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Gene: POLRMT |
Gene summary for POLRMT |
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Gene information | Species | Human | Gene symbol | POLRMT | Gene ID | 5442 |
Gene name | RNA polymerase mitochondrial | |
Gene Alias | APOLMT | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000959 | UniProtAcc | O00411 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5442 | POLRMT | LZE5T | Human | Esophagus | ESCC | 1.54e-04 | 2.46e-01 | 0.0514 |
5442 | POLRMT | LZE7T | Human | Esophagus | ESCC | 6.33e-03 | 1.24e-01 | 0.0667 |
5442 | POLRMT | LZE8T | Human | Esophagus | ESCC | 4.41e-02 | 7.57e-02 | 0.067 |
5442 | POLRMT | LZE24T | Human | Esophagus | ESCC | 2.42e-13 | 2.51e-01 | 0.0596 |
5442 | POLRMT | P1T-E | Human | Esophagus | ESCC | 1.64e-05 | 2.25e-01 | 0.0875 |
5442 | POLRMT | P2T-E | Human | Esophagus | ESCC | 3.50e-02 | 6.12e-02 | 0.1177 |
5442 | POLRMT | P4T-E | Human | Esophagus | ESCC | 2.81e-07 | 1.36e-01 | 0.1323 |
5442 | POLRMT | P5T-E | Human | Esophagus | ESCC | 3.75e-03 | 7.30e-02 | 0.1327 |
5442 | POLRMT | P8T-E | Human | Esophagus | ESCC | 1.78e-03 | 7.67e-02 | 0.0889 |
5442 | POLRMT | P9T-E | Human | Esophagus | ESCC | 9.50e-13 | 2.19e-01 | 0.1131 |
5442 | POLRMT | P10T-E | Human | Esophagus | ESCC | 1.76e-12 | 1.95e-01 | 0.116 |
5442 | POLRMT | P11T-E | Human | Esophagus | ESCC | 6.08e-06 | 2.03e-01 | 0.1426 |
5442 | POLRMT | P12T-E | Human | Esophagus | ESCC | 1.13e-16 | 2.75e-01 | 0.1122 |
5442 | POLRMT | P15T-E | Human | Esophagus | ESCC | 1.67e-14 | 2.61e-01 | 0.1149 |
5442 | POLRMT | P16T-E | Human | Esophagus | ESCC | 2.96e-14 | 1.65e-01 | 0.1153 |
5442 | POLRMT | P17T-E | Human | Esophagus | ESCC | 2.26e-13 | 3.81e-01 | 0.1278 |
5442 | POLRMT | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 2.49e-01 | 0.1662 |
5442 | POLRMT | P20T-E | Human | Esophagus | ESCC | 3.75e-11 | 2.28e-01 | 0.1124 |
5442 | POLRMT | P21T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.37e-01 | 0.1617 |
5442 | POLRMT | P22T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.15e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:00009592 | Esophagus | ESCC | mitochondrial RNA metabolic process | 39/8552 | 49/18723 | 1.20e-06 | 1.49e-05 | 39 |
GO:01400531 | Liver | HCC | mitochondrial gene expression | 82/7958 | 108/18723 | 1.49e-12 | 7.20e-11 | 82 |
GO:0000959 | Liver | HCC | mitochondrial RNA metabolic process | 30/7958 | 49/18723 | 6.31e-03 | 2.57e-02 | 30 |
GO:01400536 | Thyroid | PTC | mitochondrial gene expression | 51/5968 | 108/18723 | 6.04e-04 | 3.83e-03 | 51 |
GO:014005314 | Thyroid | ATC | mitochondrial gene expression | 51/6293 | 108/18723 | 2.26e-03 | 1.06e-02 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLRMT | SNV | Missense_Mutation | c.1108N>G | p.Thr370Ala | p.T370A | O00411 | protein_coding | tolerated(0.1) | benign(0.079) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
POLRMT | SNV | Missense_Mutation | c.1520N>A | p.Arg507His | p.R507H | O00411 | protein_coding | deleterious(0) | benign(0.158) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
POLRMT | SNV | Missense_Mutation | rs775039991 | c.2591N>T | p.Ala864Val | p.A864V | O00411 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POLRMT | SNV | Missense_Mutation | rs556603744 | c.899N>T | p.Ala300Val | p.A300V | O00411 | protein_coding | deleterious(0) | possibly_damaging(0.881) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POLRMT | SNV | Missense_Mutation | c.1183N>T | p.Thr395Ser | p.T395S | O00411 | protein_coding | tolerated(0.07) | benign(0) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
POLRMT | SNV | Missense_Mutation | c.3230C>G | p.Pro1077Arg | p.P1077R | O00411 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-QG-A5YV-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | CR | |
POLRMT | SNV | Missense_Mutation | c.2492G>A | p.Arg831His | p.R831H | O00411 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-QG-A5YV-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | CR | |
POLRMT | SNV | Missense_Mutation | c.758G>A | p.Arg253Gln | p.R253Q | O00411 | protein_coding | tolerated(0.65) | benign(0.001) | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
POLRMT | SNV | Missense_Mutation | c.3658N>A | p.Glu1220Lys | p.E1220K | O00411 | protein_coding | tolerated(0.31) | benign(0.017) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
POLRMT | SNV | Missense_Mutation | novel | c.3662A>G | p.Gln1221Arg | p.Q1221R | O00411 | protein_coding | tolerated(0.41) | benign(0.02) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5442 | POLRMT | NA | 2',2'-DIFLUORODEOXYCYTIDINE 5'-TRIPHOSPHATE | 2',2'-DIFLUORODEOXYCYTIDINE 5'-TRIPHOSPHATE | 25667954 |
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