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Gene: OSBP2 |
Gene summary for OSBP2 |
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Gene information | Species | Human | Gene symbol | OSBP2 | Gene ID | 23762 |
Gene name | oxysterol binding protein 2 | |
Gene Alias | HLM | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q969R2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23762 | OSBP2 | CCI_1 | Human | Cervix | CC | 1.49e-06 | 3.45e-01 | 0.528 |
23762 | OSBP2 | CCI_3 | Human | Cervix | CC | 1.51e-04 | 2.18e-01 | 0.516 |
23762 | OSBP2 | CCII_1 | Human | Cervix | CC | 1.30e-02 | 1.40e-01 | 0.3249 |
23762 | OSBP2 | sample1 | Human | Cervix | CC | 2.80e-20 | 5.15e-01 | 0.0959 |
23762 | OSBP2 | T1 | Human | Cervix | CC | 2.04e-34 | 6.07e-01 | 0.0918 |
23762 | OSBP2 | AEH-subject5 | Human | Endometrium | AEH | 3.36e-02 | 1.41e-01 | -0.2953 |
23762 | OSBP2 | EEC-subject1 | Human | Endometrium | EEC | 1.82e-06 | 2.25e-01 | -0.2682 |
23762 | OSBP2 | EEC-subject5 | Human | Endometrium | EEC | 8.79e-03 | 1.52e-01 | -0.249 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OSBP2 | SNV | Missense_Mutation | novel | c.706N>T | p.Asp236Tyr | p.D236Y | Q969R2 | protein_coding | tolerated(0.09) | possibly_damaging(0.808) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
OSBP2 | SNV | Missense_Mutation | novel | c.2177N>C | p.Glu726Ala | p.E726A | Q969R2 | protein_coding | deleterious(0.02) | possibly_damaging(0.559) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OSBP2 | SNV | Missense_Mutation | rs766552778 | c.612C>G | p.Phe204Leu | p.F204L | Q969R2 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OSBP2 | SNV | Missense_Mutation | novel | c.1985C>T | p.Pro662Leu | p.P662L | Q969R2 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OSBP2 | SNV | Missense_Mutation | c.559G>T | p.Gly187Cys | p.G187C | Q969R2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-64-1679-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
OSBP2 | SNV | Missense_Mutation | novel | c.1354T>C | p.Tyr452His | p.Y452H | Q969R2 | protein_coding | deleterious(0.01) | possibly_damaging(0.905) | TCGA-69-8253-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
OSBP2 | SNV | Missense_Mutation | rs548187834 | c.2186G>A | p.Arg729Gln | p.R729Q | Q969R2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-22-5471-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
OSBP2 | SNV | Missense_Mutation | c.344G>A | p.Gly115Glu | p.G115E | Q969R2 | protein_coding | deleterious_low_confidence(0.01) | benign(0.011) | TCGA-34-5239-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | taxotere | SD | |
OSBP2 | SNV | Missense_Mutation | novel | c.2487N>A | p.Met829Ile | p.M829I | Q969R2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-58-8391-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
OSBP2 | SNV | Missense_Mutation | c.2354T>C | p.Leu785Pro | p.L785P | Q969R2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-60-2719-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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