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Gene: PRCP |
Gene summary for PRCP |
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Gene information | Species | Human | Gene symbol | PRCP | Gene ID | 5547 |
Gene name | prolylcarboxypeptidase | |
Gene Alias | HUMPCP | |
Cytomap | 11q14.1 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | B7Z7Q6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5547 | PRCP | LZE4T | Human | Esophagus | ESCC | 5.62e-05 | 1.20e-01 | 0.0811 |
5547 | PRCP | LZE8T | Human | Esophagus | ESCC | 7.35e-06 | 3.10e-01 | 0.067 |
5547 | PRCP | LZE20T | Human | Esophagus | ESCC | 5.66e-04 | 2.76e-01 | 0.0662 |
5547 | PRCP | LZE24T | Human | Esophagus | ESCC | 2.62e-22 | 7.49e-01 | 0.0596 |
5547 | PRCP | P2T-E | Human | Esophagus | ESCC | 6.15e-28 | 4.70e-01 | 0.1177 |
5547 | PRCP | P4T-E | Human | Esophagus | ESCC | 2.26e-50 | 1.34e+00 | 0.1323 |
5547 | PRCP | P8T-E | Human | Esophagus | ESCC | 3.94e-11 | 3.03e-01 | 0.0889 |
5547 | PRCP | P9T-E | Human | Esophagus | ESCC | 1.42e-15 | 6.30e-01 | 0.1131 |
5547 | PRCP | P10T-E | Human | Esophagus | ESCC | 4.89e-30 | 5.51e-01 | 0.116 |
5547 | PRCP | P11T-E | Human | Esophagus | ESCC | 6.26e-26 | 1.05e+00 | 0.1426 |
5547 | PRCP | P12T-E | Human | Esophagus | ESCC | 3.77e-58 | 1.27e+00 | 0.1122 |
5547 | PRCP | P15T-E | Human | Esophagus | ESCC | 2.84e-13 | 2.88e-01 | 0.1149 |
5547 | PRCP | P16T-E | Human | Esophagus | ESCC | 5.68e-54 | 1.27e+00 | 0.1153 |
5547 | PRCP | P17T-E | Human | Esophagus | ESCC | 1.26e-08 | 5.34e-01 | 0.1278 |
5547 | PRCP | P19T-E | Human | Esophagus | ESCC | 9.14e-06 | 7.08e-01 | 0.1662 |
5547 | PRCP | P20T-E | Human | Esophagus | ESCC | 4.16e-14 | 4.57e-01 | 0.1124 |
5547 | PRCP | P21T-E | Human | Esophagus | ESCC | 4.15e-44 | 6.99e-01 | 0.1617 |
5547 | PRCP | P22T-E | Human | Esophagus | ESCC | 6.28e-29 | 3.89e-01 | 0.1236 |
5547 | PRCP | P23T-E | Human | Esophagus | ESCC | 5.64e-30 | 9.53e-01 | 0.108 |
5547 | PRCP | P24T-E | Human | Esophagus | ESCC | 4.61e-06 | 3.32e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030522110 | Esophagus | ESCC | intracellular receptor signaling pathway | 170/8552 | 265/18723 | 8.58e-10 | 2.09e-08 | 170 |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:200037718 | Esophagus | ESCC | regulation of reactive oxygen species metabolic process | 100/8552 | 157/18723 | 3.87e-06 | 4.17e-05 | 100 |
GO:007259318 | Esophagus | ESCC | reactive oxygen species metabolic process | 137/8552 | 239/18723 | 1.82e-04 | 1.16e-03 | 137 |
GO:000166720 | Esophagus | ESCC | ameboidal-type cell migration | 250/8552 | 475/18723 | 1.22e-03 | 5.97e-03 | 250 |
GO:000975516 | Esophagus | ESCC | hormone-mediated signaling pathway | 106/8552 | 190/18723 | 3.13e-03 | 1.30e-02 | 106 |
GO:001063120 | Esophagus | ESCC | epithelial cell migration | 187/8552 | 357/18723 | 6.05e-03 | 2.23e-02 | 187 |
GO:009013220 | Esophagus | ESCC | epithelium migration | 188/8552 | 360/18723 | 6.96e-03 | 2.54e-02 | 188 |
GO:009013020 | Esophagus | ESCC | tissue migration | 190/8552 | 365/18723 | 7.91e-03 | 2.82e-02 | 190 |
GO:004206012 | Liver | Cirrhotic | wound healing | 155/4634 | 422/18723 | 2.12e-08 | 7.56e-07 | 155 |
GO:003052212 | Liver | Cirrhotic | intracellular receptor signaling pathway | 105/4634 | 265/18723 | 5.44e-08 | 1.69e-06 | 105 |
GO:200037712 | Liver | Cirrhotic | regulation of reactive oxygen species metabolic process | 67/4634 | 157/18723 | 6.07e-07 | 1.32e-05 | 67 |
GO:00725937 | Liver | Cirrhotic | reactive oxygen species metabolic process | 92/4634 | 239/18723 | 1.57e-06 | 3.03e-05 | 92 |
GO:000975511 | Liver | Cirrhotic | hormone-mediated signaling pathway | 71/4634 | 190/18723 | 7.09e-05 | 7.98e-04 | 71 |
