P48651 | protein_coding | tolerated(0.2) | benign(0.042) | TCGA-55-8087-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PTDSS1 | SNV | Missense_Mutation | c.740N>T | p.Trp247Leu | p.W247L | P48651 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-55-8302-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PTDSS1 | SNV | Missense_Mutation | c.602N>A | p.Leu201His | p.L201H | P48651 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-75-7027-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | PD | |
PTDSS1 | SNV | Missense_Mutation | c.674N>A | p.Cys225Tyr | p.C225Y | P48651 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
PTDSS1 | SNV | Missense_Mutation | c.677N>G | p.Asn226Ser | p.N226S | P48651 | protein_coding | deleterious(0.02) | possibly_damaging(0.687) | TCGA-80-5607-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
PTDSS1 | SNV | Missense_Mutation | c.889T>C | p.Trp297Arg | p.W297R | P48651 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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