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Gene: PRDM1 |
Gene summary for PRDM1 |
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Gene information | Species | Human | Gene symbol | PRDM1 | Gene ID | 639 |
Gene name | PR/SET domain 1 | |
Gene Alias | BLIMP1 | |
Cytomap | 6q21 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O75626 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
639 | PRDM1 | LZE4T | Human | Esophagus | ESCC | 1.55e-06 | 2.66e-01 | 0.0811 |
639 | PRDM1 | LZE7T | Human | Esophagus | ESCC | 5.67e-11 | 6.73e-01 | 0.0667 |
639 | PRDM1 | LZE6T | Human | Esophagus | ESCC | 3.26e-08 | 6.11e-01 | 0.0845 |
639 | PRDM1 | P1T-E | Human | Esophagus | ESCC | 3.87e-04 | 5.77e-01 | 0.0875 |
639 | PRDM1 | P4T-E | Human | Esophagus | ESCC | 9.51e-03 | 1.12e-01 | 0.1323 |
639 | PRDM1 | P5T-E | Human | Esophagus | ESCC | 2.41e-04 | 1.40e-01 | 0.1327 |
639 | PRDM1 | P8T-E | Human | Esophagus | ESCC | 1.11e-03 | 2.60e-01 | 0.0889 |
639 | PRDM1 | P10T-E | Human | Esophagus | ESCC | 2.02e-12 | 1.68e-01 | 0.116 |
639 | PRDM1 | P15T-E | Human | Esophagus | ESCC | 7.15e-08 | 3.15e-01 | 0.1149 |
639 | PRDM1 | P22T-E | Human | Esophagus | ESCC | 1.37e-02 | 7.27e-02 | 0.1236 |
639 | PRDM1 | P23T-E | Human | Esophagus | ESCC | 1.42e-19 | 6.32e-01 | 0.108 |
639 | PRDM1 | P26T-E | Human | Esophagus | ESCC | 3.38e-18 | 4.29e-01 | 0.1276 |
639 | PRDM1 | P28T-E | Human | Esophagus | ESCC | 1.12e-12 | 3.76e-01 | 0.1149 |
639 | PRDM1 | P30T-E | Human | Esophagus | ESCC | 2.11e-06 | 3.76e-01 | 0.137 |
639 | PRDM1 | P31T-E | Human | Esophagus | ESCC | 1.02e-02 | 9.17e-02 | 0.1251 |
639 | PRDM1 | P32T-E | Human | Esophagus | ESCC | 9.87e-04 | 1.82e-01 | 0.1666 |
639 | PRDM1 | P36T-E | Human | Esophagus | ESCC | 5.96e-08 | 5.08e-01 | 0.1187 |
639 | PRDM1 | P37T-E | Human | Esophagus | ESCC | 8.76e-10 | 3.44e-01 | 0.1371 |
639 | PRDM1 | P39T-E | Human | Esophagus | ESCC | 2.93e-13 | 3.71e-01 | 0.0894 |
639 | PRDM1 | P42T-E | Human | Esophagus | ESCC | 1.12e-09 | 3.99e-01 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:0001890110 | Esophagus | ESCC | placenta development | 98/8552 | 144/18723 | 4.46e-08 | 8.11e-07 | 98 |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:000206420 | Esophagus | ESCC | epithelial cell development | 136/8552 | 220/18723 | 9.50e-07 | 1.21e-05 | 136 |
GO:00097919 | Esophagus | ESCC | post-embryonic development | 56/8552 | 80/18723 | 9.08e-06 | 8.71e-05 | 56 |
GO:000189219 | Esophagus | ESCC | embryonic placenta development | 57/8552 | 82/18723 | 1.06e-05 | 1.01e-04 | 57 |
GO:00018937 | Esophagus | ESCC | maternal placenta development | 28/8552 | 35/18723 | 3.40e-05 | 2.78e-04 | 28 |
GO:1903706110 | Esophagus | ESCC | regulation of hemopoiesis | 201/8552 | 367/18723 | 2.60e-04 | 1.58e-03 | 201 |
GO:00485687 | Esophagus | ESCC | embryonic organ development | 228/8552 | 427/18723 | 7.28e-04 | 3.79e-03 | 228 |
GO:004211018 | Esophagus | ESCC | T cell activation | 256/8552 | 487/18723 | 1.18e-03 | 5.87e-03 | 256 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
GO:190210510 | Esophagus | ESCC | regulation of leukocyte differentiation | 152/8552 | 279/18723 | 1.82e-03 | 8.35e-03 | 152 |
GO:00601357 | Esophagus | ESCC | maternal process involved in female pregnancy | 40/8552 | 62/18723 | 2.14e-03 | 9.54e-03 | 40 |
GO:00605763 | Esophagus | ESCC | intestinal epithelial cell development | 12/8552 | 14/18723 | 2.51e-03 | 1.08e-02 | 12 |
GO:0002066 | Esophagus | ESCC | columnar/cuboidal epithelial cell development | 29/8552 | 44/18723 | 5.41e-03 | 2.02e-02 | 29 |
GO:00607065 | Esophagus | ESCC | cell differentiation involved in embryonic placenta development | 18/8552 | 25/18723 | 7.04e-03 | 2.56e-02 | 18 |
GO:00016559 | Esophagus | ESCC | urogenital system development | 177/8552 | 338/18723 | 7.51e-03 | 2.69e-02 | 177 |
GO:00302176 | Esophagus | ESCC | T cell differentiation | 137/8552 | 257/18723 | 8.09e-03 | 2.87e-02 | 137 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRDM1 | SNV | Missense_Mutation | novel | c.2193G>T | p.Glu731Asp | p.E731D | O75626 | protein_coding | tolerated(0.21) | possibly_damaging(0.603) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PRDM1 | insertion | Nonsense_Mutation | novel | c.319_320insACTAACAATGATAAAAT | p.Ile107AsnfsTer2 | p.I107Nfs*2 | O75626 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PRDM1 | deletion | Frame_Shift_Del | c.47delN | p.Lys18SerfsTer7 | p.K18Sfs*7 | O75626 | protein_coding | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
PRDM1 | SNV | Missense_Mutation | novel | c.890N>C | p.Val297Ala | p.V297A | O75626 | protein_coding | tolerated(0.44) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PRDM1 | SNV | Missense_Mutation | c.1451C>A | p.Pro484His | p.P484H | O75626 | protein_coding | tolerated(0.06) | possibly_damaging(0.855) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRDM1 | SNV | Missense_Mutation | c.1076C>T | p.Thr359Met | p.T359M | O75626 | protein_coding | tolerated(0.1) | benign(0.432) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRDM1 | SNV | Missense_Mutation | novel | c.380N>A | p.Pro127His | p.P127H | O75626 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRDM1 | SNV | Missense_Mutation | c.236C>T | p.Ala79Val | p.A79V | O75626 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
PRDM1 | SNV | Missense_Mutation | c.2234N>C | p.Val745Ala | p.V745A | O75626 | protein_coding | tolerated(0.56) | benign(0) | TCGA-AP-A05J-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
PRDM1 | SNV | Missense_Mutation | novel | c.493N>A | p.Ala165Thr | p.A165T | O75626 | protein_coding | deleterious(0) | benign(0.096) | TCGA-AP-A0LS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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