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Gene: PPP2R2D |
Gene summary for PPP2R2D |
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Gene information | Species | Human | Gene symbol | PPP2R2D | Gene ID | 55844 |
Gene name | protein phosphatase 2 regulatory subunit Bdelta | |
Gene Alias | B55D | |
Cytomap | 10q26.3 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q66LE6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55844 | PPP2R2D | CA_HPV_1 | Human | Cervix | CC | 4.99e-02 | -9.57e-02 | 0.0264 |
55844 | PPP2R2D | CCI_2 | Human | Cervix | CC | 2.74e-02 | 6.15e-01 | 0.5249 |
55844 | PPP2R2D | CCI_3 | Human | Cervix | CC | 1.08e-04 | 5.20e-01 | 0.516 |
55844 | PPP2R2D | LZE8T | Human | Esophagus | ESCC | 4.17e-02 | -8.79e-03 | 0.067 |
55844 | PPP2R2D | LZE24T | Human | Esophagus | ESCC | 2.20e-06 | 4.77e-02 | 0.0596 |
55844 | PPP2R2D | P1T-E | Human | Esophagus | ESCC | 2.55e-04 | 2.18e-01 | 0.0875 |
55844 | PPP2R2D | P2T-E | Human | Esophagus | ESCC | 2.12e-17 | 2.95e-01 | 0.1177 |
55844 | PPP2R2D | P4T-E | Human | Esophagus | ESCC | 3.18e-19 | 3.46e-01 | 0.1323 |
55844 | PPP2R2D | P5T-E | Human | Esophagus | ESCC | 2.64e-16 | 2.84e-01 | 0.1327 |
55844 | PPP2R2D | P8T-E | Human | Esophagus | ESCC | 1.34e-15 | 1.61e-01 | 0.0889 |
55844 | PPP2R2D | P9T-E | Human | Esophagus | ESCC | 2.68e-06 | 5.88e-02 | 0.1131 |
55844 | PPP2R2D | P10T-E | Human | Esophagus | ESCC | 1.31e-03 | 4.51e-03 | 0.116 |
55844 | PPP2R2D | P11T-E | Human | Esophagus | ESCC | 1.16e-06 | 1.36e-01 | 0.1426 |
55844 | PPP2R2D | P12T-E | Human | Esophagus | ESCC | 2.72e-12 | 1.92e-01 | 0.1122 |
55844 | PPP2R2D | P15T-E | Human | Esophagus | ESCC | 6.22e-13 | 2.41e-01 | 0.1149 |
55844 | PPP2R2D | P16T-E | Human | Esophagus | ESCC | 3.04e-15 | 6.94e-02 | 0.1153 |
55844 | PPP2R2D | P17T-E | Human | Esophagus | ESCC | 1.98e-02 | 2.74e-02 | 0.1278 |
55844 | PPP2R2D | P20T-E | Human | Esophagus | ESCC | 2.43e-08 | 9.03e-02 | 0.1124 |
55844 | PPP2R2D | P21T-E | Human | Esophagus | ESCC | 8.09e-08 | 1.12e-01 | 0.1617 |
55844 | PPP2R2D | P22T-E | Human | Esophagus | ESCC | 8.31e-10 | 1.45e-02 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00447725 | Cervix | CC | mitotic cell cycle phase transition | 89/2311 | 424/18723 | 2.70e-07 | 1.12e-05 | 89 |
GO:00064708 | Cervix | CC | protein dephosphorylation | 60/2311 | 281/18723 | 1.33e-05 | 2.68e-04 | 60 |
GO:00163117 | Cervix | CC | dephosphorylation | 73/2311 | 417/18723 | 1.23e-03 | 9.87e-03 | 73 |
GO:01400143 | Cervix | CC | mitotic nuclear division | 50/2311 | 287/18723 | 7.27e-03 | 3.91e-02 | 50 |
GO:00482851 | Cervix | CC | organelle fission | 78/2311 | 488/18723 | 9.70e-03 | 4.79e-02 | 78 |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:00702624 | Esophagus | ESCC | peptidyl-serine dephosphorylation | 16/8552 | 19/18723 | 6.45e-04 | 3.43e-03 | 16 |
GO:01400145 | Oral cavity | OSCC | mitotic nuclear division | 191/7305 | 287/18723 | 1.99e-21 | 3.70e-19 | 191 |
GO:00447728 | Oral cavity | OSCC | mitotic cell cycle phase transition | 255/7305 | 424/18723 | 5.29e-19 | 6.98e-17 | 255 |
GO:00482852 | Oral cavity | OSCC | organelle fission | 265/7305 | 488/18723 | 3.22e-12 | 1.27e-10 | 265 |
GO:00002801 | Oral cavity | OSCC | nuclear division | 237/7305 | 439/18723 | 9.62e-11 | 2.90e-09 | 237 |
GO:000647015 | Oral cavity | OSCC | protein dephosphorylation | 162/7305 | 281/18723 | 1.56e-10 | 4.56e-09 | 162 |
GO:00163119 | Oral cavity | OSCC | dephosphorylation | 220/7305 | 417/18723 | 6.33e-09 | 1.34e-07 | 220 |
GO:00702623 | Oral cavity | OSCC | peptidyl-serine dephosphorylation | 16/7305 | 19/18723 | 7.05e-05 | 5.60e-04 | 16 |