GO:00723761 | Liver | Cirrhotic | protein activation cascade | 9/4634 | 12/18723 | 3.59e-04 | 3.03e-03 | 9 |
GO:004259312 | Liver | Cirrhotic | glucose homeostasis | 86/4634 | 258/18723 | 1.12e-03 | 7.73e-03 | 86 |
GO:003350012 | Liver | Cirrhotic | carbohydrate homeostasis | 86/4634 | 259/18723 | 1.28e-03 | 8.61e-03 | 86 |
GO:000166712 | Liver | Cirrhotic | ameboidal-type cell migration | 145/4634 | 475/18723 | 2.23e-03 | 1.36e-02 | 145 |
GO:00106327 | Liver | Cirrhotic | regulation of epithelial cell migration | 93/4634 | 292/18723 | 3.46e-03 | 1.92e-02 | 93 |
GO:00106317 | Liver | Cirrhotic | epithelial cell migration | 110/4634 | 357/18723 | 5.14e-03 | 2.65e-02 | 110 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRCP | SNV | Missense_Mutation | rs765431937 | c.1354N>A | p.Pro452Thr | p.P452T | P42785 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DD-AAEB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PRCP | SNV | Missense_Mutation | novel | c.346N>T | p.Asp116Tyr | p.D116Y | P42785 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-05-4424-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | erlotinib | SD |
PRCP | SNV | Missense_Mutation | c.629N>T | p.Arg210Met | p.R210M | P42785 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
PRCP | SNV | Missense_Mutation | novel | c.1200G>A | p.Met400Ile | p.M400I | P42785 | protein_coding | tolerated(0.05) | possibly_damaging(0.759) | TCGA-55-7576-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | alimta | CR |
PRCP | SNV | Missense_Mutation | c.664G>T | p.Ala222Ser | p.A222S | P42785 | protein_coding | deleterious(0.03) | probably_damaging(0.951) | TCGA-55-8514-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRCP | SNV | Missense_Mutation | c.1015G>T | p.Val339Leu | p.V339L | P42785 | protein_coding | tolerated(0.8) | benign(0.006) | TCGA-62-A46S-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | tarceva | PD | |
PRCP | SNV | Missense_Mutation | c.1448A>G | p.Lys483Arg | p.K483R | P42785 | protein_coding | tolerated(0.19) | benign(0.012) | TCGA-78-7154-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PRCP | SNV | Missense_Mutation | rs745794657 | c.384N>T | p.Trp128Cys | p.W128C | P42785 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
PRCP | SNV | Missense_Mutation | c.1271G>T | p.Arg424Met | p.R424M | P42785 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-22-0944-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PRCP | SNV | Missense_Mutation | c.1399N>C | p.Val467Leu | p.V467L | P42785 | protein_coding | tolerated(0.14) | benign(0.049) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5547 | PRCP | ENZYME, DRUGGABLE GENOME, PROTEASE | Piperidinyl pyrazole derivative 3 | |||
5547 | PRCP | ENZYME, DRUGGABLE GENOME, PROTEASE | benazepril | BENAZEPRIL | 20079160 | |
5547 | PRCP | ENZYME, DRUGGABLE GENOME, PROTEASE | Piperidinyl triazole derivative 3 | |||
5547 | PRCP | ENZYME, DRUGGABLE GENOME, PROTEASE | Benzodihydroisofuran derivative 2 | |||
5547 | PRCP | ENZYME, DRUGGABLE GENOME, PROTEASE | Cyclohexane carboxamide derivative 3 | |||
5547 | PRCP | ENZYME, DRUGGABLE GENOME, PROTEASE | Benzodihydroisofuran derivative 3 | |||
5547 | PRCP | ENZYME, DRUGGABLE GENOME, PROTEASE | Benzodihydroisofuran derivative 4 | |||
5547 | PRCP | ENZYME, DRUGGABLE GENOME, PROTEASE | Benzodihydroisofuran derivative 1 | |||
5547 | PRCP | ENZYME, DRUGGABLE GENOME, PROTEASE | Imidazole derivative 8 | |||
5547 | PRCP | ENZYME, DRUGGABLE GENOME, PROTEASE | Proline amide derivative 1 |
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