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Gene: PBX1 |
Gene summary for PBX1 |
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Gene information | Species | Human | Gene symbol | PBX1 | Gene ID | 5087 |
Gene name | PBX homeobox 1 | |
Gene Alias | CAKUHED | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A8K5V0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5087 | PBX1 | GSM4909281 | Human | Breast | IDC | 2.40e-04 | 2.61e-01 | 0.21 |
5087 | PBX1 | GSM4909285 | Human | Breast | IDC | 1.64e-04 | 1.89e-01 | 0.21 |
5087 | PBX1 | GSM4909286 | Human | Breast | IDC | 3.80e-05 | 2.45e-01 | 0.1081 |
5087 | PBX1 | GSM4909290 | Human | Breast | IDC | 2.00e-06 | 3.54e-01 | 0.2096 |
5087 | PBX1 | GSM4909291 | Human | Breast | IDC | 7.85e-27 | 7.88e-01 | 0.1753 |
5087 | PBX1 | GSM4909293 | Human | Breast | IDC | 1.41e-63 | 1.01e+00 | 0.1581 |
5087 | PBX1 | GSM4909297 | Human | Breast | IDC | 3.19e-10 | 3.07e-01 | 0.1517 |
5087 | PBX1 | GSM4909298 | Human | Breast | IDC | 1.15e-60 | 9.19e-01 | 0.1551 |
5087 | PBX1 | GSM4909301 | Human | Breast | IDC | 4.04e-17 | 5.74e-01 | 0.1577 |
5087 | PBX1 | GSM4909302 | Human | Breast | IDC | 1.81e-04 | 3.03e-01 | 0.1545 |
5087 | PBX1 | GSM4909303 | Human | Breast | IDC | 1.81e-03 | 4.42e-01 | 0.0438 |
5087 | PBX1 | GSM4909305 | Human | Breast | IDC | 1.32e-02 | 2.47e-01 | 0.0436 |
5087 | PBX1 | GSM4909306 | Human | Breast | IDC | 2.26e-16 | 5.99e-01 | 0.1564 |
5087 | PBX1 | GSM4909307 | Human | Breast | IDC | 1.76e-38 | 8.53e-01 | 0.1569 |
5087 | PBX1 | GSM4909308 | Human | Breast | IDC | 2.34e-63 | 9.63e-01 | 0.158 |
5087 | PBX1 | GSM4909309 | Human | Breast | IDC | 3.60e-06 | 3.63e-01 | 0.0483 |
5087 | PBX1 | GSM4909311 | Human | Breast | IDC | 7.25e-14 | 3.06e-02 | 0.1534 |
5087 | PBX1 | GSM4909312 | Human | Breast | IDC | 8.46e-43 | 8.14e-01 | 0.1552 |
5087 | PBX1 | GSM4909313 | Human | Breast | IDC | 1.84e-19 | 6.51e-01 | 0.0391 |
5087 | PBX1 | GSM4909317 | Human | Breast | IDC | 2.09e-45 | 9.58e-01 | 0.1355 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00487329 | Breast | Precancer | gland development | 49/1080 | 436/18723 | 6.11e-06 | 1.73e-04 | 49 |
GO:19031313 | Breast | Precancer | mononuclear cell differentiation | 43/1080 | 426/18723 | 2.61e-04 | 3.84e-03 | 43 |
GO:0048538 | Breast | Precancer | thymus development | 9/1080 | 45/18723 | 9.22e-04 | 1.05e-02 | 9 |
GO:0030098 | Breast | Precancer | lymphocyte differentiation | 36/1080 | 374/18723 | 1.85e-03 | 1.81e-02 | 36 |
GO:00605625 | Breast | Precancer | epithelial tube morphogenesis | 31/1080 | 325/18723 | 4.21e-03 | 3.31e-02 | 31 |
GO:00720735 | Breast | Precancer | kidney epithelium development | 16/1080 | 136/18723 | 5.21e-03 | 3.88e-02 | 16 |
GO:00016572 | Breast | Precancer | ureteric bud development | 12/1080 | 91/18723 | 5.97e-03 | 4.22e-02 | 12 |
GO:00720803 | Breast | Precancer | nephron tubule development | 12/1080 | 91/18723 | 5.97e-03 | 4.22e-02 | 12 |
GO:00721632 | Breast | Precancer | mesonephric epithelium development | 12/1080 | 92/18723 | 6.51e-03 | 4.51e-02 | 12 |
GO:00721642 | Breast | Precancer | mesonephric tubule development | 12/1080 | 92/18723 | 6.51e-03 | 4.51e-02 | 12 |
GO:0072078 | Breast | Precancer | nephron tubule morphogenesis | 10/1080 | 71/18723 | 7.33e-03 | 4.88e-02 | 10 |
GO:00015036 | Breast | Precancer | ossification | 36/1080 | 408/18723 | 7.53e-03 | 4.98e-02 | 36 |
GO:004873214 | Breast | IDC | gland development | 64/1434 | 436/18723 | 3.47e-07 | 1.74e-05 | 64 |
GO:006056212 | Breast | IDC | epithelial tube morphogenesis | 44/1434 | 325/18723 | 1.58e-04 | 2.73e-03 | 44 |
GO:00611383 | Breast | IDC | morphogenesis of a branching epithelium | 28/1434 | 182/18723 | 3.05e-04 | 4.60e-03 | 28 |
GO:00017635 | Breast | IDC | morphogenesis of a branching structure | 29/1434 | 196/18723 | 4.68e-04 | 6.26e-03 | 29 |
GO:000150311 | Breast | IDC | ossification | 50/1434 | 408/18723 | 6.51e-04 | 8.04e-03 | 50 |
