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Gene: PIGT |
Gene summary for PIGT |
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Gene information | Species | Human | Gene symbol | PIGT | Gene ID | 51604 |
Gene name | phosphatidylinositol glycan anchor biosynthesis class T | |
Gene Alias | CGI-06 | |
Cytomap | 20q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q969N2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51604 | PIGT | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.89e-03 | 1.67e-01 | 0.0155 |
51604 | PIGT | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.32e-04 | 3.18e-01 | -0.1808 |
51604 | PIGT | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.39e-08 | 4.49e-01 | -0.0811 |
51604 | PIGT | HTA11_78_2000001011 | Human | Colorectum | AD | 1.02e-07 | 4.85e-01 | -0.1088 |
51604 | PIGT | HTA11_347_2000001011 | Human | Colorectum | AD | 6.51e-21 | 5.92e-01 | -0.1954 |
51604 | PIGT | HTA11_411_2000001011 | Human | Colorectum | SER | 6.00e-08 | 9.67e-01 | -0.2602 |
51604 | PIGT | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.37e-03 | 5.40e-01 | -0.2196 |
51604 | PIGT | HTA11_83_2000001011 | Human | Colorectum | SER | 1.76e-05 | 5.49e-01 | -0.1526 |
51604 | PIGT | HTA11_696_2000001011 | Human | Colorectum | AD | 1.26e-20 | 6.43e-01 | -0.1464 |
51604 | PIGT | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.95e-12 | 5.92e-01 | -0.059 |
51604 | PIGT | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.20e-02 | 3.90e-01 | -0.0179 |
51604 | PIGT | HTA11_866_3004761011 | Human | Colorectum | AD | 2.69e-18 | 6.72e-01 | 0.096 |
51604 | PIGT | HTA11_10711_2000001011 | Human | Colorectum | AD | 8.05e-03 | 3.48e-01 | 0.0338 |
51604 | PIGT | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.04e-04 | 2.96e-01 | 0.0674 |
51604 | PIGT | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.23e-04 | 3.53e-01 | 0.281 |
51604 | PIGT | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.58e-31 | 1.09e+00 | 0.3859 |
51604 | PIGT | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.08e-07 | 6.78e-01 | 0.2585 |
51604 | PIGT | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.95e-08 | 3.88e-01 | 0.3005 |
51604 | PIGT | A015-C-104 | Human | Colorectum | FAP | 1.88e-02 | -5.33e-02 | -0.1899 |
51604 | PIGT | A002-C-116 | Human | Colorectum | FAP | 1.63e-02 | -8.81e-02 | -0.0452 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
GO:0051402 | Colorectum | AD | neuron apoptotic process | 77/3918 | 246/18723 | 8.07e-05 | 1.28e-03 | 77 |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:00709971 | Colorectum | SER | neuron death | 84/2897 | 361/18723 | 5.76e-05 | 1.35e-03 | 84 |
GO:00514021 | Colorectum | SER | neuron apoptotic process | 60/2897 | 246/18723 | 1.65e-04 | 3.13e-03 | 60 |
GO:0046486 | Colorectum | SER | glycerolipid metabolic process | 82/2897 | 392/18723 | 2.26e-03 | 2.17e-02 | 82 |
GO:00066441 | Colorectum | SER | phospholipid metabolic process | 79/2897 | 383/18723 | 3.94e-03 | 3.24e-02 | 79 |
GO:00450171 | Colorectum | SER | glycerolipid biosynthetic process | 55/2897 | 252/18723 | 4.47e-03 | 3.56e-02 | 55 |
GO:00066501 | Colorectum | SER | glycerophospholipid metabolic process | 64/2897 | 306/18723 | 6.41e-03 | 4.60e-02 | 64 |
GO:00709972 | Colorectum | MSS | neuron death | 97/3467 | 361/18723 | 5.21e-05 | 9.31e-04 | 97 |
GO:00514022 | Colorectum | MSS | neuron apoptotic process | 66/3467 | 246/18723 | 7.94e-04 | 8.36e-03 | 66 |
