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Gene: POLR3D |
Gene summary for POLR3D |
Gene summary. |
Gene information | Species | Human | Gene symbol | POLR3D | Gene ID | 661 |
Gene name | RNA polymerase III subunit D | |
Gene Alias | BN51T | |
Cytomap | 8p21.3 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | P05423 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
661 | POLR3D | LZE4T | Human | Esophagus | ESCC | 8.47e-04 | 8.60e-02 | 0.0811 |
661 | POLR3D | LZE8T | Human | Esophagus | ESCC | 5.21e-03 | 1.66e-01 | 0.067 |
661 | POLR3D | LZE20T | Human | Esophagus | ESCC | 3.03e-06 | 1.30e-01 | 0.0662 |
661 | POLR3D | LZE22T | Human | Esophagus | ESCC | 1.52e-03 | 2.06e-01 | 0.068 |
661 | POLR3D | LZE24T | Human | Esophagus | ESCC | 1.63e-11 | 3.64e-01 | 0.0596 |
661 | POLR3D | LZE21T | Human | Esophagus | ESCC | 4.73e-03 | 2.08e-01 | 0.0655 |
661 | POLR3D | P1T-E | Human | Esophagus | ESCC | 4.35e-07 | 2.50e-01 | 0.0875 |
661 | POLR3D | P2T-E | Human | Esophagus | ESCC | 8.93e-25 | 4.24e-01 | 0.1177 |
661 | POLR3D | P4T-E | Human | Esophagus | ESCC | 2.52e-19 | 4.41e-01 | 0.1323 |
661 | POLR3D | P5T-E | Human | Esophagus | ESCC | 6.25e-08 | 1.64e-01 | 0.1327 |
661 | POLR3D | P8T-E | Human | Esophagus | ESCC | 1.05e-10 | 1.91e-01 | 0.0889 |
661 | POLR3D | P9T-E | Human | Esophagus | ESCC | 7.62e-10 | 2.39e-01 | 0.1131 |
661 | POLR3D | P10T-E | Human | Esophagus | ESCC | 1.10e-22 | 4.39e-01 | 0.116 |
661 | POLR3D | P11T-E | Human | Esophagus | ESCC | 8.20e-07 | 3.44e-01 | 0.1426 |
661 | POLR3D | P12T-E | Human | Esophagus | ESCC | 6.20e-15 | 2.59e-01 | 0.1122 |
661 | POLR3D | P15T-E | Human | Esophagus | ESCC | 1.62e-04 | 1.35e-01 | 0.1149 |
661 | POLR3D | P16T-E | Human | Esophagus | ESCC | 1.87e-12 | 3.51e-01 | 0.1153 |
661 | POLR3D | P17T-E | Human | Esophagus | ESCC | 6.75e-09 | 4.11e-01 | 0.1278 |
661 | POLR3D | P19T-E | Human | Esophagus | ESCC | 1.61e-06 | 5.27e-01 | 0.1662 |
661 | POLR3D | P20T-E | Human | Esophagus | ESCC | 6.49e-18 | 3.66e-01 | 0.1124 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:01405465 | Esophagus | ESCC | defense response to symbiont | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:00063833 | Esophagus | ESCC | transcription by RNA polymerase III | 41/8552 | 46/18723 | 7.69e-10 | 1.90e-08 | 41 |
GO:00028318 | Esophagus | ESCC | regulation of response to biotic stimulus | 191/8552 | 327/18723 | 2.12e-06 | 2.45e-05 | 191 |
GO:003248112 | Esophagus | ESCC | positive regulation of type I interferon production | 42/8552 | 58/18723 | 3.27e-05 | 2.70e-04 | 42 |
GO:00326084 | Esophagus | ESCC | interferon-beta production | 40/8552 | 56/18723 | 8.36e-05 | 6.08e-04 | 40 |
GO:00326484 | Esophagus | ESCC | regulation of interferon-beta production | 40/8552 | 56/18723 | 8.36e-05 | 6.08e-04 | 40 |
GO:003247912 | Esophagus | ESCC | regulation of type I interferon production | 61/8552 | 95/18723 | 2.05e-04 | 1.29e-03 | 61 |
GO:003260612 | Esophagus | ESCC | type I interferon production | 61/8552 | 95/18723 | 2.05e-04 | 1.29e-03 | 61 |
GO:00327284 | Esophagus | ESCC | positive regulation of interferon-beta production | 29/8552 | 39/18723 | 2.59e-04 | 1.58e-03 | 29 |
GO:00450885 | Esophagus | ESCC | regulation of innate immune response | 125/8552 | 218/18723 | 3.34e-04 | 1.96e-03 | 125 |
GO:000181916 | Esophagus | ESCC | positive regulation of cytokine production | 244/8552 | 467/18723 | 2.29e-03 | 1.01e-02 | 244 |
GO:000961515 | Oral cavity | OSCC | response to virus | 215/7305 | 367/18723 | 1.63e-14 | 9.41e-13 | 215 |
GO:00516074 | Oral cavity | OSCC | defense response to virus | 154/7305 | 265/18723 | 1.96e-10 | 5.63e-09 | 154 |
GO:01405464 | Oral cavity | OSCC | defense response to symbiont | 154/7305 | 265/18723 | 1.96e-10 | 5.63e-09 | 154 |
GO:00028317 | Oral cavity | OSCC | regulation of response to biotic stimulus | 177/7305 | 327/18723 | 1.73e-08 | 3.43e-07 | 177 |
GO:00063832 | Oral cavity | OSCC | transcription by RNA polymerase III | 34/7305 | 46/18723 | 1.61e-06 | 2.11e-05 | 34 |
GO:00450884 | Oral cavity | OSCC | regulation of innate immune response | 116/7305 | 218/18723 | 1.36e-05 | 1.37e-04 | 116 |
GO:00326083 | Oral cavity | OSCC | interferon-beta production | 37/7305 | 56/18723 | 3.74e-05 | 3.32e-04 | 37 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0302021 | Esophagus | ESCC | RNA polymerase | 28/4205 | 34/8465 | 8.19e-05 | 3.35e-04 | 1.71e-04 | 28 |
hsa046234 | Esophagus | ESCC | Cytosolic DNA-sensing pathway | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa0302031 | Esophagus | ESCC | RNA polymerase | 28/4205 | 34/8465 | 8.19e-05 | 3.35e-04 | 1.71e-04 | 28 |
hsa0462311 | Esophagus | ESCC | Cytosolic DNA-sensing pathway | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
hsa04623 | Oral cavity | OSCC | Cytosolic DNA-sensing pathway | 44/3704 | 75/8465 | 6.44e-03 | 1.51e-02 | 7.68e-03 | 44 |
hsa046231 | Oral cavity | OSCC | Cytosolic DNA-sensing pathway | 44/3704 | 75/8465 | 6.44e-03 | 1.51e-02 | 7.68e-03 | 44 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLR3D | SNV | Missense_Mutation | rs778120628 | c.1159N>T | p.Pro387Ser | p.P387S | P05423 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EL-A3CR-01 | Thyroid | thyroid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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