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Gene: PDLIM2 |
Gene summary for PDLIM2 |
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Gene information | Species | Human | Gene symbol | PDLIM2 | Gene ID | 64236 |
Gene name | PDZ and LIM domain 2 | |
Gene Alias | MYSTIQUE | |
Cytomap | 8p21.3 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q96JY6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64236 | PDLIM2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.60e-12 | 4.02e-01 | -0.1808 |
64236 | PDLIM2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.45e-06 | 1.78e-01 | -0.1954 |
64236 | PDLIM2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.50e-04 | 5.07e-01 | -0.2196 |
64236 | PDLIM2 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.56e-07 | 1.59e-01 | -0.1464 |
64236 | PDLIM2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.08e-04 | 1.43e-01 | -0.059 |
64236 | PDLIM2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.72e-05 | 3.79e-01 | -0.1706 |
64236 | PDLIM2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.92e-03 | 1.99e-01 | 0.2585 |
64236 | PDLIM2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.04e-05 | 1.21e-01 | 0.3005 |
64236 | PDLIM2 | LZE4T | Human | Esophagus | ESCC | 9.50e-16 | 4.19e-01 | 0.0811 |
64236 | PDLIM2 | LZE24T | Human | Esophagus | ESCC | 2.26e-11 | 4.63e-01 | 0.0596 |
64236 | PDLIM2 | LZE21T | Human | Esophagus | ESCC | 7.54e-07 | 2.12e-01 | 0.0655 |
64236 | PDLIM2 | P2T-E | Human | Esophagus | ESCC | 7.68e-10 | 1.00e-01 | 0.1177 |
64236 | PDLIM2 | P4T-E | Human | Esophagus | ESCC | 1.44e-17 | 4.92e-01 | 0.1323 |
64236 | PDLIM2 | P5T-E | Human | Esophagus | ESCC | 1.17e-10 | 2.96e-01 | 0.1327 |
64236 | PDLIM2 | P8T-E | Human | Esophagus | ESCC | 7.78e-09 | 2.91e-01 | 0.0889 |
64236 | PDLIM2 | P9T-E | Human | Esophagus | ESCC | 1.92e-06 | 2.08e-01 | 0.1131 |
64236 | PDLIM2 | P10T-E | Human | Esophagus | ESCC | 8.51e-57 | 1.10e+00 | 0.116 |
64236 | PDLIM2 | P11T-E | Human | Esophagus | ESCC | 1.33e-06 | 1.64e-01 | 0.1426 |
64236 | PDLIM2 | P12T-E | Human | Esophagus | ESCC | 1.59e-27 | 6.32e-01 | 0.1122 |
64236 | PDLIM2 | P15T-E | Human | Esophagus | ESCC | 3.08e-10 | 3.22e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDLIM2 | SNV | Missense_Mutation | novel | c.1567N>T | p.Ala523Ser | p.A523S | Q96JY6 | protein_coding | tolerated(0.27) | benign(0.041) | TCGA-MP-A4T2-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PDLIM2 | SNV | Missense_Mutation | c.1066N>A | p.Gly356Ser | p.G356S | Q96JY6 | protein_coding | deleterious(0.04) | possibly_damaging(0.646) | TCGA-BA-4078-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PDLIM2 | SNV | Missense_Mutation | rs772195717 | c.881G>A | p.Arg294Gln | p.R294Q | Q96JY6 | protein_coding | tolerated(0.31) | probably_damaging(0.987) | TCGA-CV-5973-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PDLIM2 | SNV | Missense_Mutation | rs368145484 | c.1520N>T | p.Thr507Met | p.T507M | Q96JY6 | protein_coding | deleterious(0.03) | benign(0.309) | TCGA-TN-A7HI-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PDLIM2 | SNV | Missense_Mutation | c.1205N>A | p.Ser402Asn | p.S402N | Q96JY6 | protein_coding | tolerated(0.13) | benign(0.051) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PDLIM2 | SNV | Missense_Mutation | c.1066N>A | p.Gly356Ser | p.G356S | Q96JY6 | protein_coding | deleterious(0.04) | possibly_damaging(0.646) | TCGA-D7-6528-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PDLIM2 | SNV | Missense_Mutation | novel | c.1216N>A | p.Gln406Lys | p.Q406K | Q96JY6 | protein_coding | deleterious(0.02) | probably_damaging(0.954) | TCGA-HU-8238-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | didox | SD |
PDLIM2 | SNV | Missense_Mutation | rs773451486 | c.917N>A | p.Ser306Asn | p.S306N | Q96JY6 | protein_coding | tolerated(0.29) | benign(0.051) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD |
PDLIM2 | SNV | Missense_Mutation | rs544059643 | c.920N>T | p.Ala307Val | p.A307V | Q96JY6 | protein_coding | tolerated(0.08) | benign(0.362) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
PDLIM2 | SNV | Missense_Mutation | rs748585448 | c.979C>T | p.Arg327Trp | p.R327W | Q96JY6 | protein_coding | deleterious(0.02) | probably_damaging(0.99) | TCGA-VQ-A8PF-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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