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Gene: PRR19 |
Gene summary for PRR19 |
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Gene information | Species | Human | Gene symbol | PRR19 | Gene ID | 284338 |
Gene name | proline rich 19 | |
Gene Alias | PRR19 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A6NJB7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284338 | PRR19 | S014 | Human | Liver | HCC | 2.83e-27 | 7.43e-01 | 0.2254 |
284338 | PRR19 | S015 | Human | Liver | HCC | 6.83e-29 | 1.01e+00 | 0.2375 |
284338 | PRR19 | S016 | Human | Liver | HCC | 1.14e-37 | 9.66e-01 | 0.2243 |
284338 | PRR19 | S029 | Human | Liver | HCC | 1.62e-03 | 1.42e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRR19 | SNV | Missense_Mutation | novel | c.235N>A | p.His79Asn | p.H79N | A6NJB7 | protein_coding | deleterious(0.04) | benign(0.015) | TCGA-43-2576-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
PRR19 | SNV | Missense_Mutation | novel | c.871C>G | p.Leu291Val | p.L291V | A6NJB7 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.684) | TCGA-77-A5GH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRR19 | SNV | Missense_Mutation | novel | c.43G>C | p.Glu15Gln | p.E15Q | A6NJB7 | protein_coding | tolerated(0.21) | benign(0.096) | TCGA-92-8065-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRR19 | deletion | Frame_Shift_Del | novel | c.289delN | p.Pro97GlnfsTer59 | p.P97Qfs*59 | A6NJB7 | protein_coding | TCGA-22-1012-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PRR19 | SNV | Missense_Mutation | c.352N>G | p.Pro118Ala | p.P118A | A6NJB7 | protein_coding | tolerated(0.75) | benign(0.022) | TCGA-CV-A6JD-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRR19 | SNV | Missense_Mutation | novel | c.214G>A | p.Glu72Lys | p.E72K | A6NJB7 | protein_coding | tolerated(0.07) | benign(0.027) | TCGA-UF-A7J9-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRR19 | SNV | Missense_Mutation | novel | c.85N>T | p.Arg29Cys | p.R29C | A6NJB7 | protein_coding | deleterious(0) | benign(0.067) | TCGA-HC-A9TE-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | eligard | SD |
PRR19 | SNV | Missense_Mutation | novel | c.85N>T | p.Arg29Cys | p.R29C | A6NJB7 | protein_coding | deleterious(0) | benign(0.067) | TCGA-3M-AB46-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | fluorouracil | CR |
PRR19 | SNV | Missense_Mutation | novel | c.1066N>C | p.Tyr356His | p.Y356H | A6NJB7 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PRR19 | SNV | Missense_Mutation | rs368156714 | c.577N>T | p.Arg193Trp | p.R193W | A6NJB7 | protein_coding | deleterious(0.03) | benign(0.005) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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