GO:190313111 | Breast | IDC | mononuclear cell differentiation | 51/1434 | 426/18723 | 9.81e-04 | 1.11e-02 | 51 |
GO:00066944 | Breast | IDC | steroid biosynthetic process | 25/1434 | 173/18723 | 1.56e-03 | 1.56e-02 | 25 |
GO:00485381 | Breast | IDC | thymus development | 10/1434 | 45/18723 | 1.80e-03 | 1.74e-02 | 10 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05202 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa052021 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa052026 | Lung | IAC | Transcriptional misregulation in cancer | 40/1053 | 193/8465 | 6.90e-04 | 5.90e-03 | 3.92e-03 | 40 |
hsa0520211 | Lung | IAC | Transcriptional misregulation in cancer | 40/1053 | 193/8465 | 6.90e-04 | 5.90e-03 | 3.92e-03 | 40 |
hsa052022 | Lung | AIS | Transcriptional misregulation in cancer | 39/961 | 193/8465 | 2.15e-04 | 2.41e-03 | 1.54e-03 | 39 |
hsa052023 | Lung | AIS | Transcriptional misregulation in cancer | 39/961 | 193/8465 | 2.15e-04 | 2.41e-03 | 1.54e-03 | 39 |
hsa052024 | Lung | MIAC | Transcriptional misregulation in cancer | 22/507 | 193/8465 | 2.64e-03 | 2.26e-02 | 1.64e-02 | 22 |
hsa052025 | Lung | MIAC | Transcriptional misregulation in cancer | 22/507 | 193/8465 | 2.64e-03 | 2.26e-02 | 1.64e-02 | 22 |
hsa052027 | Prostate | BPH | Transcriptional misregulation in cancer | 53/1718 | 193/8465 | 9.56e-03 | 2.92e-02 | 1.81e-02 | 53 |
hsa0520212 | Prostate | BPH | Transcriptional misregulation in cancer | 53/1718 | 193/8465 | 9.56e-03 | 2.92e-02 | 1.81e-02 | 53 |
hsa0520221 | Prostate | Tumor | Transcriptional misregulation in cancer | 59/1791 | 193/8465 | 1.22e-03 | 5.26e-03 | 3.26e-03 | 59 |
hsa0520231 | Prostate | Tumor | Transcriptional misregulation in cancer | 59/1791 | 193/8465 | 1.22e-03 | 5.26e-03 | 3.26e-03 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PBX1 | SNV | Missense_Mutation | novel | c.1154N>A | p.Ser385Asn | p.S385N | P40424 | protein_coding | tolerated(0.31) | benign(0.003) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PBX1 | SNV | Missense_Mutation | c.953N>A | p.Ala318Asp | p.A318D | P40424 | protein_coding | tolerated(0.07) | benign(0.027) | TCGA-DD-A11A-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PBX1 | SNV | Missense_Mutation | rs769833066 | c.540N>T | p.Met180Ile | p.M180I | P40424 | protein_coding | tolerated(0.07) | benign(0.261) | TCGA-DD-A1EB-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PBX1 | SNV | Missense_Mutation | c.1081N>A | p.Ala361Thr | p.A361T | P40424 | protein_coding | tolerated(0.24) | benign(0.04) | TCGA-DD-A3A7-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Chemotherapy | unknown | PD | |
PBX1 | SNV | Missense_Mutation | novel | c.680N>A | p.Arg227His | p.R227H | P40424 | protein_coding | deleterious(0.01) | possibly_damaging(0.563) | TCGA-DD-AACB-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PBX1 | SNV | Missense_Mutation | c.520N>A | p.Glu174Lys | p.E174K | P40424 | protein_coding | deleterious(0.02) | possibly_damaging(0.655) | TCGA-DD-AACQ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
PBX1 | SNV | Missense_Mutation | c.544C>T | p.Leu182Phe | p.L182F | P40424 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-G3-A25S-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sunitinib | PD | |
PBX1 | SNV | Missense_Mutation | novel | c.1058N>G | p.Leu353Arg | p.L353R | P40424 | protein_coding | deleterious(0) | possibly_damaging(0.756) | TCGA-44-6145-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PBX1 | SNV | Missense_Mutation | novel | c.1028C>G | p.Ser343Cys | p.S343C | P40424 | protein_coding | deleterious(0.02) | possibly_damaging(0.88) | TCGA-64-5781-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PBX1 | SNV | Missense_Mutation | novel | c.940N>T | p.Thr314Ser | p.T314S | P40424 | protein_coding | tolerated(0.2) | benign(0.001) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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