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Gene: NUP133 |
Gene summary for NUP133 |
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Gene information | Species | Human | Gene symbol | NUP133 | Gene ID | 55746 |
Gene name | nucleoporin 133 | |
Gene Alias | GAMOS8 | |
Cytomap | 1q42.13 | |
Gene Type | protein-coding | GO ID | GO:0000972 | UniProtAcc | Q8WUM0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55746 | NUP133 | LZE2T | Human | Esophagus | ESCC | 2.76e-03 | 4.11e-01 | 0.082 |
55746 | NUP133 | LZE4T | Human | Esophagus | ESCC | 1.83e-13 | 2.63e-01 | 0.0811 |
55746 | NUP133 | LZE7T | Human | Esophagus | ESCC | 4.60e-11 | 4.95e-01 | 0.0667 |
55746 | NUP133 | LZE8T | Human | Esophagus | ESCC | 7.62e-03 | 7.81e-02 | 0.067 |
55746 | NUP133 | LZE22T | Human | Esophagus | ESCC | 2.23e-02 | 2.25e-01 | 0.068 |
55746 | NUP133 | LZE24T | Human | Esophagus | ESCC | 2.32e-10 | 2.17e-01 | 0.0596 |
55746 | NUP133 | LZE21T | Human | Esophagus | ESCC | 5.36e-03 | 2.45e-01 | 0.0655 |
55746 | NUP133 | P1T-E | Human | Esophagus | ESCC | 6.03e-10 | 5.30e-01 | 0.0875 |
55746 | NUP133 | P2T-E | Human | Esophagus | ESCC | 9.09e-25 | 4.75e-01 | 0.1177 |
55746 | NUP133 | P4T-E | Human | Esophagus | ESCC | 4.96e-09 | 1.42e-01 | 0.1323 |
55746 | NUP133 | P5T-E | Human | Esophagus | ESCC | 8.46e-11 | 2.99e-01 | 0.1327 |
55746 | NUP133 | P8T-E | Human | Esophagus | ESCC | 2.75e-08 | 2.16e-01 | 0.0889 |
55746 | NUP133 | P9T-E | Human | Esophagus | ESCC | 1.44e-04 | 1.54e-01 | 0.1131 |
55746 | NUP133 | P10T-E | Human | Esophagus | ESCC | 4.33e-25 | 4.40e-01 | 0.116 |
55746 | NUP133 | P11T-E | Human | Esophagus | ESCC | 5.20e-07 | 3.08e-01 | 0.1426 |
55746 | NUP133 | P12T-E | Human | Esophagus | ESCC | 4.72e-10 | 2.71e-01 | 0.1122 |
55746 | NUP133 | P15T-E | Human | Esophagus | ESCC | 3.35e-15 | 3.65e-01 | 0.1149 |
55746 | NUP133 | P16T-E | Human | Esophagus | ESCC | 2.61e-32 | 5.03e-01 | 0.1153 |
55746 | NUP133 | P17T-E | Human | Esophagus | ESCC | 2.12e-08 | 2.74e-01 | 0.1278 |
55746 | NUP133 | P19T-E | Human | Esophagus | ESCC | 6.03e-03 | 2.59e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:005123617 | Esophagus | ESCC | establishment of RNA localization | 134/8552 | 166/18723 | 1.23e-20 | 1.81e-18 | 134 |
GO:0051168110 | Esophagus | ESCC | nuclear export | 126/8552 | 154/18723 | 1.88e-20 | 2.65e-18 | 126 |
GO:005102815 | Esophagus | ESCC | mRNA transport | 110/8552 | 130/18723 | 2.76e-20 | 3.80e-18 | 110 |
GO:005065717 | Esophagus | ESCC | nucleic acid transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:005065817 | Esophagus | ESCC | RNA transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:001703818 | Esophagus | ESCC | protein import | 149/8552 | 206/18723 | 5.90e-15 | 3.31e-13 | 149 |
GO:007116612 | Esophagus | ESCC | ribonucleoprotein complex localization | 66/8552 | 77/18723 | 2.94e-13 | 1.38e-11 | 66 |
GO:007142612 | Esophagus | ESCC | ribonucleoprotein complex export from nucleus | 65/8552 | 76/18723 | 5.56e-13 | 2.50e-11 | 65 |
GO:000640512 | Esophagus | ESCC | RNA export from nucleus | 68/8552 | 84/18723 | 2.99e-11 | 1.01e-09 | 68 |
GO:00064064 | Esophagus | ESCC | mRNA export from nucleus | 51/8552 | 59/18723 | 7.98e-11 | 2.47e-09 | 51 |
GO:00714274 | Esophagus | ESCC | mRNA-containing ribonucleoprotein complex export from nucleus | 51/8552 | 59/18723 | 7.98e-11 | 2.47e-09 | 51 |
GO:000699713 | Esophagus | ESCC | nucleus organization | 96/8552 | 133/18723 | 4.66e-10 | 1.21e-08 | 96 |
GO:005117014 | Esophagus | ESCC | import into nucleus | 111/8552 | 159/18723 | 5.69e-10 | 1.44e-08 | 111 |
GO:000660613 | Esophagus | ESCC | protein import into nucleus | 108/8552 | 155/18723 | 1.16e-09 | 2.77e-08 | 108 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUP133 | SNV | Missense_Mutation | rs368257231 | c.412N>A | p.Val138Ile | p.V138I | Q8WUM0 | protein_coding | tolerated(0.2) | benign(0.007) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUP133 | SNV | Missense_Mutation | novel | c.2747C>T | p.Ser916Phe | p.S916F | Q8WUM0 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NUP133 | SNV | Missense_Mutation | novel | c.2348A>T | p.Glu783Val | p.E783V | Q8WUM0 | protein_coding | tolerated(0.1) | benign(0.102) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NUP133 | SNV | Missense_Mutation | novel | c.2774N>C | p.Leu925Ser | p.L925S | Q8WUM0 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
NUP133 | SNV | Missense_Mutation | rs764079404 | c.2779A>C | p.Asn927His | p.N927H | Q8WUM0 | protein_coding | deleterious(0.02) | benign(0.273) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
NUP133 | SNV | Missense_Mutation | novel | c.2512G>A | p.Glu838Lys | p.E838K | Q8WUM0 | protein_coding | tolerated(0.17) | probably_damaging(0.998) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
NUP133 | SNV | Missense_Mutation | novel | c.2917N>G | p.Leu973Val | p.L973V | Q8WUM0 | protein_coding | deleterious(0) | possibly_damaging(0.698) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NUP133 | SNV | Missense_Mutation | c.2311C>A | p.Pro771Thr | p.P771T | Q8WUM0 | protein_coding | tolerated(0.23) | possibly_damaging(0.675) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NUP133 | SNV | Missense_Mutation | c.1228C>T | p.Pro410Ser | p.P410S | Q8WUM0 | protein_coding | tolerated(0.12) | possibly_damaging(0.871) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NUP133 | SNV | Missense_Mutation | c.2240N>G | p.Asn747Ser | p.N747S | Q8WUM0 | protein_coding | tolerated(0.75) | benign(0) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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