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Gene: OSBPL2 |
Gene summary for OSBPL2 |
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Gene information | Species | Human | Gene symbol | OSBPL2 | Gene ID | 9885 |
Gene name | oxysterol binding protein like 2 | |
Gene Alias | DFNA67 | |
Cytomap | 20q13.33 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | B4DKJ8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9885 | OSBPL2 | LZE4T | Human | Esophagus | ESCC | 1.89e-11 | 3.27e-01 | 0.0811 |
9885 | OSBPL2 | LZE5T | Human | Esophagus | ESCC | 1.26e-02 | 2.14e-01 | 0.0514 |
9885 | OSBPL2 | LZE7T | Human | Esophagus | ESCC | 1.04e-05 | 2.13e-01 | 0.0667 |
9885 | OSBPL2 | LZE8T | Human | Esophagus | ESCC | 1.54e-03 | 1.12e-01 | 0.067 |
9885 | OSBPL2 | LZE20T | Human | Esophagus | ESCC | 3.03e-08 | 2.78e-01 | 0.0662 |
9885 | OSBPL2 | LZE24T | Human | Esophagus | ESCC | 6.65e-09 | 3.80e-01 | 0.0596 |
9885 | OSBPL2 | P1T-E | Human | Esophagus | ESCC | 3.34e-12 | 4.92e-01 | 0.0875 |
9885 | OSBPL2 | P2T-E | Human | Esophagus | ESCC | 2.60e-24 | 2.59e-01 | 0.1177 |
9885 | OSBPL2 | P4T-E | Human | Esophagus | ESCC | 3.12e-09 | 1.45e-01 | 0.1323 |
9885 | OSBPL2 | P5T-E | Human | Esophagus | ESCC | 4.01e-30 | 1.55e-01 | 0.1327 |
9885 | OSBPL2 | P8T-E | Human | Esophagus | ESCC | 3.22e-19 | 1.78e-01 | 0.0889 |
9885 | OSBPL2 | P9T-E | Human | Esophagus | ESCC | 1.41e-13 | 1.44e-01 | 0.1131 |
9885 | OSBPL2 | P10T-E | Human | Esophagus | ESCC | 4.62e-22 | 3.81e-01 | 0.116 |
9885 | OSBPL2 | P11T-E | Human | Esophagus | ESCC | 2.57e-09 | 5.52e-01 | 0.1426 |
9885 | OSBPL2 | P12T-E | Human | Esophagus | ESCC | 7.56e-22 | 4.84e-01 | 0.1122 |
9885 | OSBPL2 | P15T-E | Human | Esophagus | ESCC | 1.08e-20 | 3.22e-01 | 0.1149 |
9885 | OSBPL2 | P16T-E | Human | Esophagus | ESCC | 1.20e-12 | 3.39e-01 | 0.1153 |
9885 | OSBPL2 | P17T-E | Human | Esophagus | ESCC | 1.53e-05 | 1.17e-01 | 0.1278 |
9885 | OSBPL2 | P20T-E | Human | Esophagus | ESCC | 2.89e-27 | 6.96e-01 | 0.1124 |
9885 | OSBPL2 | P21T-E | Human | Esophagus | ESCC | 2.94e-22 | 3.97e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00463948 | Esophagus | ESCC | carboxylic acid biosynthetic process | 175/8552 | 314/18723 | 1.98e-04 | 1.26e-03 | 175 |
GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
GO:00512623 | Esophagus | ESCC | protein tetramerization | 54/8552 | 87/18723 | 1.50e-03 | 7.06e-03 | 54 |
GO:00066946 | Esophagus | ESCC | steroid biosynthetic process | 98/8552 | 173/18723 | 2.34e-03 | 1.03e-02 | 98 |
GO:00512592 | Esophagus | ESCC | protein complex oligomerization | 130/8552 | 238/18723 | 3.29e-03 | 1.36e-02 | 130 |
GO:19016174 | Esophagus | ESCC | organic hydroxy compound biosynthetic process | 128/8552 | 237/18723 | 5.86e-03 | 2.16e-02 | 128 |
GO:00323661 | Esophagus | ESCC | intracellular sterol transport | 20/8552 | 29/18723 | 9.66e-03 | 3.34e-02 | 20 |
GO:00323671 | Esophagus | ESCC | intracellular cholesterol transport | 20/8552 | 29/18723 | 9.66e-03 | 3.34e-02 | 20 |
GO:001605321 | Liver | HCC | organic acid biosynthetic process | 200/7958 | 316/18723 | 5.24e-14 | 3.22e-12 | 200 |
GO:004639421 | Liver | HCC | carboxylic acid biosynthetic process | 198/7958 | 314/18723 | 1.19e-13 | 6.78e-12 | 198 |
