![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: P4HTM |
Gene summary for P4HTM |
![]() |
Gene information | Species | Human | Gene symbol | P4HTM | Gene ID | 54681 |
Gene name | prolyl 4-hydroxylase, transmembrane | |
Gene Alias | EGLN4 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0002262 | UniProtAcc | Q9NXG6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54681 | P4HTM | LZE20T | Human | Esophagus | ESCC | 1.46e-02 | 1.79e-01 | 0.0662 |
54681 | P4HTM | LZE22T | Human | Esophagus | ESCC | 1.24e-03 | 3.06e-01 | 0.068 |
54681 | P4HTM | LZE24T | Human | Esophagus | ESCC | 4.64e-15 | 4.55e-01 | 0.0596 |
54681 | P4HTM | P1T-E | Human | Esophagus | ESCC | 9.04e-07 | 3.36e-01 | 0.0875 |
54681 | P4HTM | P2T-E | Human | Esophagus | ESCC | 3.97e-06 | 9.48e-02 | 0.1177 |
54681 | P4HTM | P4T-E | Human | Esophagus | ESCC | 5.59e-26 | 4.08e-01 | 0.1323 |
54681 | P4HTM | P5T-E | Human | Esophagus | ESCC | 2.27e-08 | 7.42e-02 | 0.1327 |
54681 | P4HTM | P8T-E | Human | Esophagus | ESCC | 4.69e-34 | 5.70e-01 | 0.0889 |
54681 | P4HTM | P9T-E | Human | Esophagus | ESCC | 2.90e-08 | 2.24e-01 | 0.1131 |
54681 | P4HTM | P10T-E | Human | Esophagus | ESCC | 6.69e-14 | 1.05e-01 | 0.116 |
54681 | P4HTM | P11T-E | Human | Esophagus | ESCC | 5.94e-09 | 3.60e-01 | 0.1426 |
54681 | P4HTM | P12T-E | Human | Esophagus | ESCC | 1.76e-18 | 3.30e-01 | 0.1122 |
54681 | P4HTM | P15T-E | Human | Esophagus | ESCC | 2.36e-16 | 3.22e-01 | 0.1149 |
54681 | P4HTM | P17T-E | Human | Esophagus | ESCC | 8.12e-07 | 2.85e-01 | 0.1278 |
54681 | P4HTM | P20T-E | Human | Esophagus | ESCC | 1.81e-08 | 1.79e-01 | 0.1124 |
54681 | P4HTM | P21T-E | Human | Esophagus | ESCC | 6.54e-08 | 1.75e-01 | 0.1617 |
54681 | P4HTM | P23T-E | Human | Esophagus | ESCC | 4.89e-09 | 1.70e-01 | 0.108 |
54681 | P4HTM | P24T-E | Human | Esophagus | ESCC | 2.93e-19 | 2.70e-01 | 0.1287 |
54681 | P4HTM | P26T-E | Human | Esophagus | ESCC | 1.38e-20 | 3.99e-01 | 0.1276 |
54681 | P4HTM | P27T-E | Human | Esophagus | ESCC | 4.60e-19 | 3.33e-01 | 0.1055 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030099111 | Esophagus | ESCC | myeloid cell differentiation | 232/8552 | 381/18723 | 1.22e-09 | 2.90e-08 | 232 |
GO:0002262111 | Esophagus | ESCC | myeloid cell homeostasis | 104/8552 | 157/18723 | 1.49e-07 | 2.36e-06 | 104 |
GO:001820816 | Esophagus | ESCC | peptidyl-proline modification | 46/8552 | 58/18723 | 1.59e-07 | 2.51e-06 | 46 |
GO:0034101111 | Esophagus | ESCC | erythrocyte homeostasis | 88/8552 | 129/18723 | 1.81e-07 | 2.84e-06 | 88 |
GO:0048872111 | Esophagus | ESCC | homeostasis of number of cells | 163/8552 | 272/18723 | 1.40e-06 | 1.69e-05 | 163 |
GO:0030218111 | Esophagus | ESCC | erythrocyte differentiation | 80/8552 | 120/18723 | 2.69e-06 | 3.08e-05 | 80 |
GO:00181263 | Esophagus | ESCC | protein hydroxylation | 23/8552 | 27/18723 | 2.60e-05 | 2.19e-04 | 23 |
GO:1903706110 | Esophagus | ESCC | regulation of hemopoiesis | 201/8552 | 367/18723 | 2.60e-04 | 1.58e-03 | 201 |
GO:00195114 | Esophagus | ESCC | peptidyl-proline hydroxylation | 13/8552 | 15/18723 | 1.31e-03 | 6.26e-03 | 13 |
GO:0045637111 | Esophagus | ESCC | regulation of myeloid cell differentiation | 118/8552 | 210/18723 | 1.35e-03 | 6.43e-03 | 118 |
