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Gene: PKNOX1 |
Gene summary for PKNOX1 |
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Gene information | Species | Human | Gene symbol | PKNOX1 | Gene ID | 5316 |
Gene name | PBX/knotted 1 homeobox 1 | |
Gene Alias | PREP1 | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | B4DGV5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5316 | PKNOX1 | LZE4T | Human | Esophagus | ESCC | 3.56e-05 | 1.65e-01 | 0.0811 |
5316 | PKNOX1 | LZE7T | Human | Esophagus | ESCC | 2.67e-08 | 2.53e-01 | 0.0667 |
5316 | PKNOX1 | LZE24T | Human | Esophagus | ESCC | 1.36e-06 | 2.44e-01 | 0.0596 |
5316 | PKNOX1 | P1T-E | Human | Esophagus | ESCC | 7.15e-05 | 3.84e-01 | 0.0875 |
5316 | PKNOX1 | P2T-E | Human | Esophagus | ESCC | 1.17e-17 | 3.34e-01 | 0.1177 |
5316 | PKNOX1 | P4T-E | Human | Esophagus | ESCC | 3.48e-12 | 2.50e-01 | 0.1323 |
5316 | PKNOX1 | P5T-E | Human | Esophagus | ESCC | 2.09e-13 | 1.50e-01 | 0.1327 |
5316 | PKNOX1 | P8T-E | Human | Esophagus | ESCC | 1.16e-15 | 1.55e-01 | 0.0889 |
5316 | PKNOX1 | P9T-E | Human | Esophagus | ESCC | 5.69e-12 | 2.24e-01 | 0.1131 |
5316 | PKNOX1 | P10T-E | Human | Esophagus | ESCC | 2.56e-22 | 3.50e-01 | 0.116 |
5316 | PKNOX1 | P11T-E | Human | Esophagus | ESCC | 6.79e-07 | 3.28e-01 | 0.1426 |
5316 | PKNOX1 | P12T-E | Human | Esophagus | ESCC | 2.15e-14 | 2.55e-01 | 0.1122 |
5316 | PKNOX1 | P15T-E | Human | Esophagus | ESCC | 4.49e-07 | 2.10e-01 | 0.1149 |
5316 | PKNOX1 | P16T-E | Human | Esophagus | ESCC | 2.43e-06 | 1.37e-01 | 0.1153 |
5316 | PKNOX1 | P20T-E | Human | Esophagus | ESCC | 1.24e-11 | 3.05e-01 | 0.1124 |
5316 | PKNOX1 | P21T-E | Human | Esophagus | ESCC | 1.14e-15 | 2.74e-01 | 0.1617 |
5316 | PKNOX1 | P22T-E | Human | Esophagus | ESCC | 1.65e-08 | 1.30e-01 | 0.1236 |
5316 | PKNOX1 | P23T-E | Human | Esophagus | ESCC | 1.21e-09 | 1.81e-01 | 0.108 |
5316 | PKNOX1 | P24T-E | Human | Esophagus | ESCC | 1.13e-10 | 1.70e-01 | 0.1287 |
5316 | PKNOX1 | P26T-E | Human | Esophagus | ESCC | 3.93e-09 | 1.72e-01 | 0.1276 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030099111 | Esophagus | ESCC | myeloid cell differentiation | 232/8552 | 381/18723 | 1.22e-09 | 2.90e-08 | 232 |
GO:0002262111 | Esophagus | ESCC | myeloid cell homeostasis | 104/8552 | 157/18723 | 1.49e-07 | 2.36e-06 | 104 |
GO:0034101111 | Esophagus | ESCC | erythrocyte homeostasis | 88/8552 | 129/18723 | 1.81e-07 | 2.84e-06 | 88 |
GO:0048872111 | Esophagus | ESCC | homeostasis of number of cells | 163/8552 | 272/18723 | 1.40e-06 | 1.69e-05 | 163 |
GO:0030218111 | Esophagus | ESCC | erythrocyte differentiation | 80/8552 | 120/18723 | 2.69e-06 | 3.08e-05 | 80 |
GO:004211018 | Esophagus | ESCC | T cell activation | 256/8552 | 487/18723 | 1.18e-03 | 5.87e-03 | 256 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
GO:00302176 | Esophagus | ESCC | T cell differentiation | 137/8552 | 257/18723 | 8.09e-03 | 2.87e-02 | 137 |
GO:00300984 | Esophagus | ESCC | lymphocyte differentiation | 192/8552 | 374/18723 | 1.52e-02 | 4.93e-02 | 192 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PKNOX1 | SNV | Missense_Mutation | novel | c.683C>T | p.Thr228Ile | p.T228I | P55347 | protein_coding | deleterious(0.02) | benign(0.022) | TCGA-22-0944-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PKNOX1 | SNV | Missense_Mutation | c.193N>A | p.Pro65Thr | p.P65T | P55347 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-51-4080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PKNOX1 | SNV | Missense_Mutation | c.1027N>G | p.Gln343Glu | p.Q343E | P55347 | protein_coding | deleterious(0.05) | benign(0.022) | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD | |
PKNOX1 | SNV | Missense_Mutation | c.1269N>G | p.His423Gln | p.H423Q | P55347 | protein_coding | deleterious_low_confidence(0.02) | benign(0.009) | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD | |
PKNOX1 | SNV | Missense_Mutation | rs754833123 | c.376N>T | p.Arg126Cys | p.R126C | P55347 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-VN-A88O-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
PKNOX1 | SNV | Missense_Mutation | c.287N>C | p.Phe96Ser | p.F96S | P55347 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PKNOX1 | SNV | Missense_Mutation | rs746447164 | c.577G>A | p.Ala193Thr | p.A193T | P55347 | protein_coding | tolerated(0.14) | possibly_damaging(0.505) | TCGA-BR-4363-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PKNOX1 | SNV | Missense_Mutation | c.695G>A | p.Gly232Glu | p.G232E | P55347 | protein_coding | deleterious(0.03) | possibly_damaging(0.846) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PKNOX1 | SNV | Missense_Mutation | rs763181221 | c.1090N>G | p.Met364Val | p.M364V | P55347 | protein_coding | tolerated(0.22) | benign(0) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PKNOX1 | SNV | Missense_Mutation | c.857N>G | p.Tyr286Cys | p.Y286C | P55347 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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