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Gene: PNKD |
Gene summary for PNKD |
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Gene information | Species | Human | Gene symbol | PNKD | Gene ID | 25953 |
Gene name | PNKD metallo-beta-lactamase domain containing | |
Gene Alias | BRP17 | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q8N490 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25953 | PNKD | GSM4909281 | Human | Breast | IDC | 2.29e-12 | 5.15e-01 | 0.21 |
25953 | PNKD | GSM4909296 | Human | Breast | IDC | 1.26e-11 | 1.39e-01 | 0.1524 |
25953 | PNKD | GSM4909297 | Human | Breast | IDC | 1.37e-10 | 9.84e-02 | 0.1517 |
25953 | PNKD | GSM4909301 | Human | Breast | IDC | 2.73e-06 | 3.55e-01 | 0.1577 |
25953 | PNKD | GSM4909306 | Human | Breast | IDC | 2.03e-02 | 3.47e-01 | 0.1564 |
25953 | PNKD | GSM4909311 | Human | Breast | IDC | 1.77e-29 | -2.22e-01 | 0.1534 |
25953 | PNKD | GSM4909312 | Human | Breast | IDC | 7.69e-08 | -6.01e-02 | 0.1552 |
25953 | PNKD | GSM4909315 | Human | Breast | IDC | 1.34e-03 | 3.76e-01 | 0.21 |
25953 | PNKD | GSM4909316 | Human | Breast | IDC | 2.87e-06 | 4.45e-01 | 0.21 |
25953 | PNKD | GSM4909318 | Human | Breast | IDC | 2.29e-05 | 5.32e-01 | 0.2031 |
25953 | PNKD | GSM4909319 | Human | Breast | IDC | 1.51e-37 | -4.10e-02 | 0.1563 |
25953 | PNKD | GSM4909321 | Human | Breast | IDC | 5.43e-14 | -1.51e-01 | 0.1559 |
25953 | PNKD | NCCBC14 | Human | Breast | DCIS | 2.89e-05 | 6.52e-02 | 0.2021 |
25953 | PNKD | NCCBC5 | Human | Breast | DCIS | 1.35e-07 | -3.41e-02 | 0.2046 |
25953 | PNKD | P1 | Human | Breast | IDC | 2.22e-16 | -2.22e-01 | 0.1527 |
25953 | PNKD | DCIS2 | Human | Breast | DCIS | 5.73e-58 | 6.20e-02 | 0.0085 |
25953 | PNKD | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.55e-08 | 5.99e-01 | -0.1808 |
25953 | PNKD | HTA11_347_2000001011 | Human | Colorectum | AD | 5.00e-17 | 5.47e-01 | -0.1954 |
25953 | PNKD | HTA11_411_2000001011 | Human | Colorectum | SER | 1.28e-03 | 9.00e-01 | -0.2602 |
25953 | PNKD | HTA11_696_2000001011 | Human | Colorectum | AD | 4.66e-06 | 4.28e-01 | -0.1464 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0006081 | Colorectum | AD | cellular aldehyde metabolic process | 22/3918 | 60/18723 | 3.64e-03 | 2.60e-02 | 22 |
GO:00442821 | Colorectum | SER | small molecule catabolic process | 87/2897 | 376/18723 | 5.31e-05 | 1.27e-03 | 87 |
GO:0051051 | Colorectum | SER | negative regulation of transport | 98/2897 | 470/18723 | 1.01e-03 | 1.19e-02 | 98 |
GO:1903531 | Colorectum | SER | negative regulation of secretion by cell | 35/2897 | 147/18723 | 5.21e-03 | 3.95e-02 | 35 |
GO:0051048 | Colorectum | SER | negative regulation of secretion | 39/2897 | 171/18723 | 7.17e-03 | 4.99e-02 | 39 |
GO:00442822 | Colorectum | MSS | small molecule catabolic process | 94/3467 | 376/18723 | 9.85e-04 | 9.86e-03 | 94 |
GO:00060811 | Colorectum | MSS | cellular aldehyde metabolic process | 21/3467 | 60/18723 | 1.81e-03 | 1.60e-02 | 21 |
GO:00510511 | Colorectum | MSS | negative regulation of transport | 110/3467 | 470/18723 | 4.20e-03 | 3.04e-02 | 110 |
GO:0023061 | Colorectum | FAP | signal release | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
GO:00442823 | Colorectum | FAP | small molecule catabolic process | 77/2622 | 376/18723 | 3.25e-04 | 4.16e-03 | 77 |
GO:00510512 | Colorectum | FAP | negative regulation of transport | 91/2622 | 470/18723 | 7.09e-04 | 7.64e-03 | 91 |
GO:00421805 | Esophagus | ESCC | cellular ketone metabolic process | 120/8552 | 211/18723 | 6.70e-04 | 3.55e-03 | 120 |
GO:00060818 | Esophagus | ESCC | cellular aldehyde metabolic process | 40/8552 | 60/18723 | 8.30e-04 | 4.28e-03 | 40 |
GO:00442827 | Esophagus | ESCC | small molecule catabolic process | 201/8552 | 376/18723 | 1.35e-03 | 6.41e-03 | 201 |
GO:004428211 | Liver | Cirrhotic | small molecule catabolic process | 151/4634 | 376/18723 | 2.20e-11 | 1.34e-09 | 151 |
GO:004218011 | Liver | Cirrhotic | cellular ketone metabolic process | 80/4634 | 211/18723 | 1.40e-05 | 1.95e-04 | 80 |
GO:00060815 | Liver | Cirrhotic | cellular aldehyde metabolic process | 28/4634 | 60/18723 | 1.83e-04 | 1.71e-03 | 28 |
GO:0044106 | Liver | Cirrhotic | cellular amine metabolic process | 43/4634 | 113/18723 | 1.15e-03 | 7.83e-03 | 43 |
GO:0046185 | Liver | Cirrhotic | aldehyde catabolic process | 8/4634 | 12/18723 | 2.59e-03 | 1.53e-02 | 8 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PNKD | SNV | Missense_Mutation | novel | c.847N>A | p.Asp283Asn | p.D283N | Q8N490 | protein_coding | tolerated(0.07) | probably_damaging(0.966) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PNKD | SNV | Missense_Mutation | novel | c.395N>A | p.Ser132Asn | p.S132N | Q8N490 | protein_coding | deleterious(0.03) | probably_damaging(0.977) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PNKD | SNV | Missense_Mutation | c.1085N>T | p.Gly362Val | p.G362V | Q8N490 | protein_coding | tolerated(0.08) | possibly_damaging(0.655) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PNKD | SNV | Missense_Mutation | c.1004N>G | p.Glu335Gly | p.E335G | Q8N490 | protein_coding | deleterious(0.01) | probably_damaging(0.921) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
PNKD | SNV | Missense_Mutation | c.997C>A | p.Leu333Met | p.L333M | Q8N490 | protein_coding | deleterious(0.03) | possibly_damaging(0.694) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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