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Gene: PCM1 |
Gene summary for PCM1 |
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Gene information | Species | Human | Gene symbol | PCM1 | Gene ID | 5108 |
Gene name | pericentriolar material 1 | |
Gene Alias | PTC4 | |
Cytomap | 8p22 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | B9EIS5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5108 | PCM1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.29e-21 | -5.64e-01 | 0.0155 |
5108 | PCM1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.31e-06 | -4.64e-01 | -0.1808 |
5108 | PCM1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.10e-02 | -6.85e-01 | -0.2196 |
5108 | PCM1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.61e-09 | -4.79e-01 | -0.1207 |
5108 | PCM1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.46e-03 | -3.87e-01 | -0.1526 |
5108 | PCM1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.36e-03 | -3.16e-01 | -0.1464 |
5108 | PCM1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.89e-02 | -2.80e-01 | -0.1001 |
5108 | PCM1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.01e-03 | -3.63e-01 | -0.059 |
5108 | PCM1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.15e-04 | -6.17e-01 | -0.2061 |
5108 | PCM1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.23e-03 | -7.35e-01 | -0.1462 |
5108 | PCM1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.27e-03 | -4.93e-01 | -0.0179 |
5108 | PCM1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.84e-06 | -3.92e-01 | 0.096 |
5108 | PCM1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.55e-02 | -3.90e-01 | 0.0338 |
5108 | PCM1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.90e-08 | -3.42e-01 | 0.0674 |
5108 | PCM1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.92e-19 | -5.83e-01 | 0.3859 |
5108 | PCM1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.66e-12 | -4.21e-01 | 0.3005 |
5108 | PCM1 | A015-C-203 | Human | Colorectum | FAP | 1.90e-23 | -6.10e-02 | -0.1294 |
5108 | PCM1 | A014-C-040 | Human | Colorectum | FAP | 3.97e-03 | -7.61e-02 | -0.1184 |
5108 | PCM1 | A002-C-201 | Human | Colorectum | FAP | 4.03e-11 | -1.13e-01 | 0.0324 |
5108 | PCM1 | A001-C-119 | Human | Colorectum | FAP | 5.81e-05 | 9.19e-02 | -0.1557 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:0090316 | Colorectum | AD | positive regulation of intracellular protein transport | 62/3918 | 160/18723 | 1.82e-07 | 7.79e-06 | 62 |
GO:0032388 | Colorectum | AD | positive regulation of intracellular transport | 74/3918 | 202/18723 | 1.83e-07 | 7.80e-06 | 74 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0033157 | Colorectum | AD | regulation of intracellular protein transport | 80/3918 | 229/18723 | 5.81e-07 | 2.09e-05 | 80 |
GO:0071539 | Colorectum | AD | protein localization to centrosome | 16/3918 | 33/18723 | 3.86e-04 | 4.41e-03 | 16 |
GO:0030705 | Colorectum | AD | cytoskeleton-dependent intracellular transport | 60/3918 | 195/18723 | 7.56e-04 | 7.59e-03 | 60 |
GO:1905508 | Colorectum | AD | protein localization to microtubule organizing center | 16/3918 | 35/18723 | 8.76e-04 | 8.51e-03 | 16 |
GO:0050767 | Colorectum | AD | regulation of neurogenesis | 99/3918 | 364/18723 | 2.35e-03 | 1.82e-02 | 99 |
GO:0007097 | Colorectum | AD | nuclear migration | 10/3918 | 20/18723 | 3.67e-03 | 2.60e-02 | 10 |
GO:0051647 | Colorectum | AD | nucleus localization | 11/3918 | 24/18723 | 5.43e-03 | 3.55e-02 | 11 |
GO:19049511 | Colorectum | SER | positive regulation of establishment of protein localization | 91/2897 | 319/18723 | 1.69e-09 | 1.68e-07 | 91 |
GO:00512221 | Colorectum | SER | positive regulation of protein transport | 85/2897 | 303/18723 | 1.36e-08 | 1.05e-06 | 85 |
GO:00331571 | Colorectum | SER | regulation of intracellular protein transport | 68/2897 | 229/18723 | 3.41e-08 | 2.30e-06 | 68 |
GO:00903161 | Colorectum | SER | positive regulation of intracellular protein transport | 52/2897 | 160/18723 | 5.64e-08 | 3.72e-06 | 52 |
GO:00516561 | Colorectum | SER | establishment of organelle localization | 100/2897 | 390/18723 | 1.11e-07 | 6.79e-06 | 100 |
GO:00323861 | Colorectum | SER | regulation of intracellular transport | 89/2897 | 337/18723 | 1.34e-07 | 7.96e-06 | 89 |
GO:00323881 | Colorectum | SER | positive regulation of intracellular transport | 59/2897 | 202/18723 | 4.98e-07 | 2.48e-05 | 59 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCM1 | SNV | Missense_Mutation | c.3021N>T | p.Lys1007Asn | p.K1007N | Q15154 | protein_coding | deleterious(0) | possibly_damaging(0.79) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PCM1 | SNV | Missense_Mutation | c.5587N>T | p.Asp1863Tyr | p.D1863Y | Q15154 | protein_coding | deleterious(0) | probably_damaging(0.919) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PCM1 | SNV | Missense_Mutation | rs377370109 | c.1811G>A | p.Arg604Gln | p.R604Q | Q15154 | protein_coding | tolerated(1) | possibly_damaging(0.483) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
PCM1 | SNV | Missense_Mutation | novel | c.3878A>C | p.Lys1293Thr | p.K1293T | Q15154 | protein_coding | tolerated(0.06) | possibly_damaging(0.695) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
PCM1 | SNV | Missense_Mutation | novel | c.141N>T | p.Lys47Asn | p.K47N | Q15154 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PCM1 | SNV | Missense_Mutation | novel | c.4552N>T | p.Asp1518Tyr | p.D1518Y | Q15154 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PCM1 | insertion | Nonsense_Mutation | novel | c.213_214insAAATAG | p.Gly71_Val72insLysTer | p.G71_V72insK* | Q15154 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PCM1 | insertion | Frame_Shift_Ins | novel | c.5919_5920insACAATATATTCAGAGGTATT | p.Ala1979ValfsTer10 | p.A1979Vfs*10 | Q15154 | protein_coding | TCGA-CA-5797-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
PCM1 | insertion | In_Frame_Ins | novel | c.5571_5572insGCCACTAGTAAAAGTAAGAAATCTAAG | p.Lys1861_Asn1862insSerLysLysSerLysAlaThrSerLys | p.K1861_N1862insSKKSKATSK | Q15154 | protein_coding | TCGA-F4-6809-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
PCM1 | SNV | Missense_Mutation | novel | c.46G>A | p.Asp16Asn | p.D16N | Q15154 | protein_coding | tolerated(0.09) | possibly_damaging(0.802) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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