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Gene: PCED1A |
Gene summary for PCED1A |
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Gene information | Species | Human | Gene symbol | PCED1A | Gene ID | 64773 |
Gene name | PC-esterase domain containing 1A | |
Gene Alias | C20orf81 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q9H1Q7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64773 | PCED1A | LZE24T | Human | Esophagus | ESCC | 4.55e-13 | 3.69e-01 | 0.0596 |
64773 | PCED1A | P1T-E | Human | Esophagus | ESCC | 3.76e-13 | 5.33e-01 | 0.0875 |
64773 | PCED1A | P2T-E | Human | Esophagus | ESCC | 5.11e-26 | 3.83e-01 | 0.1177 |
64773 | PCED1A | P4T-E | Human | Esophagus | ESCC | 5.91e-13 | 2.70e-01 | 0.1323 |
64773 | PCED1A | P5T-E | Human | Esophagus | ESCC | 1.48e-02 | 7.45e-02 | 0.1327 |
64773 | PCED1A | P8T-E | Human | Esophagus | ESCC | 7.79e-13 | 1.18e-01 | 0.0889 |
64773 | PCED1A | P9T-E | Human | Esophagus | ESCC | 1.01e-14 | 3.67e-01 | 0.1131 |
64773 | PCED1A | P10T-E | Human | Esophagus | ESCC | 3.15e-15 | 2.92e-01 | 0.116 |
64773 | PCED1A | P11T-E | Human | Esophagus | ESCC | 2.52e-10 | 4.13e-01 | 0.1426 |
64773 | PCED1A | P12T-E | Human | Esophagus | ESCC | 4.25e-21 | 3.64e-01 | 0.1122 |
64773 | PCED1A | P15T-E | Human | Esophagus | ESCC | 1.12e-07 | 1.40e-01 | 0.1149 |
64773 | PCED1A | P16T-E | Human | Esophagus | ESCC | 8.39e-24 | 5.06e-01 | 0.1153 |
64773 | PCED1A | P17T-E | Human | Esophagus | ESCC | 2.40e-15 | 4.83e-01 | 0.1278 |
64773 | PCED1A | P19T-E | Human | Esophagus | ESCC | 1.59e-07 | 3.23e-01 | 0.1662 |
64773 | PCED1A | P20T-E | Human | Esophagus | ESCC | 1.05e-19 | 3.91e-01 | 0.1124 |
64773 | PCED1A | P21T-E | Human | Esophagus | ESCC | 3.85e-12 | 2.71e-01 | 0.1617 |
64773 | PCED1A | P22T-E | Human | Esophagus | ESCC | 1.06e-19 | 2.35e-01 | 0.1236 |
64773 | PCED1A | P23T-E | Human | Esophagus | ESCC | 1.87e-13 | 3.67e-01 | 0.108 |
64773 | PCED1A | P24T-E | Human | Esophagus | ESCC | 3.94e-10 | 1.90e-01 | 0.1287 |
64773 | PCED1A | P26T-E | Human | Esophagus | ESCC | 5.27e-53 | 1.03e+00 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCED1A | SNV | Missense_Mutation | novel | c.559N>T | p.Gly187Trp | p.G187W | Q9H1Q7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-6980-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PCED1A | SNV | Missense_Mutation | c.1283N>T | p.Arg428Leu | p.R428L | Q9H1Q7 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.987) | TCGA-78-7154-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PCED1A | SNV | Missense_Mutation | c.839N>T | p.Pro280Leu | p.P280L | Q9H1Q7 | protein_coding | tolerated(0.52) | benign(0.007) | TCGA-60-2712-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCED1A | SNV | Missense_Mutation | novel | c.343C>T | p.Arg115Cys | p.R115C | Q9H1Q7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-H7-8501-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | CR |
PCED1A | SNV | Missense_Mutation | novel | c.17N>T | p.Ser6Leu | p.S6L | Q9H1Q7 | protein_coding | deleterious_low_confidence(0.02) | benign(0.006) | TCGA-KC-A4BR-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Hormone Therapy | lupron | CR |
PCED1A | SNV | Missense_Mutation | rs200943983 | c.706N>T | p.Arg236Trp | p.R236W | Q9H1Q7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PCED1A | SNV | Missense_Mutation | rs773982133 | c.68C>T | p.Ala23Val | p.A23V | Q9H1Q7 | protein_coding | deleterious(0.01) | probably_damaging(0.936) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
PCED1A | SNV | Missense_Mutation | rs771637059 | c.619N>T | p.Arg207Trp | p.R207W | Q9H1Q7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCED1A | SNV | Missense_Mutation | c.799N>A | p.Asp267Asn | p.D267N | Q9H1Q7 | protein_coding | deleterious(0.02) | benign(0.409) | TCGA-BR-6457-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Ancillary | leucovorin | CR | |
PCED1A | SNV | Missense_Mutation | rs773739970 | c.731G>A | p.Arg244Gln | p.R244Q | Q9H1Q7 | protein_coding | tolerated(0.17) | possibly_damaging(0.661) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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