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Gene: PAQR8 |
Gene summary for PAQR8 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PAQR8 | Gene ID | 85315 |
Gene name | progestin and adipoQ receptor family member 8 | |
Gene Alias | C6orf33 | |
Cytomap | 6p12.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B3KXW6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85315 | PAQR8 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.21e-13 | 2.65e-01 | 0.0155 |
85315 | PAQR8 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.83e-24 | 7.29e-01 | -0.1808 |
85315 | PAQR8 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-03 | 2.52e-01 | 0.0216 |
85315 | PAQR8 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.30e-28 | 8.90e-01 | -0.0811 |
85315 | PAQR8 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.43e-34 | 8.15e-01 | -0.1088 |
85315 | PAQR8 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.57e-51 | 1.03e+00 | -0.1954 |
85315 | PAQR8 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.44e-09 | 6.31e-01 | -0.2602 |
85315 | PAQR8 | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.76e-08 | 4.80e-01 | -0.2196 |
85315 | PAQR8 | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.49e-18 | 5.37e-01 | -0.1207 |
85315 | PAQR8 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.15e-23 | 7.05e-01 | -0.1526 |
85315 | PAQR8 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.23e-23 | 5.14e-01 | -0.1464 |
85315 | PAQR8 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.46e-16 | 3.30e-01 | -0.1001 |
85315 | PAQR8 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.85e-28 | 7.07e-01 | -0.059 |
85315 | PAQR8 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.31e-08 | 4.85e-01 | -0.1706 |
85315 | PAQR8 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.59e-17 | 7.47e-01 | -0.2061 |
85315 | PAQR8 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.84e-10 | 6.08e-01 | -0.1462 |
85315 | PAQR8 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.76e-07 | 2.75e-01 | -0.0842 |
85315 | PAQR8 | HTA11_9341_2000001011 | Human | Colorectum | SER | 5.61e-03 | 2.55e-01 | -0.00410000000000005 |
85315 | PAQR8 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.24e-02 | 1.98e-01 | -0.0179 |
85315 | PAQR8 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.21e-15 | 3.76e-01 | 0.096 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0071383 | Colorectum | AD | cellular response to steroid hormone stimulus | 73/3918 | 204/18723 | 6.31e-07 | 2.24e-05 | 73 |
GO:0043401 | Colorectum | AD | steroid hormone mediated signaling pathway | 51/3918 | 136/18723 | 6.52e-06 | 1.63e-04 | 51 |
GO:0048545 | Colorectum | AD | response to steroid hormone | 104/3918 | 339/18723 | 1.33e-05 | 2.90e-04 | 104 |
GO:0009755 | Colorectum | AD | hormone-mediated signaling pathway | 64/3918 | 190/18723 | 2.78e-05 | 5.24e-04 | 64 |
GO:00713831 | Colorectum | SER | cellular response to steroid hormone stimulus | 55/2897 | 204/18723 | 1.66e-05 | 5.05e-04 | 55 |
GO:00485451 | Colorectum | SER | response to steroid hormone | 80/2897 | 339/18723 | 5.15e-05 | 1.25e-03 | 80 |
GO:00434011 | Colorectum | SER | steroid hormone mediated signaling pathway | 38/2897 | 136/18723 | 1.42e-04 | 2.82e-03 | 38 |
GO:00097551 | Colorectum | SER | hormone-mediated signaling pathway | 49/2897 | 190/18723 | 1.54e-04 | 3.00e-03 | 49 |
GO:00713832 | Colorectum | MSS | cellular response to steroid hormone stimulus | 72/3467 | 204/18723 | 8.87e-09 | 5.43e-07 | 72 |
GO:00434012 | Colorectum | MSS | steroid hormone mediated signaling pathway | 51/3467 | 136/18723 | 1.43e-07 | 6.67e-06 | 51 |
GO:00485452 | Colorectum | MSS | response to steroid hormone | 101/3467 | 339/18723 | 2.60e-07 | 1.10e-05 | 101 |
GO:00097552 | Colorectum | MSS | hormone-mediated signaling pathway | 63/3467 | 190/18723 | 9.26e-07 | 3.23e-05 | 63 |
GO:00485453 | Colorectum | MSI-H | response to steroid hormone | 40/1319 | 339/18723 | 9.37e-04 | 1.64e-02 | 40 |
GO:00434013 | Colorectum | MSI-H | steroid hormone mediated signaling pathway | 19/1319 | 136/18723 | 3.19e-03 | 3.93e-02 | 19 |
GO:00097553 | Colorectum | MSI-H | hormone-mediated signaling pathway | 24/1319 | 190/18723 | 3.88e-03 | 4.51e-02 | 24 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAQR8 | SNV | Missense_Mutation | novel | c.667N>A | p.Leu223Ile | p.L223I | Q8TEZ7 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-66-2769-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
PAQR8 | SNV | Missense_Mutation | rs769096577 | c.1012N>A | p.Ala338Thr | p.A338T | Q8TEZ7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PAQR8 | SNV | Missense_Mutation | novel | c.692N>T | p.Arg231Leu | p.R231L | Q8TEZ7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PAQR8 | SNV | Missense_Mutation | c.976T>G | p.Ser326Ala | p.S326A | Q8TEZ7 | protein_coding | tolerated(0.76) | benign(0.102) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PAQR8 | SNV | Missense_Mutation | c.235N>A | p.Val79Ile | p.V79I | Q8TEZ7 | protein_coding | tolerated(0.15) | probably_damaging(0.927) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAQR8 | SNV | Missense_Mutation | c.301G>A | p.Ala101Thr | p.A101T | Q8TEZ7 | protein_coding | tolerated(0.13) | benign(0.102) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
PAQR8 | SNV | Missense_Mutation | c.23N>A | p.Arg8His | p.R8H | Q8TEZ7 | protein_coding | tolerated(0.05) | benign(0.01) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |
PAQR8 | SNV | Missense_Mutation | c.166N>T | p.Arg56Cys | p.R56C | Q8TEZ7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR | |
PAQR8 | SNV | Missense_Mutation | novel | c.743A>C | p.His248Pro | p.H248P | Q8TEZ7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PAQR8 | SNV | Missense_Mutation | novel | c.34C>A | p.Leu12Met | p.L12M | Q8TEZ7 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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