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Gene: PDHX |
Gene summary for PDHX |
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Gene information | Species | Human | Gene symbol | PDHX | Gene ID | 8050 |
Gene name | pyruvate dehydrogenase complex component X | |
Gene Alias | DLDBP | |
Cytomap | 11p13 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | O00330 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8050 | PDHX | LZE4T | Human | Esophagus | ESCC | 5.91e-10 | 3.97e-01 | 0.0811 |
8050 | PDHX | LZE7T | Human | Esophagus | ESCC | 2.31e-09 | 4.62e-01 | 0.0667 |
8050 | PDHX | LZE22T | Human | Esophagus | ESCC | 5.55e-03 | 3.13e-01 | 0.068 |
8050 | PDHX | LZE24T | Human | Esophagus | ESCC | 2.65e-14 | 3.54e-01 | 0.0596 |
8050 | PDHX | P1T-E | Human | Esophagus | ESCC | 7.55e-03 | 2.63e-01 | 0.0875 |
8050 | PDHX | P2T-E | Human | Esophagus | ESCC | 5.66e-23 | 2.52e-01 | 0.1177 |
8050 | PDHX | P4T-E | Human | Esophagus | ESCC | 1.21e-06 | 2.44e-01 | 0.1323 |
8050 | PDHX | P5T-E | Human | Esophagus | ESCC | 1.79e-08 | 2.18e-02 | 0.1327 |
8050 | PDHX | P8T-E | Human | Esophagus | ESCC | 3.71e-26 | 3.25e-01 | 0.0889 |
8050 | PDHX | P9T-E | Human | Esophagus | ESCC | 8.25e-12 | 2.25e-01 | 0.1131 |
8050 | PDHX | P10T-E | Human | Esophagus | ESCC | 6.63e-20 | 1.82e-01 | 0.116 |
8050 | PDHX | P11T-E | Human | Esophagus | ESCC | 4.24e-04 | 3.76e-01 | 0.1426 |
8050 | PDHX | P12T-E | Human | Esophagus | ESCC | 2.20e-22 | 3.04e-01 | 0.1122 |
8050 | PDHX | P15T-E | Human | Esophagus | ESCC | 3.72e-18 | 3.70e-01 | 0.1149 |
8050 | PDHX | P16T-E | Human | Esophagus | ESCC | 3.35e-21 | 2.26e-01 | 0.1153 |
8050 | PDHX | P20T-E | Human | Esophagus | ESCC | 1.15e-09 | 2.45e-01 | 0.1124 |
8050 | PDHX | P21T-E | Human | Esophagus | ESCC | 3.85e-11 | 2.11e-01 | 0.1617 |
8050 | PDHX | P22T-E | Human | Esophagus | ESCC | 3.04e-38 | 6.36e-01 | 0.1236 |
8050 | PDHX | P23T-E | Human | Esophagus | ESCC | 5.88e-06 | 1.68e-01 | 0.108 |
8050 | PDHX | P24T-E | Human | Esophagus | ESCC | 4.44e-19 | 1.89e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0019693111 | Esophagus | ESCC | ribose phosphate metabolic process | 234/8552 | 396/18723 | 4.24e-08 | 7.76e-07 | 234 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:0009259111 | Esophagus | ESCC | ribonucleotide metabolic process | 224/8552 | 385/18723 | 4.41e-07 | 6.00e-06 | 224 |
GO:0072521111 | Esophagus | ESCC | purine-containing compound metabolic process | 238/8552 | 416/18723 | 1.20e-06 | 1.49e-05 | 238 |
GO:0009150111 | Esophagus | ESCC | purine ribonucleotide metabolic process | 213/8552 | 368/18723 | 1.40e-06 | 1.69e-05 | 213 |
GO:0046390110 | Esophagus | ESCC | ribose phosphate biosynthetic process | 119/8552 | 190/18723 | 1.73e-06 | 2.06e-05 | 119 |
GO:00442725 | Esophagus | ESCC | sulfur compound biosynthetic process | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
GO:0006163111 | Esophagus | ESCC | purine nucleotide metabolic process | 226/8552 | 396/18723 | 2.81e-06 | 3.21e-05 | 226 |
GO:000916516 | Esophagus | ESCC | nucleotide biosynthetic process | 150/8552 | 254/18723 | 1.12e-05 | 1.06e-04 | 150 |
