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Gene: PDE11A |
Gene summary for PDE11A |
Gene summary. |
Gene information | Species | Human | Gene symbol | PDE11A | Gene ID | 50940 |
Gene name | phosphodiesterase 11A | |
Gene Alias | PPNAD2 | |
Cytomap | 2q31.2 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9HCR9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50940 | PDE11A | S41 | Human | Liver | Cirrhotic | 6.50e-04 | 3.03e-01 | -0.0343 |
50940 | PDE11A | HCC1_Meng | Human | Liver | HCC | 5.42e-05 | -1.81e-03 | 0.0246 |
50940 | PDE11A | HCC2_Meng | Human | Liver | HCC | 3.32e-03 | 3.68e-02 | 0.0107 |
50940 | PDE11A | HCC1 | Human | Liver | HCC | 3.64e-20 | 1.99e+00 | 0.5336 |
50940 | PDE11A | HCC2 | Human | Liver | HCC | 9.17e-41 | 2.16e+00 | 0.5341 |
50940 | PDE11A | HCC5 | Human | Liver | HCC | 1.62e-58 | 2.61e+00 | 0.4932 |
50940 | PDE11A | S015 | Human | Liver | HCC | 1.62e-08 | 3.17e-01 | 0.2375 |
50940 | PDE11A | S016 | Human | Liver | HCC | 5.33e-06 | 1.59e-01 | 0.2243 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDE11A | SNV | Missense_Mutation | c.2256C>G | p.Ile752Met | p.I752M | Q9HCR9 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-F5-6465-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PDE11A | insertion | In_Frame_Ins | novel | c.962_963insTCTTACTTTTTC | p.Lys321delinsAsnLeuThrPheSer | p.K321delinsNLTFS | Q9HCR9 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PDE11A | deletion | Frame_Shift_Del | c.498delN | p.Thr167ProfsTer14 | p.T167Pfs*14 | Q9HCR9 | protein_coding | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
PDE11A | SNV | Missense_Mutation | novel | c.2568N>G | p.Ile856Met | p.I856M | Q9HCR9 | protein_coding | tolerated(0.35) | benign(0.119) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDE11A | SNV | Missense_Mutation | rs779083062 | c.1237N>T | p.Arg413Trp | p.R413W | Q9HCR9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PDE11A | SNV | Missense_Mutation | c.771N>A | p.Phe257Leu | p.F257L | Q9HCR9 | protein_coding | tolerated(1) | benign(0.021) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PDE11A | SNV | Missense_Mutation | novel | c.2696C>A | p.Ala899Asp | p.A899D | Q9HCR9 | protein_coding | tolerated(0.64) | benign(0.001) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDE11A | SNV | Missense_Mutation | c.1460N>G | p.Asn487Ser | p.N487S | Q9HCR9 | protein_coding | deleterious(0) | possibly_damaging(0.559) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
PDE11A | SNV | Missense_Mutation | novel | c.82N>T | p.Arg28Trp | p.R28W | Q9HCR9 | protein_coding | deleterious(0) | possibly_damaging(0.446) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDE11A | SNV | Missense_Mutation | c.771N>A | p.Phe257Leu | p.F257L | Q9HCR9 | protein_coding | tolerated(1) | benign(0.021) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
50940 | PDE11A | DRUGGABLE GENOME, ENZYME | inhibitor | 178103173 | ||
50940 | PDE11A | DRUGGABLE GENOME, ENZYME | inhibitor | 178103872 | TADALAFIL |
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