GO:00082022 | Liver | HCC | steroid metabolic process | 188/7958 | 319/18723 | 1.96e-09 | 5.63e-08 | 188 |
GO:007233021 | Liver | HCC | monocarboxylic acid biosynthetic process | 129/7958 | 214/18723 | 1.08e-07 | 2.09e-06 | 129 |
GO:00066942 | Liver | HCC | steroid biosynthetic process | 104/7958 | 173/18723 | 2.13e-06 | 2.91e-05 | 104 |
GO:00082062 | Liver | HCC | bile acid metabolic process | 34/7958 | 49/18723 | 1.28e-04 | 1.06e-03 | 34 |
GO:19016172 | Liver | HCC | organic hydroxy compound biosynthetic process | 129/7958 | 237/18723 | 1.32e-04 | 1.08e-03 | 129 |
GO:001087621 | Liver | HCC | lipid localization | 228/7958 | 448/18723 | 1.80e-04 | 1.41e-03 | 228 |
GO:01200092 | Liver | HCC | intermembrane lipid transfer | 33/7958 | 48/18723 | 2.12e-04 | 1.63e-03 | 33 |
GO:00066992 | Liver | HCC | bile acid biosynthetic process | 26/7958 | 36/18723 | 2.93e-04 | 2.10e-03 | 26 |
GO:000686921 | Liver | HCC | lipid transport | 198/7958 | 398/18723 | 1.92e-03 | 9.78e-03 | 198 |
GO:00303012 | Liver | HCC | cholesterol transport | 65/7958 | 117/18723 | 2.95e-03 | 1.38e-02 | 65 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OSBPL2 | SNV | Missense_Mutation | c.496G>C | p.Asp166His | p.D166H | Q9H1P3 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-69-7978-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
OSBPL2 | SNV | Missense_Mutation | novel | c.173N>G | p.Gln58Arg | p.Q58R | Q9H1P3 | protein_coding | tolerated(0.3) | benign(0) | TCGA-43-8115-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
OSBPL2 | SNV | Missense_Mutation | c.157N>G | p.Gln53Glu | p.Q53E | Q9H1P3 | protein_coding | tolerated(0.31) | benign(0.044) | TCGA-66-2768-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
OSBPL2 | SNV | Missense_Mutation | novel | c.468N>C | p.Leu156Phe | p.L156F | Q9H1P3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-77-8136-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
OSBPL2 | SNV | Missense_Mutation | novel | c.547N>G | p.Ser183Gly | p.S183G | Q9H1P3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-NK-A5CX-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OSBPL2 | deletion | Frame_Shift_Del | c.963delN | p.Arg322GlyfsTer6 | p.R322Gfs*6 | Q9H1P3 | protein_coding | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD | |||
OSBPL2 | SNV | Missense_Mutation | novel | c.680N>G | p.Asn227Ser | p.N227S | Q9H1P3 | protein_coding | tolerated(0.11) | benign(0.021) | TCGA-CQ-7072-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
OSBPL2 | SNV | Missense_Mutation | novel | c.73G>A | p.Glu25Lys | p.E25K | Q9H1P3 | protein_coding | tolerated(0.09) | benign(0.269) | TCGA-CV-7095-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OSBPL2 | SNV | Missense_Mutation | novel | c.172N>G | p.Gln58Glu | p.Q58E | Q9H1P3 | protein_coding | tolerated(0.22) | benign(0) | TCGA-CV-7177-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
OSBPL2 | SNV | Missense_Mutation | rs757263045 | c.938N>T | p.Ser313Leu | p.S313L | Q9H1P3 | protein_coding | tolerated(0.38) | benign(0.001) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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