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Gene: PMPCB |
Gene summary for PMPCB |
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Gene information | Species | Human | Gene symbol | PMPCB | Gene ID | 9512 |
Gene name | peptidase, mitochondrial processing subunit beta | |
Gene Alias | Beta-MPP | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | B3KM34 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9512 | PMPCB | LZE2T | Human | Esophagus | ESCC | 8.94e-10 | 6.52e-01 | 0.082 |
9512 | PMPCB | LZE4T | Human | Esophagus | ESCC | 1.14e-12 | 3.81e-01 | 0.0811 |
9512 | PMPCB | LZE5T | Human | Esophagus | ESCC | 5.38e-05 | 1.48e-01 | 0.0514 |
9512 | PMPCB | LZE7T | Human | Esophagus | ESCC | 6.40e-09 | 5.69e-01 | 0.0667 |
9512 | PMPCB | LZE8T | Human | Esophagus | ESCC | 3.65e-07 | 2.02e-01 | 0.067 |
9512 | PMPCB | LZE20T | Human | Esophagus | ESCC | 7.50e-06 | 1.95e-01 | 0.0662 |
9512 | PMPCB | LZE22T | Human | Esophagus | ESCC | 1.04e-03 | 3.21e-01 | 0.068 |
9512 | PMPCB | LZE24T | Human | Esophagus | ESCC | 1.42e-20 | 6.05e-01 | 0.0596 |
9512 | PMPCB | P1T-E | Human | Esophagus | ESCC | 3.65e-06 | 5.09e-01 | 0.0875 |
9512 | PMPCB | P2T-E | Human | Esophagus | ESCC | 1.89e-80 | 1.47e+00 | 0.1177 |
9512 | PMPCB | P4T-E | Human | Esophagus | ESCC | 9.49e-41 | 1.02e+00 | 0.1323 |
9512 | PMPCB | P5T-E | Human | Esophagus | ESCC | 5.99e-22 | 5.01e-01 | 0.1327 |
9512 | PMPCB | P8T-E | Human | Esophagus | ESCC | 3.17e-22 | 3.29e-01 | 0.0889 |
9512 | PMPCB | P9T-E | Human | Esophagus | ESCC | 2.01e-16 | 4.61e-01 | 0.1131 |
9512 | PMPCB | P10T-E | Human | Esophagus | ESCC | 2.49e-32 | 5.49e-01 | 0.116 |
9512 | PMPCB | P11T-E | Human | Esophagus | ESCC | 2.16e-15 | 5.86e-01 | 0.1426 |
9512 | PMPCB | P12T-E | Human | Esophagus | ESCC | 1.01e-51 | 1.09e+00 | 0.1122 |
9512 | PMPCB | P15T-E | Human | Esophagus | ESCC | 3.38e-52 | 1.24e+00 | 0.1149 |
9512 | PMPCB | P16T-E | Human | Esophagus | ESCC | 9.40e-61 | 1.12e+00 | 0.1153 |
9512 | PMPCB | P17T-E | Human | Esophagus | ESCC | 1.09e-19 | 1.01e+00 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:0072655110 | Esophagus | ESCC | establishment of protein localization to mitochondrion | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:0070585110 | Esophagus | ESCC | protein localization to mitochondrion | 100/8552 | 125/18723 | 2.96e-15 | 1.77e-13 | 100 |
GO:0006626110 | Esophagus | ESCC | protein targeting to mitochondrion | 81/8552 | 100/18723 | 3.60e-13 | 1.67e-11 | 81 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:007259412 | Liver | Cirrhotic | establishment of protein localization to organelle | 189/4634 | 422/18723 | 1.01e-19 | 2.45e-17 | 189 |
GO:00066057 | Liver | Cirrhotic | protein targeting | 148/4634 | 314/18723 | 3.86e-18 | 6.20e-16 | 148 |
GO:00068397 | Liver | Cirrhotic | mitochondrial transport | 112/4634 | 254/18723 | 1.03e-11 | 6.66e-10 | 112 |
GO:00705857 | Liver | Cirrhotic | protein localization to mitochondrion | 65/4634 | 125/18723 | 4.91e-11 | 2.77e-09 | 65 |
GO:00726557 | Liver | Cirrhotic | establishment of protein localization to mitochondrion | 63/4634 | 120/18723 | 5.70e-11 | 3.19e-09 | 63 |
GO:00516046 | Liver | Cirrhotic | protein maturation | 121/4634 | 294/18723 | 3.54e-10 | 1.68e-08 | 121 |
GO:00066267 | Liver | Cirrhotic | protein targeting to mitochondrion | 53/4634 | 100/18723 | 1.19e-09 | 5.27e-08 | 53 |
GO:00164853 | Liver | Cirrhotic | protein processing | 85/4634 | 225/18723 | 9.01e-06 | 1.32e-04 | 85 |
GO:007259422 | Liver | HCC | establishment of protein localization to organelle | 299/7958 | 422/18723 | 1.06e-32 | 6.10e-30 | 299 |
GO:000660512 | Liver | HCC | protein targeting | 219/7958 | 314/18723 | 7.74e-23 | 1.49e-20 | 219 |
GO:000683912 | Liver | HCC | mitochondrial transport | 184/7958 | 254/18723 | 2.30e-22 | 3.83e-20 | 184 |
GO:007265512 | Liver | HCC | establishment of protein localization to mitochondrion | 98/7958 | 120/18723 | 1.18e-18 | 1.46e-16 | 98 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PMPCB | SNV | Missense_Mutation | c.370N>A | p.Glu124Lys | p.E124K | O75439 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-56-6546-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PMPCB | SNV | Missense_Mutation | novel | c.837C>A | p.Phe279Leu | p.F279L | O75439 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-56-7579-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | PD |
PMPCB | SNV | Missense_Mutation | novel | c.1224N>C | p.Met408Ile | p.M408I | O75439 | protein_coding | tolerated(0.22) | benign(0.035) | TCGA-66-2769-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
PMPCB | SNV | Missense_Mutation | novel | c.217G>A | p.Asp73Asn | p.D73N | O75439 | protein_coding | tolerated(0.49) | benign(0.012) | TCGA-85-A5B5-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PMPCB | deletion | Frame_Shift_Del | novel | c.695delN | p.Thr232AsnfsTer8 | p.T232Nfs*8 | O75439 | protein_coding | TCGA-55-8205-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
PMPCB | deletion | Frame_Shift_Del | novel | c.697_700delNNNN | p.His233IlefsTer6 | p.H233Ifs*6 | O75439 | protein_coding | TCGA-55-8205-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
PMPCB | insertion | In_Frame_Ins | novel | c.990_991insCCTCTAGTTAAG | p.Gly330_Met331insProLeuValLys | p.G330_M331insPLVK | O75439 | protein_coding | TCGA-56-8504-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
PMPCB | insertion | Frame_Shift_Ins | novel | c.1222_1223insT | p.Met408IlefsTer6 | p.M408Ifs*6 | O75439 | protein_coding | TCGA-CR-6477-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | ||
PMPCB | SNV | Missense_Mutation | c.772T>C | p.Phe258Leu | p.F258L | O75439 | protein_coding | deleterious(0.04) | benign(0) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PMPCB | deletion | In_Frame_Del | novel | c.100_105delNNNNNN | p.Ser34_Leu35del | p.S34_L35del | O75439 | protein_coding | TCGA-KB-A93J-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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