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Gene: PPOX |
Gene summary for PPOX |
Gene summary. |
Gene information | Species | Human | Gene symbol | PPOX | Gene ID | 5498 |
Gene name | protoporphyrinogen oxidase | |
Gene Alias | PPO | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006725 | UniProtAcc | P50336 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5498 | PPOX | LZE4T | Human | Esophagus | ESCC | 1.49e-04 | 9.67e-02 | 0.0811 |
5498 | PPOX | LZE7T | Human | Esophagus | ESCC | 8.39e-08 | 3.06e-01 | 0.0667 |
5498 | PPOX | LZE20T | Human | Esophagus | ESCC | 3.28e-03 | 8.58e-02 | 0.0662 |
5498 | PPOX | LZE22T | Human | Esophagus | ESCC | 4.99e-02 | 2.07e-01 | 0.068 |
5498 | PPOX | LZE24T | Human | Esophagus | ESCC | 6.31e-13 | 2.40e-01 | 0.0596 |
5498 | PPOX | LZE6T | Human | Esophagus | ESCC | 3.59e-03 | 1.75e-01 | 0.0845 |
5498 | PPOX | P1T-E | Human | Esophagus | ESCC | 3.77e-06 | 3.20e-01 | 0.0875 |
5498 | PPOX | P2T-E | Human | Esophagus | ESCC | 2.35e-11 | 2.70e-01 | 0.1177 |
5498 | PPOX | P4T-E | Human | Esophagus | ESCC | 3.43e-13 | 2.22e-01 | 0.1323 |
5498 | PPOX | P5T-E | Human | Esophagus | ESCC | 6.66e-05 | 7.52e-02 | 0.1327 |
5498 | PPOX | P8T-E | Human | Esophagus | ESCC | 4.87e-07 | 1.30e-01 | 0.0889 |
5498 | PPOX | P9T-E | Human | Esophagus | ESCC | 1.04e-07 | 2.08e-01 | 0.1131 |
5498 | PPOX | P10T-E | Human | Esophagus | ESCC | 3.94e-17 | 2.67e-01 | 0.116 |
5498 | PPOX | P11T-E | Human | Esophagus | ESCC | 8.10e-09 | 3.31e-01 | 0.1426 |
5498 | PPOX | P12T-E | Human | Esophagus | ESCC | 4.83e-15 | 1.86e-01 | 0.1122 |
5498 | PPOX | P15T-E | Human | Esophagus | ESCC | 3.88e-09 | 1.30e-01 | 0.1149 |
5498 | PPOX | P16T-E | Human | Esophagus | ESCC | 3.16e-15 | 2.59e-01 | 0.1153 |
5498 | PPOX | P17T-E | Human | Esophagus | ESCC | 2.27e-03 | 1.77e-01 | 0.1278 |
5498 | PPOX | P19T-E | Human | Esophagus | ESCC | 1.23e-03 | 2.69e-01 | 0.1662 |
5498 | PPOX | P20T-E | Human | Esophagus | ESCC | 7.47e-14 | 2.74e-01 | 0.1124 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
GO:00067791 | Esophagus | ESCC | porphyrin-containing compound biosynthetic process | 23/8552 | 31/18723 | 1.20e-03 | 5.88e-03 | 23 |
GO:00330141 | Esophagus | ESCC | tetrapyrrole biosynthetic process | 23/8552 | 31/18723 | 1.20e-03 | 5.88e-03 | 23 |
GO:00461482 | Esophagus | ESCC | pigment biosynthetic process | 40/8552 | 62/18723 | 2.14e-03 | 9.54e-03 | 40 |
GO:00067832 | Esophagus | ESCC | heme biosynthetic process | 20/8552 | 27/18723 | 2.61e-03 | 1.11e-02 | 20 |
GO:00330132 | Esophagus | ESCC | tetrapyrrole metabolic process | 37/8552 | 59/18723 | 6.23e-03 | 2.29e-02 | 37 |
GO:00424401 | Esophagus | ESCC | pigment metabolic process | 50/8552 | 84/18723 | 7.34e-03 | 2.64e-02 | 50 |
GO:00421681 | Esophagus | ESCC | heme metabolic process | 27/8552 | 42/18723 | 1.16e-02 | 3.90e-02 | 27 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPOX | deletion | Frame_Shift_Del | novel | c.275delC | p.Pro92GlnfsTer40 | p.P92Qfs*40 | P50336 | protein_coding | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | ||
PPOX | SNV | Missense_Mutation | novel | c.709C>T | p.Pro237Ser | p.P237S | P50336 | protein_coding | tolerated(0.14) | benign(0.33) | TCGA-05-4405-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPOX | SNV | Missense_Mutation | c.1343N>C | p.Gly448Ala | p.G448A | P50336 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-78-7539-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
PPOX | SNV | Missense_Mutation | novel | c.697C>G | p.Leu233Val | p.L233V | P50336 | protein_coding | tolerated(0.11) | benign(0.251) | TCGA-91-6836-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPOX | SNV | Missense_Mutation | novel | c.1063N>C | p.Glu355Gln | p.E355Q | P50336 | protein_coding | tolerated(0.39) | benign(0.041) | TCGA-J1-A4AH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
PPOX | deletion | Frame_Shift_Del | c.1077delN | p.Pro361LeufsTer5 | p.P361Lfs*5 | P50336 | protein_coding | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |||
PPOX | SNV | Missense_Mutation | novel | c.220N>A | p.Leu74Met | p.L74M | P50336 | protein_coding | tolerated(1) | benign(0.038) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
PPOX | SNV | Missense_Mutation | c.614N>A | p.Ala205Glu | p.A205E | P50336 | protein_coding | tolerated(0.23) | benign(0.057) | TCGA-CN-A63V-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PPOX | SNV | Missense_Mutation | c.1258N>A | p.Pro420Thr | p.P420T | P50336 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-4357-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PPOX | SNV | Missense_Mutation | rs78028107 | c.232N>T | p.Leu78Phe | p.L78F | P50336 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5498 | PPOX | DRUGGABLE GENOME, ENZYME | Aminolevulinic Acid Hydrochloride | |||
5498 | PPOX | DRUGGABLE GENOME, ENZYME | givosiran | GIVOSIRAN | ||
5498 | PPOX | DRUGGABLE GENOME, ENZYME | Givosiran | GIVOSIRAN |
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