GO:0010458 | Oral cavity | OSCC | exit from mitosis | 21/7305 | 29/18723 | 2.73e-04 | 1.73e-03 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0453020 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0407110 | Cervix | CC | Sphingolipid signaling pathway | 35/1267 | 121/8465 | 5.70e-05 | 3.93e-04 | 2.32e-04 | 35 |
hsa051657 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa04530110 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0407113 | Cervix | CC | Sphingolipid signaling pathway | 35/1267 | 121/8465 | 5.70e-05 | 3.93e-04 | 2.32e-04 | 35 |
hsa0516512 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0301524 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa051609 | Esophagus | ESCC | Hepatitis C | 107/4205 | 157/8465 | 1.75e-06 | 1.08e-05 | 5.55e-06 | 107 |
hsa0407116 | Esophagus | ESCC | Sphingolipid signaling pathway | 85/4205 | 121/8465 | 3.04e-06 | 1.73e-05 | 8.84e-06 | 85 |
hsa0415210 | Esophagus | ESCC | AMPK signaling pathway | 80/4205 | 121/8465 | 1.73e-04 | 6.67e-04 | 3.42e-04 | 80 |
hsa04530211 | Esophagus | ESCC | Tight junction | 105/4205 | 169/8465 | 6.73e-04 | 2.23e-03 | 1.14e-03 | 105 |
hsa051425 | Esophagus | ESCC | Chagas disease | 65/4205 | 102/8465 | 2.81e-03 | 7.59e-03 | 3.89e-03 | 65 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0516515 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0301534 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0516016 | Esophagus | ESCC | Hepatitis C | 107/4205 | 157/8465 | 1.75e-06 | 1.08e-05 | 5.55e-06 | 107 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP2R2D | SNV | Missense_Mutation | novel | c.1241T>A | p.Ile414Asn | p.I414N | Q66LE6 | protein_coding | deleterious(0.02) | possibly_damaging(0.877) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PPP2R2D | SNV | Missense_Mutation | rs782131911 | c.208C>T | p.Arg70Cys | p.R70C | Q66LE6 | protein_coding | tolerated(0.08) | benign(0) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPP2R2D | SNV | Missense_Mutation | c.527N>A | p.Arg176Gln | p.R176Q | Q66LE6 | protein_coding | deleterious(0.05) | probably_damaging(0.969) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
PPP2R2D | SNV | Missense_Mutation | rs142846802 | c.1076N>T | p.Ser359Leu | p.S359L | Q66LE6 | protein_coding | deleterious(0) | benign(0.094) | TCGA-EY-A2OO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
PPP2R2D | SNV | Missense_Mutation | novel | c.455N>T | p.Pro152Leu | p.P152L | Q66LE6 | protein_coding | tolerated(0.16) | benign(0.007) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPP2R2D | SNV | Missense_Mutation | novel | c.773N>A | p.Arg258His | p.R258H | Q66LE6 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-50-5931-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PPP2R2D | SNV | Missense_Mutation | rs782438973 | c.1201C>T | p.Arg401Trp | p.R401W | Q66LE6 | protein_coding | deleterious(0.02) | benign(0.266) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPP2R2D | SNV | Missense_Mutation | c.1295N>T | p.Pro432Leu | p.P432L | Q66LE6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PPP2R2D | SNV | Missense_Mutation | novel | c.1030N>A | p.Glu344Lys | p.E344K | Q66LE6 | protein_coding | deleterious(0.01) | probably_damaging(0.927) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PPP2R2D | deletion | Frame_Shift_Del | novel | c.527_528delNN | p.Arg176HisfsTer17 | p.R176Hfs*17 | Q66LE6 | protein_coding | TCGA-O2-A5IB-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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