GO:0009260110 | Esophagus | ESCC | ribonucleotide biosynthetic process | 112/8552 | 182/18723 | 1.12e-05 | 1.06e-04 | 112 |
GO:190129316 | Esophagus | ESCC | nucleoside phosphate biosynthetic process | 151/8552 | 256/18723 | 1.15e-05 | 1.08e-04 | 151 |
GO:00338664 | Esophagus | ESCC | nucleoside bisphosphate biosynthetic process | 44/8552 | 60/18723 | 1.25e-05 | 1.15e-04 | 44 |
GO:00340304 | Esophagus | ESCC | ribonucleoside bisphosphate biosynthetic process | 44/8552 | 60/18723 | 1.25e-05 | 1.15e-04 | 44 |
GO:00340334 | Esophagus | ESCC | purine nucleoside bisphosphate biosynthetic process | 44/8552 | 60/18723 | 1.25e-05 | 1.15e-04 | 44 |
GO:007252217 | Esophagus | ESCC | purine-containing compound biosynthetic process | 120/8552 | 200/18723 | 3.02e-05 | 2.51e-04 | 120 |
GO:0009152110 | Esophagus | ESCC | purine ribonucleotide biosynthetic process | 103/8552 | 169/18723 | 4.40e-05 | 3.51e-04 | 103 |
GO:000616417 | Esophagus | ESCC | purine nucleotide biosynthetic process | 113/8552 | 191/18723 | 1.16e-04 | 8.04e-04 | 113 |
GO:00353844 | Esophagus | ESCC | thioester biosynthetic process | 32/8552 | 45/18723 | 4.87e-04 | 2.70e-03 | 32 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDHX | SNV | Missense_Mutation | c.646N>A | p.Ala216Thr | p.A216T | O00330 | protein_coding | deleterious(0.04) | benign(0.375) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PDHX | SNV | Missense_Mutation | rs775413853 | c.1390C>T | p.Arg464Cys | p.R464C | O00330 | protein_coding | tolerated(0.15) | benign(0.042) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
PDHX | SNV | Missense_Mutation | c.1113N>C | p.Lys371Asn | p.K371N | O00330 | protein_coding | tolerated(0.16) | benign(0.043) | TCGA-G3-A3CK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PDHX | SNV | Missense_Mutation | novel | c.785N>A | p.Pro262Gln | p.P262Q | O00330 | protein_coding | deleterious(0.02) | benign(0.066) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD |
PDHX | SNV | Missense_Mutation | c.440N>C | p.Val147Ala | p.V147A | O00330 | protein_coding | tolerated(0.82) | benign(0) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PDHX | SNV | Missense_Mutation | c.772C>T | p.Pro258Ser | p.P258S | O00330 | protein_coding | deleterious(0.05) | benign(0.017) | TCGA-21-1070-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PDHX | SNV | Missense_Mutation | novel | c.508N>T | p.Pro170Ser | p.P170S | O00330 | protein_coding | tolerated(0.17) | benign(0.001) | TCGA-56-8305-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDHX | deletion | In_Frame_Del | novel | c.136_144delNNNNNNNNN | p.Phe46_Ser48del | p.F46_S48del | O00330 | protein_coding | TCGA-85-A4QR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
PDHX | SNV | Missense_Mutation | c.1427N>T | p.Arg476Leu | p.R476L | O00330 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | |
PDHX | SNV | Missense_Mutation | novel | c.409N>C | p.Asp137His | p.D137H | O00330 | protein_coding | deleterious(0) | possibly_damaging(0.814) | TCGA-CQ-6221-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8050 | PDHX | KINASE | AUTOANTIGEN | 8464876 | ||
8050 | PDHX | KINASE | ANTIOXIDANT | 14607783 |
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