GO:00709974 | Colorectum | FAP | neuron death | 81/2622 | 361/18723 | 8.35e-06 | 2.46e-04 | 81 |
GO:00514024 | Colorectum | FAP | neuron apoptotic process | 55/2622 | 246/18723 | 2.42e-04 | 3.37e-03 | 55 |
GO:0008654 | Colorectum | FAP | phospholipid biosynthetic process | 54/2622 | 253/18723 | 8.88e-04 | 9.08e-03 | 54 |
GO:00066502 | Colorectum | FAP | glycerophospholipid metabolic process | 62/2622 | 306/18723 | 1.54e-03 | 1.38e-02 | 62 |
GO:00066442 | Colorectum | FAP | phospholipid metabolic process | 74/2622 | 383/18723 | 2.24e-03 | 1.83e-02 | 74 |
GO:0046474 | Colorectum | FAP | glycerophospholipid biosynthetic process | 44/2622 | 211/18723 | 3.98e-03 | 2.76e-02 | 44 |
GO:00450172 | Colorectum | FAP | glycerolipid biosynthetic process | 50/2622 | 252/18723 | 6.32e-03 | 3.95e-02 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa005632 | Esophagus | ESCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 21/4205 | 26/8465 | 1.10e-03 | 3.42e-03 | 1.75e-03 | 21 |
hsa0056311 | Esophagus | ESCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 21/4205 | 26/8465 | 1.10e-03 | 3.42e-03 | 1.75e-03 | 21 |
hsa00563 | Liver | HCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 18/4020 | 26/8465 | 2.08e-02 | 4.81e-02 | 2.68e-02 | 18 |
hsa005631 | Liver | HCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 18/4020 | 26/8465 | 2.08e-02 | 4.81e-02 | 2.68e-02 | 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PIGT | SNV | Missense_Mutation | novel | c.641G>T | p.Ser214Ile | p.S214I | Q969N2 | protein_coding | deleterious(0.03) | probably_damaging(0.915) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
PIGT | insertion | Frame_Shift_Ins | rs749895437 | c.1036_1037insC | p.Val349SerfsTer99 | p.V349Sfs*99 | Q969N2 | protein_coding | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PIGT | SNV | Missense_Mutation | c.831N>C | p.Glu277Asp | p.E277D | Q969N2 | protein_coding | tolerated(0.48) | benign(0.096) | TCGA-49-6743-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
PIGT | SNV | Missense_Mutation | novel | c.975G>A | p.Met325Ile | p.M325I | Q969N2 | protein_coding | tolerated(0.47) | benign(0.006) | TCGA-64-1681-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Targeted Molecular therapy | tarceva | PD |
PIGT | SNV | Missense_Mutation | novel | c.1601N>G | p.Thr534Ser | p.T534S | Q969N2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PIGT | SNV | Missense_Mutation | rs202220796 | c.836N>A | p.Arg279Gln | p.R279Q | Q969N2 | protein_coding | tolerated(0.11) | benign(0.207) | TCGA-93-A4JO-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PIGT | SNV | Missense_Mutation | rs767247379 | c.1721N>T | p.Gly574Val | p.G574V | Q969N2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.973) | TCGA-97-A4M7-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PIGT | SNV | Missense_Mutation | novel | c.1094A>C | p.Lys365Thr | p.K365T | Q969N2 | protein_coding | tolerated(0.93) | benign(0.001) | TCGA-NC-A5HM-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PIGT | insertion | Frame_Shift_Ins | novel | c.564dupC | p.Trp189LeufsTer8 | p.W189Lfs*8 | Q969N2 | protein_coding | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | ||
PIGT | insertion | Frame_Shift_Ins | novel | c.245dupT | p.Arg83ThrfsTer40 | p.R83Tfs*40 | Q969N2 | protein_coding | TCGA-95-A4VN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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