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Gene: PRICKLE3 |
Gene summary for PRICKLE3 |
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Gene information | Species | Human | Gene symbol | PRICKLE3 | Gene ID | 4007 |
Gene name | prickle planar cell polarity protein 3 | |
Gene Alias | LMO6 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | B7Z5U0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4007 | PRICKLE3 | LZE4T | Human | Esophagus | ESCC | 5.68e-07 | 2.59e-01 | 0.0811 |
4007 | PRICKLE3 | LZE7T | Human | Esophagus | ESCC | 6.13e-07 | 2.64e-01 | 0.0667 |
4007 | PRICKLE3 | LZE8T | Human | Esophagus | ESCC | 4.02e-05 | 1.76e-01 | 0.067 |
4007 | PRICKLE3 | LZE20T | Human | Esophagus | ESCC | 3.16e-03 | 1.51e-01 | 0.0662 |
4007 | PRICKLE3 | LZE21D1 | Human | Esophagus | HGIN | 4.41e-04 | 3.28e-01 | 0.0632 |
4007 | PRICKLE3 | LZE22D1 | Human | Esophagus | HGIN | 5.14e-03 | 1.98e-01 | 0.0595 |
4007 | PRICKLE3 | LZE22T | Human | Esophagus | ESCC | 1.57e-03 | 3.33e-01 | 0.068 |
4007 | PRICKLE3 | LZE24T | Human | Esophagus | ESCC | 7.85e-14 | 3.02e-01 | 0.0596 |
4007 | PRICKLE3 | LZE21T | Human | Esophagus | ESCC | 1.57e-07 | 3.19e-01 | 0.0655 |
4007 | PRICKLE3 | P1T-E | Human | Esophagus | ESCC | 5.20e-08 | 3.28e-01 | 0.0875 |
4007 | PRICKLE3 | P2T-E | Human | Esophagus | ESCC | 2.39e-24 | 4.17e-01 | 0.1177 |
4007 | PRICKLE3 | P4T-E | Human | Esophagus | ESCC | 1.17e-15 | 3.55e-01 | 0.1323 |
4007 | PRICKLE3 | P5T-E | Human | Esophagus | ESCC | 2.20e-17 | 3.68e-01 | 0.1327 |
4007 | PRICKLE3 | P8T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.61e-01 | 0.0889 |
4007 | PRICKLE3 | P9T-E | Human | Esophagus | ESCC | 1.09e-13 | 3.30e-01 | 0.1131 |
4007 | PRICKLE3 | P10T-E | Human | Esophagus | ESCC | 4.30e-10 | 1.78e-01 | 0.116 |
4007 | PRICKLE3 | P11T-E | Human | Esophagus | ESCC | 2.06e-07 | 3.33e-01 | 0.1426 |
4007 | PRICKLE3 | P12T-E | Human | Esophagus | ESCC | 9.53e-09 | 2.00e-01 | 0.1122 |
4007 | PRICKLE3 | P15T-E | Human | Esophagus | ESCC | 5.63e-18 | 3.79e-01 | 0.1149 |
4007 | PRICKLE3 | P16T-E | Human | Esophagus | ESCC | 1.13e-16 | 3.37e-01 | 0.1153 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRICKLE3 | SNV | Missense_Mutation | novel | c.733N>A | p.Glu245Lys | p.E245K | O43900 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRICKLE3 | SNV | Missense_Mutation | rs181835917 | c.473N>A | p.Arg158Gln | p.R158Q | O43900 | protein_coding | tolerated(0.09) | benign(0.274) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRICKLE3 | SNV | Missense_Mutation | rs186856741 | c.887N>A | p.Arg296His | p.R296H | O43900 | protein_coding | tolerated(0.11) | benign(0.409) | TCGA-AP-A1E1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRICKLE3 | SNV | Missense_Mutation | rs782611814 | c.742N>T | p.Arg248Cys | p.R248C | O43900 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AX-A06H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
PRICKLE3 | SNV | Missense_Mutation | novel | c.1789N>T | p.Arg597Trp | p.R597W | O43900 | protein_coding | deleterious_low_confidence(0.01) | benign(0.171) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRICKLE3 | SNV | Missense_Mutation | rs144390456 | c.1663N>A | p.Glu555Lys | p.E555K | O43900 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.522) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
PRICKLE3 | SNV | Missense_Mutation | rs782047819 | c.1143C>G | p.Ser381Arg | p.S381R | O43900 | protein_coding | deleterious(0.04) | benign(0.018) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PRICKLE3 | SNV | Missense_Mutation | c.1675N>A | p.Asp559Asn | p.D559N | O43900 | protein_coding | deleterious_low_confidence(0) | benign(0.166) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
PRICKLE3 | SNV | Missense_Mutation | rs782653464 | c.1700N>A | p.Arg567His | p.R567H | O43900 | protein_coding | tolerated_low_confidence(0.08) | possibly_damaging(0.747) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRICKLE3 | SNV | Missense_Mutation | c.595N>A | p.Ala199Thr | p.A199T | O43900 | protein_coding | deleterious(0.01) | probably_damaging(0.957) | TCGA-B5-A11R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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