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Gene: PPM1G |
Gene summary for PPM1G |
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Gene information | Species | Human | Gene symbol | PPM1G | Gene ID | 5496 |
Gene name | protein phosphatase, Mg2+/Mn2+ dependent 1G | |
Gene Alias | PP2CG | |
Cytomap | 2p23.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | O15355 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5496 | PPM1G | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.43e-02 | 3.54e-01 | -0.0811 |
5496 | PPM1G | HTA11_347_2000001011 | Human | Colorectum | AD | 2.08e-05 | 2.89e-01 | -0.1954 |
5496 | PPM1G | HTA11_83_2000001011 | Human | Colorectum | SER | 2.22e-02 | 3.64e-01 | -0.1526 |
5496 | PPM1G | HTA11_696_2000001011 | Human | Colorectum | AD | 5.26e-05 | 4.58e-01 | -0.1464 |
5496 | PPM1G | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.64e-13 | 6.91e-01 | -0.059 |
5496 | PPM1G | HTA11_866_3004761011 | Human | Colorectum | AD | 6.64e-07 | 4.97e-01 | 0.096 |
5496 | PPM1G | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.18e-02 | 7.06e-01 | 0.0171 |
5496 | PPM1G | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.01e-12 | 6.40e-01 | 0.0674 |
5496 | PPM1G | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.59e-10 | 6.03e-01 | 0.294 |
5496 | PPM1G | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.66e-02 | 1.12e+00 | 0.3487 |
5496 | PPM1G | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.04e-03 | 4.52e-01 | 0.281 |
5496 | PPM1G | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.02e-15 | 8.30e-01 | 0.3859 |
5496 | PPM1G | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.45e-05 | 5.32e-01 | 0.2585 |
5496 | PPM1G | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.10e-09 | 5.33e-01 | 0.3005 |
5496 | PPM1G | A015-C-203 | Human | Colorectum | FAP | 7.21e-08 | -2.16e-01 | -0.1294 |
5496 | PPM1G | A001-C-108 | Human | Colorectum | FAP | 2.20e-03 | -9.42e-02 | -0.0272 |
5496 | PPM1G | A002-C-205 | Human | Colorectum | FAP | 1.08e-03 | -1.74e-01 | -0.1236 |
5496 | PPM1G | A015-C-104 | Human | Colorectum | FAP | 6.82e-08 | -1.18e-01 | -0.1899 |
5496 | PPM1G | A001-C-014 | Human | Colorectum | FAP | 6.36e-05 | -1.73e-01 | 0.0135 |
5496 | PPM1G | A002-C-016 | Human | Colorectum | FAP | 2.98e-05 | -1.34e-01 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
GO:0006470 | Colorectum | AD | protein dephosphorylation | 88/3918 | 281/18723 | 2.56e-05 | 4.89e-04 | 88 |
GO:00064701 | Colorectum | SER | protein dephosphorylation | 65/2897 | 281/18723 | 4.44e-04 | 6.51e-03 | 65 |
GO:00163111 | Colorectum | SER | dephosphorylation | 86/2897 | 417/18723 | 2.73e-03 | 2.46e-02 | 86 |
GO:00064702 | Colorectum | MSS | protein dephosphorylation | 73/3467 | 281/18723 | 1.15e-03 | 1.12e-02 | 73 |
GO:00163112 | Colorectum | MSS | dephosphorylation | 101/3467 | 417/18723 | 1.98e-03 | 1.70e-02 | 101 |
GO:00064703 | Colorectum | MSI-H | protein dephosphorylation | 34/1319 | 281/18723 | 1.43e-03 | 2.22e-02 | 34 |
GO:00163113 | Colorectum | FAP | dephosphorylation | 95/2622 | 417/18723 | 7.07e-07 | 3.32e-05 | 95 |
GO:00064704 | Colorectum | FAP | protein dephosphorylation | 69/2622 | 281/18723 | 1.47e-06 | 6.39e-05 | 69 |
GO:000647017 | Esophagus | HGIN | protein dephosphorylation | 61/2587 | 281/18723 | 1.86e-04 | 3.51e-03 | 61 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:00359703 | Esophagus | ESCC | peptidyl-threonine dephosphorylation | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
GO:000647011 | Liver | Cirrhotic | protein dephosphorylation | 96/4634 | 281/18723 | 2.32e-04 | 2.11e-03 | 96 |
GO:001631111 | Liver | Cirrhotic | dephosphorylation | 130/4634 | 417/18723 | 1.58e-03 | 1.03e-02 | 130 |
GO:0035970 | Liver | Cirrhotic | peptidyl-threonine dephosphorylation | 9/4634 | 16/18723 | 6.94e-03 | 3.38e-02 | 9 |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
GO:000647021 | Liver | HCC | protein dephosphorylation | 162/7958 | 281/18723 | 1.91e-07 | 3.46e-06 | 162 |
GO:00359701 | Liver | HCC | peptidyl-threonine dephosphorylation | 13/7958 | 16/18723 | 1.84e-03 | 9.42e-03 | 13 |
GO:000647015 | Oral cavity | OSCC | protein dephosphorylation | 162/7305 | 281/18723 | 1.56e-10 | 4.56e-09 | 162 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPM1G | SNV | Missense_Mutation | novel | c.1426G>A | p.Val476Met | p.V476M | O15355 | protein_coding | tolerated(0.05) | possibly_damaging(0.894) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPM1G | SNV | Missense_Mutation | novel | c.595A>G | p.Thr199Ala | p.T199A | O15355 | protein_coding | tolerated(0.75) | benign(0.003) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPM1G | SNV | Missense_Mutation | rs772264870 | c.749N>A | p.Arg250Gln | p.R250Q | O15355 | protein_coding | tolerated(0.68) | benign(0.119) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPM1G | SNV | Missense_Mutation | novel | c.915N>A | p.Asp305Glu | p.D305E | O15355 | protein_coding | tolerated(1) | benign(0) | TCGA-SJ-A6ZI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPM1G | insertion | Frame_Shift_Ins | novel | c.1591_1592insG | p.Ala531GlyfsTer2 | p.A531Gfs*2 | O15355 | protein_coding | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | ||
PPM1G | SNV | Missense_Mutation | rs150808424 | c.800N>T | p.Ala267Val | p.A267V | O15355 | protein_coding | tolerated(0.37) | benign(0) | TCGA-05-4410-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPM1G | SNV | Missense_Mutation | novel | c.319A>T | p.Thr107Ser | p.T107S | O15355 | protein_coding | tolerated(0.58) | possibly_damaging(0.801) | TCGA-05-4432-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
PPM1G | SNV | Missense_Mutation | c.569N>T | p.Ala190Val | p.A190V | O15355 | protein_coding | tolerated(0.6) | benign(0.248) | TCGA-55-6969-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PPM1G | SNV | Missense_Mutation | c.1156A>G | p.Met386Val | p.M386V | O15355 | protein_coding | tolerated(0.16) | possibly_damaging(0.893) | TCGA-69-7978-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PPM1G | SNV | Missense_Mutation | novel | c.1515N>G | p.Phe505Leu | p.F505L | O15355 | protein_coding | tolerated(0.35) | benign(0.007) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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