GO:004564619 | Esophagus | ESCC | regulation of erythrocyte differentiation | 32/8552 | 47/18723 | 1.59e-03 | 7.43e-03 | 32 |
GO:00184014 | Esophagus | ESCC | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:003009912 | Liver | Cirrhotic | myeloid cell differentiation | 135/4634 | 381/18723 | 1.69e-06 | 3.22e-05 | 135 |
GO:003410112 | Liver | Cirrhotic | erythrocyte homeostasis | 54/4634 | 129/18723 | 1.41e-05 | 1.97e-04 | 54 |
GO:00302187 | Liver | Cirrhotic | erythrocyte differentiation | 50/4634 | 120/18723 | 3.35e-05 | 4.13e-04 | 50 |
GO:000226212 | Liver | Cirrhotic | myeloid cell homeostasis | 59/4634 | 157/18723 | 2.33e-04 | 2.11e-03 | 59 |
GO:00182084 | Liver | Cirrhotic | peptidyl-proline modification | 26/4634 | 58/18723 | 6.65e-04 | 5.04e-03 | 26 |
GO:004887212 | Liver | Cirrhotic | homeostasis of number of cells | 89/4634 | 272/18723 | 1.76e-03 | 1.12e-02 | 89 |
GO:00456377 | Liver | Cirrhotic | regulation of myeloid cell differentiation | 68/4634 | 210/18723 | 7.40e-03 | 3.53e-02 | 68 |
GO:001820811 | Liver | HCC | peptidyl-proline modification | 42/7958 | 58/18723 | 3.73e-06 | 4.85e-05 | 42 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
P4HTM | SNV | Missense_Mutation | novel | c.702N>G | p.Ile234Met | p.I234M | Q9NXG6 | protein_coding | deleterious(0.01) | possibly_damaging(0.753) | TCGA-BA-4077-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cetuximab | PD |
P4HTM | SNV | Missense_Mutation | novel | c.995N>A | p.Gly332Glu | p.G332E | Q9NXG6 | protein_coding | tolerated(0.12) | possibly_damaging(0.76) | TCGA-CV-6952-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
P4HTM | SNV | Missense_Mutation | novel | c.343G>C | p.Glu115Gln | p.E115Q | Q9NXG6 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-CV-A463-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
P4HTM | SNV | Missense_Mutation | c.1679G>A | p.Arg560His | p.R560H | Q9NXG6 | protein_coding | tolerated_low_confidence(0.78) | benign(0) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
P4HTM | SNV | Missense_Mutation | rs768160824 | c.508N>T | p.Arg170Cys | p.R170C | Q9NXG6 | protein_coding | deleterious(0.02) | possibly_damaging(0.878) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
P4HTM | SNV | Missense_Mutation | novel | c.1169N>C | p.Met390Thr | p.M390T | Q9NXG6 | protein_coding | tolerated_low_confidence(0.62) | benign(0) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
P4HTM | SNV | Missense_Mutation | c.139N>T | p.Arg47Cys | p.R47C | Q9NXG6 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.951) | TCGA-BR-4366-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
P4HTM | SNV | Missense_Mutation | c.1039G>A | p.Ala347Thr | p.A347T | Q9NXG6 | protein_coding | tolerated(0.13) | benign(0.122) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | |
P4HTM | SNV | Missense_Mutation | novel | c.920N>G | p.Ile307Ser | p.I307S | Q9NXG6 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
P4HTM | insertion | Frame_Shift_Ins | rs760453324 | c.1239_1240insC | p.Leu416ProfsTer28 | p.L416Pfs*28 | Q9NXG6 | protein_coding | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
54681 | P4HTM | TRANSCRIPTION FACTOR, DRUGGABLE GENOME | inhibitor | CHEMBL3544988 | DAPRODUSTAT | |
54681 | P4HTM | TRANSCRIPTION FACTOR, DRUGGABLE GENOME | inhibitor | CHEMBL2338329 | ROXADUSTAT |
Page: 1 |