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Gene: PLP1 |
Gene summary for PLP1 |
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Gene information | Species | Human | Gene symbol | PLP1 | Gene ID | 5354 |
Gene name | proteolipid protein 1 | |
Gene Alias | GPM6C | |
Cytomap | Xq22.2 | |
Gene Type | protein-coding | GO ID | GO:0001676 | UniProtAcc | A8K9L3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5354 | PLP1 | ATC13 | Human | Thyroid | ATC | 2.80e-17 | 5.30e-01 | 0.34 |
5354 | PLP1 | ATC5 | Human | Thyroid | ATC | 1.20e-21 | 5.73e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000218110 | Cervix | CC | cytoplasmic translation | 96/2311 | 148/18723 | 4.87e-51 | 2.91e-47 | 96 |
GO:003367410 | Cervix | CC | positive regulation of kinase activity | 101/2311 | 467/18723 | 8.66e-09 | 7.22e-07 | 101 |
GO:00458608 | Cervix | CC | positive regulation of protein kinase activity | 85/2311 | 386/18723 | 5.61e-08 | 3.29e-06 | 85 |
GO:000218115 | Cervix | HSIL_HPV | cytoplasmic translation | 86/737 | 148/18723 | 3.97e-82 | 1.91e-78 | 86 |
GO:003367413 | Cervix | HSIL_HPV | positive regulation of kinase activity | 34/737 | 467/18723 | 4.49e-04 | 6.63e-03 | 34 |
GO:004586013 | Cervix | HSIL_HPV | positive regulation of protein kinase activity | 27/737 | 386/18723 | 2.93e-03 | 2.74e-02 | 27 |
GO:00064148 | Cervix | HSIL_HPV | translational elongation | 7/737 | 55/18723 | 5.59e-03 | 4.47e-02 | 7 |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:0033674 | Colorectum | AD | positive regulation of kinase activity | 131/3918 | 467/18723 | 1.28e-04 | 1.85e-03 | 131 |
GO:0045860 | Colorectum | AD | positive regulation of protein kinase activity | 107/3918 | 386/18723 | 8.01e-04 | 7.92e-03 | 107 |
GO:0006414 | Colorectum | AD | translational elongation | 21/3918 | 55/18723 | 2.53e-03 | 1.93e-02 | 21 |
GO:00021811 | Colorectum | SER | cytoplasmic translation | 102/2897 | 148/18723 | 1.38e-48 | 8.49e-45 | 102 |
GO:00336741 | Colorectum | SER | positive regulation of kinase activity | 95/2897 | 467/18723 | 2.62e-03 | 2.41e-02 | 95 |
GO:00064141 | Colorectum | SER | translational elongation | 17/2897 | 55/18723 | 3.00e-03 | 2.65e-02 | 17 |
GO:00458601 | Colorectum | SER | positive regulation of protein kinase activity | 79/2897 | 386/18723 | 4.85e-03 | 3.79e-02 | 79 |
GO:00021812 | Colorectum | MSS | cytoplasmic translation | 108/3467 | 148/18723 | 1.78e-47 | 1.11e-43 | 108 |
GO:00336742 | Colorectum | MSS | positive regulation of kinase activity | 122/3467 | 467/18723 | 2.50e-05 | 5.21e-04 | 122 |
GO:00458602 | Colorectum | MSS | positive regulation of protein kinase activity | 102/3467 | 386/18723 | 6.93e-05 | 1.20e-03 | 102 |
GO:00064142 | Colorectum | MSS | translational elongation | 19/3467 | 55/18723 | 3.47e-03 | 2.59e-02 | 19 |
GO:00021813 | Colorectum | MSI-H | cytoplasmic translation | 100/1319 | 148/18723 | 1.50e-79 | 8.31e-76 | 100 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLP1 | SNV | Missense_Mutation | c.316N>G | p.Thr106Ala | p.T106A | P60201 | protein_coding | tolerated(0.23) | benign(0.006) | TCGA-DD-A116-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
PLP1 | SNV | Missense_Mutation | c.543G>T | p.Trp181Cys | p.W181C | P60201 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-NI-A4U2-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
PLP1 | SNV | Missense_Mutation | c.419N>G | p.His140Arg | p.H140R | P60201 | protein_coding | tolerated(0.8) | benign(0) | TCGA-50-5049-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PLP1 | SNV | Missense_Mutation | c.391N>G | p.Gln131Glu | p.Q131E | P60201 | protein_coding | tolerated_low_confidence(1) | benign(0.003) | TCGA-55-8208-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PLP1 | SNV | Missense_Mutation | c.818G>A | p.Arg273Gln | p.R273Q | P60201 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLP1 | SNV | Missense_Mutation | c.489G>T | p.Trp163Cys | p.W163C | P60201 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-L9-A443-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PLP1 | SNV | Missense_Mutation | c.662G>T | p.Gly221Val | p.G221V | P60201 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-33-4533-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLP1 | SNV | Missense_Mutation | novel | c.428G>T | p.Gly143Val | p.G143V | P60201 | protein_coding | tolerated(0.16) | probably_damaging(0.999) | TCGA-43-7658-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PLP1 | SNV | Missense_Mutation | novel | c.811N>C | p.Met271Leu | p.M271L | P60201 | protein_coding | tolerated(1) | benign(0.001) | TCGA-85-8048-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PLP1 | SNV | Missense_Mutation | c.205N>A | p.Gln69Lys | p.Q69K | P60201 | protein_coding | tolerated(0.43) | possibly_damaging(0.468) | TCGA-96-7544-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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