![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PCSK2 |
Gene summary for PCSK2 |
![]() |
Gene information | Species | Human | Gene symbol | PCSK2 | Gene ID | 5126 |
Gene name | proprotein convertase subtilisin/kexin type 2 | |
Gene Alias | NEC 2 | |
Cytomap | 20p12.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P16519 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5126 | PCSK2 | HTA12-15-2 | Human | Pancreas | PDAC | 2.17e-05 | 5.79e-01 | 0.2315 |
5126 | PCSK2 | HTA12-23-1 | Human | Pancreas | PDAC | 1.51e-15 | 1.19e+00 | 0.3405 |
5126 | PCSK2 | HTA12-25-1 | Human | Pancreas | PDAC | 5.67e-17 | 1.21e+00 | 0.313 |
5126 | PCSK2 | HTA12-26-1 | Human | Pancreas | PDAC | 2.74e-44 | 1.51e+00 | 0.3728 |
5126 | PCSK2 | HTA12-29-1 | Human | Pancreas | PDAC | 1.85e-87 | 1.61e+00 | 0.3722 |
5126 | PCSK2 | HTA12-30-1 | Human | Pancreas | PDAC | 3.25e-02 | 8.60e-01 | 0.3671 |
5126 | PCSK2 | HTA12-32-1 | Human | Pancreas | PDAC | 4.48e-04 | 1.23e+00 | 0.3624 |
5126 | PCSK2 | HTA12-9-3 | Human | Pancreas | PDAC | 1.52e-08 | 1.09e+00 | 0.2045 |
5126 | PCSK2 | PTCwithHT_8 | Human | Thyroid | HT | 1.97e-20 | 8.71e-01 | 0.0351 |
5126 | PCSK2 | PTCwithoutHT_2 | Human | Thyroid | PTC | 2.39e-04 | 4.34e-01 | 0.0419 |
5126 | PCSK2 | PTCwithoutHT_4_2 | Human | Thyroid | PTC | 9.14e-06 | 8.42e-01 | 0.0455 |
5126 | PCSK2 | male-WTA | Human | Thyroid | PTC | 1.46e-26 | 5.24e-01 | 0.1037 |
5126 | PCSK2 | female-WTA | Human | Thyroid | PTC | 5.13e-22 | 1.03e+00 | 0.0726 |
5126 | PCSK2 | PTC01 | Human | Thyroid | PTC | 6.01e-29 | 1.52e+00 | 0.1899 |
5126 | PCSK2 | PTC04 | Human | Thyroid | PTC | 3.30e-76 | 2.34e+00 | 0.1927 |
5126 | PCSK2 | PTC05 | Human | Thyroid | PTC | 1.36e-13 | 1.04e+00 | 0.2065 |
5126 | PCSK2 | PTC06 | Human | Thyroid | PTC | 7.16e-24 | 2.00e+00 | 0.2057 |
5126 | PCSK2 | PTC07 | Human | Thyroid | PTC | 2.11e-46 | 1.56e+00 | 0.2044 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005160420 | Thyroid | PTC | protein maturation | 132/5968 | 294/18723 | 1.71e-06 | 2.39e-05 | 132 |
GO:00164859 | Thyroid | PTC | protein processing | 95/5968 | 225/18723 | 6.60e-04 | 4.15e-03 | 95 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCSK2 | SNV | Missense_Mutation | novel | c.500N>G | p.Asp167Gly | p.D167G | P16519 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCSK2 | SNV | Missense_Mutation | novel | c.1237N>T | p.Thr413Ser | p.T413S | P16519 | protein_coding | tolerated(0.07) | benign(0.014) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCSK2 | SNV | Missense_Mutation | c.650C>A | p.Ser217Tyr | p.S217Y | P16519 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCSK2 | SNV | Missense_Mutation | c.1499T>C | p.Phe500Ser | p.F500S | P16519 | protein_coding | tolerated(0.41) | benign(0.001) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCSK2 | SNV | Missense_Mutation | rs752788983 | c.152N>T | p.Ala51Val | p.A51V | P16519 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-D1-A160-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCSK2 | SNV | Missense_Mutation | novel | c.281N>T | p.Arg94Met | p.R94M | P16519 | protein_coding | tolerated(0.1) | benign(0.007) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PCSK2 | SNV | Missense_Mutation | novel | c.638N>T | p.Ala213Val | p.A213V | P16519 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PCSK2 | SNV | Missense_Mutation | rs550032490 | c.1291N>T | p.Arg431Cys | p.R431C | P16519 | protein_coding | tolerated(0.14) | benign(0.087) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PCSK2 | SNV | Missense_Mutation | rs754916065 | c.1535N>T | p.Thr512Met | p.T512M | P16519 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-EO-A3AZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCSK2 | SNV | Missense_Mutation | c.856C>A | p.Leu286Met | p.L286M | P16519 | protein_coding | tolerated(0.7) | benign(0.14) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5126 | PCSK2 | PROTEASE, ENZYME, DRUGGABLE GENOME | inhibitor | 252166858 |
Page: 1 |