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Gene: PCDH9 |
Gene summary for PCDH9 |
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Gene information | Species | Human | Gene symbol | PCDH9 | Gene ID | 5101 |
Gene name | protocadherin 9 | |
Gene Alias | PCDH9 | |
Cytomap | 13q21.32 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | B7ZM79 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5101 | PCDH9 | HTA12-23-1 | Human | Pancreas | PDAC | 1.55e-03 | 9.10e-01 | 0.3405 |
5101 | PCDH9 | HTA12-29-1 | Human | Pancreas | PDAC | 1.10e-08 | 5.46e-01 | 0.3722 |
5101 | PCDH9 | male-WTA | Human | Thyroid | PTC | 8.05e-15 | 7.50e-02 | 0.1037 |
5101 | PCDH9 | PTC06 | Human | Thyroid | PTC | 5.27e-09 | 4.15e-01 | 0.2057 |
5101 | PCDH9 | PTC07 | Human | Thyroid | PTC | 3.25e-25 | 6.34e-01 | 0.2044 |
5101 | PCDH9 | ATC11 | Human | Thyroid | ATC | 4.59e-05 | 6.90e-01 | 0.3386 |
5101 | PCDH9 | ATC2 | Human | Thyroid | ATC | 2.83e-13 | 1.13e+00 | 0.34 |
5101 | PCDH9 | ATC3 | Human | Thyroid | ATC | 1.08e-11 | 8.83e-01 | 0.338 |
5101 | PCDH9 | ATC5 | Human | Thyroid | ATC | 8.59e-03 | -1.39e-02 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00309007 | Thyroid | PTC | forebrain development | 143/5968 | 379/18723 | 8.47e-03 | 3.56e-02 | 143 |
GO:003090015 | Thyroid | ATC | forebrain development | 164/6293 | 379/18723 | 4.85e-05 | 3.87e-04 | 164 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCDH9 | SNV | Missense_Mutation | c.2797N>G | p.Pro933Ala | p.P933A | Q9HC56 | protein_coding | deleterious(0.01) | possibly_damaging(0.874) | TCGA-AA-3831-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PCDH9 | SNV | Missense_Mutation | rs147427572 | c.2662N>A | p.Glu888Lys | p.E888K | Q9HC56 | protein_coding | tolerated(0.05) | probably_damaging(0.936) | TCGA-AA-3842-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD |
PCDH9 | SNV | Missense_Mutation | c.2147C>T | p.Thr716Ile | p.T716I | Q9HC56 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-AA-3939-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PCDH9 | SNV | Missense_Mutation | c.1057N>A | p.Asp353Asn | p.D353N | Q9HC56 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3956-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PCDH9 | SNV | Missense_Mutation | c.254N>G | p.Ile85Ser | p.I85S | Q9HC56 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCDH9 | SNV | Missense_Mutation | novel | c.3002N>A | p.Gly1001Asp | p.G1001D | Q9HC56 | protein_coding | tolerated(0.23) | possibly_damaging(0.904) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PCDH9 | SNV | Missense_Mutation | novel | c.2441N>T | p.Thr814Ile | p.T814I | Q9HC56 | protein_coding | tolerated(0.16) | benign(0.088) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PCDH9 | SNV | Missense_Mutation | c.3123N>C | p.Glu1041Asp | p.E1041D | Q9HC56 | protein_coding | tolerated(0.62) | benign(0.217) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PCDH9 | SNV | Missense_Mutation | c.3305G>T | p.Arg1102Met | p.R1102M | Q9HC56 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
PCDH9 | SNV | Missense_Mutation | novel | c.3053A>C | p.Lys1018Thr | p.K1018T | Q9HC56 | protein_coding | tolerated(0.49) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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