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Gene: PRPF31 |
Gene summary for PRPF31 |
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Gene information | Species | Human | Gene symbol | PRPF31 | Gene ID | 26121 |
Gene name | pre-mRNA processing factor 31 | |
Gene Alias | NY-BR-99 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0000244 | UniProtAcc | Q8WWY3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26121 | PRPF31 | LZE4T | Human | Esophagus | ESCC | 1.09e-09 | 3.21e-01 | 0.0811 |
26121 | PRPF31 | LZE5T | Human | Esophagus | ESCC | 1.15e-05 | 3.63e-01 | 0.0514 |
26121 | PRPF31 | LZE7T | Human | Esophagus | ESCC | 7.25e-16 | 9.24e-01 | 0.0667 |
26121 | PRPF31 | LZE8T | Human | Esophagus | ESCC | 2.55e-03 | 2.19e-01 | 0.067 |
26121 | PRPF31 | LZE20T | Human | Esophagus | ESCC | 1.01e-03 | 1.74e-01 | 0.0662 |
26121 | PRPF31 | LZE22D1 | Human | Esophagus | HGIN | 2.59e-04 | 9.16e-02 | 0.0595 |
26121 | PRPF31 | LZE24T | Human | Esophagus | ESCC | 7.70e-23 | 4.76e-01 | 0.0596 |
26121 | PRPF31 | LZE21T | Human | Esophagus | ESCC | 6.44e-06 | 2.38e-01 | 0.0655 |
26121 | PRPF31 | LZE6T | Human | Esophagus | ESCC | 4.62e-07 | 4.75e-01 | 0.0845 |
26121 | PRPF31 | P1T-E | Human | Esophagus | ESCC | 1.70e-12 | 5.96e-01 | 0.0875 |
26121 | PRPF31 | P2T-E | Human | Esophagus | ESCC | 1.35e-23 | 4.64e-01 | 0.1177 |
26121 | PRPF31 | P4T-E | Human | Esophagus | ESCC | 5.03e-31 | 6.88e-01 | 0.1323 |
26121 | PRPF31 | P5T-E | Human | Esophagus | ESCC | 3.16e-19 | 2.94e-01 | 0.1327 |
26121 | PRPF31 | P8T-E | Human | Esophagus | ESCC | 4.49e-57 | 1.19e+00 | 0.0889 |
26121 | PRPF31 | P9T-E | Human | Esophagus | ESCC | 1.83e-16 | 3.02e-01 | 0.1131 |
26121 | PRPF31 | P10T-E | Human | Esophagus | ESCC | 9.55e-55 | 9.45e-01 | 0.116 |
26121 | PRPF31 | P11T-E | Human | Esophagus | ESCC | 1.14e-16 | 7.28e-01 | 0.1426 |
26121 | PRPF31 | P12T-E | Human | Esophagus | ESCC | 2.62e-35 | 6.86e-01 | 0.1122 |
26121 | PRPF31 | P15T-E | Human | Esophagus | ESCC | 6.42e-43 | 8.98e-01 | 0.1149 |
26121 | PRPF31 | P16T-E | Human | Esophagus | ESCC | 4.49e-24 | 4.15e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:000037520 | Esophagus | HGIN | RNA splicing, via transesterification reactions | 115/2587 | 324/18723 | 3.16e-23 | 3.80e-20 | 115 |
GO:000037720 | Esophagus | HGIN | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:000039820 | Esophagus | HGIN | mRNA splicing, via spliceosome | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:007182627 | Esophagus | HGIN | ribonucleoprotein complex subunit organization | 84/2587 | 227/18723 | 1.34e-18 | 5.37e-16 | 84 |
GO:002261827 | Esophagus | HGIN | ribonucleoprotein complex assembly | 82/2587 | 220/18723 | 2.07e-18 | 7.36e-16 | 82 |
GO:00711665 | Esophagus | HGIN | ribonucleoprotein complex localization | 23/2587 | 77/18723 | 2.00e-04 | 3.72e-03 | 23 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0071826111 | Esophagus | ESCC | ribonucleoprotein complex subunit organization | 166/8552 | 227/18723 | 2.94e-17 | 2.42e-15 | 166 |
GO:0022618111 | Esophagus | ESCC | ribonucleoprotein complex assembly | 159/8552 | 220/18723 | 8.19e-16 | 5.71e-14 | 159 |
GO:007116612 | Esophagus | ESCC | ribonucleoprotein complex localization | 66/8552 | 77/18723 | 2.94e-13 | 1.38e-11 | 66 |
GO:00003875 | Esophagus | ESCC | spliceosomal snRNP assembly | 32/8552 | 50/18723 | 6.90e-03 | 2.52e-02 | 32 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:000037512 | Liver | Cirrhotic | RNA splicing, via transesterification reactions | 175/4634 | 324/18723 | 5.95e-30 | 7.47e-27 | 175 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304016 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304017 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304026 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
hsa0304036 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRPF31 | SNV | Missense_Mutation | novel | c.456N>A | p.Asn152Lys | p.N152K | Q8WWY3 | protein_coding | tolerated(0.2) | benign(0.163) | TCGA-RC-A6M6-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRPF31 | SNV | Missense_Mutation | c.174N>C | p.Lys58Asn | p.K58N | Q8WWY3 | protein_coding | tolerated(0.12) | benign(0.085) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
PRPF31 | SNV | Missense_Mutation | novel | c.109G>A | p.Glu37Lys | p.E37K | Q8WWY3 | protein_coding | tolerated(0.34) | possibly_damaging(0.899) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PRPF31 | SNV | Missense_Mutation | novel | c.793N>C | p.Thr265Pro | p.T265P | Q8WWY3 | protein_coding | tolerated(0.05) | benign(0.089) | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRPF31 | SNV | Missense_Mutation | novel | c.211N>G | p.Ile71Val | p.I71V | Q8WWY3 | protein_coding | tolerated(0.37) | benign(0) | TCGA-60-2703-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PRPF31 | SNV | Missense_Mutation | novel | c.1375N>T | p.Gly459Cys | p.G459C | Q8WWY3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-60-2703-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PRPF31 | SNV | Missense_Mutation | novel | c.587N>T | p.Glu196Val | p.E196V | Q8WWY3 | protein_coding | deleterious(0.03) | benign(0.296) | TCGA-85-A4JB-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | CR |
PRPF31 | SNV | Missense_Mutation | novel | c.28G>A | p.Asp10Asn | p.D10N | Q8WWY3 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-98-A53I-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | navelbine | SD |
PRPF31 | SNV | Missense_Mutation | novel | c.200N>C | p.Ile67Thr | p.I67T | Q8WWY3 | protein_coding | deleterious(0) | probably_damaging(0.919) | TCGA-CN-4730-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PRPF31 | SNV | Missense_Mutation | rs867019753 | c.1474G>A | p.Glu492Lys | p.E492K | Q8WWY3 | protein_coding | tolerated_low_confidence(0.19) | benign(0) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
26121 | PRPF31 | NA | metformin | METFORMIN | 29650774 |
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