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Gene: NUDCD1 |
Gene summary for NUDCD1 |
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Gene information | Species | Human | Gene symbol | NUDCD1 | Gene ID | 84955 |
Gene name | NudC domain containing 1 | |
Gene Alias | CML66 | |
Cytomap | 8q23.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q96RS6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84955 | NUDCD1 | LZE3D | Human | Esophagus | HGIN | 2.39e-02 | 5.85e-01 | 0.0668 |
84955 | NUDCD1 | LZE4T | Human | Esophagus | ESCC | 2.41e-06 | 1.96e-01 | 0.0811 |
84955 | NUDCD1 | LZE20T | Human | Esophagus | ESCC | 7.16e-08 | 1.36e-01 | 0.0662 |
84955 | NUDCD1 | LZE24T | Human | Esophagus | ESCC | 1.15e-07 | 1.66e-01 | 0.0596 |
84955 | NUDCD1 | LZE6T | Human | Esophagus | ESCC | 8.52e-06 | 1.26e-01 | 0.0845 |
84955 | NUDCD1 | P2T-E | Human | Esophagus | ESCC | 8.17e-25 | 4.03e-01 | 0.1177 |
84955 | NUDCD1 | P4T-E | Human | Esophagus | ESCC | 2.33e-22 | 5.45e-01 | 0.1323 |
84955 | NUDCD1 | P5T-E | Human | Esophagus | ESCC | 9.78e-09 | 2.52e-01 | 0.1327 |
84955 | NUDCD1 | P8T-E | Human | Esophagus | ESCC | 1.06e-14 | 2.51e-01 | 0.0889 |
84955 | NUDCD1 | P9T-E | Human | Esophagus | ESCC | 2.76e-16 | 2.21e-01 | 0.1131 |
84955 | NUDCD1 | P10T-E | Human | Esophagus | ESCC | 2.50e-13 | 2.86e-01 | 0.116 |
84955 | NUDCD1 | P11T-E | Human | Esophagus | ESCC | 1.17e-13 | 3.47e-01 | 0.1426 |
84955 | NUDCD1 | P12T-E | Human | Esophagus | ESCC | 1.33e-18 | 4.59e-01 | 0.1122 |
84955 | NUDCD1 | P15T-E | Human | Esophagus | ESCC | 1.75e-20 | 4.24e-01 | 0.1149 |
84955 | NUDCD1 | P16T-E | Human | Esophagus | ESCC | 1.72e-35 | 6.74e-01 | 0.1153 |
84955 | NUDCD1 | P17T-E | Human | Esophagus | ESCC | 4.68e-08 | 4.15e-01 | 0.1278 |
84955 | NUDCD1 | P19T-E | Human | Esophagus | ESCC | 4.66e-05 | 5.80e-01 | 0.1662 |
84955 | NUDCD1 | P20T-E | Human | Esophagus | ESCC | 1.68e-15 | 2.53e-01 | 0.1124 |
84955 | NUDCD1 | P21T-E | Human | Esophagus | ESCC | 3.20e-22 | 5.95e-01 | 0.1617 |
84955 | NUDCD1 | P22T-E | Human | Esophagus | ESCC | 8.40e-10 | 1.98e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUDCD1 | SNV | Missense_Mutation | novel | c.1746G>T | p.Glu582Asp | p.E582D | Q96RS6 | protein_coding | tolerated(0.48) | benign(0) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUDCD1 | SNV | Missense_Mutation | novel | c.1746N>T | p.Glu582Asp | p.E582D | Q96RS6 | protein_coding | tolerated(0.48) | benign(0) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
NUDCD1 | SNV | Missense_Mutation | rs751161368 | c.1547G>A | p.Arg516Gln | p.R516Q | Q96RS6 | protein_coding | deleterious(0.02) | benign(0.418) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NUDCD1 | SNV | Missense_Mutation | rs139666666 | c.442N>A | p.Ala148Thr | p.A148T | Q96RS6 | protein_coding | tolerated(0.47) | benign(0) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NUDCD1 | SNV | Missense_Mutation | novel | c.1454C>T | p.Ala485Val | p.A485V | Q96RS6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EY-A2OP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NUDCD1 | SNV | Missense_Mutation | rs760887727 | c.341N>A | p.Arg114His | p.R114H | Q96RS6 | protein_coding | deleterious(0.03) | probably_damaging(0.965) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NUDCD1 | insertion | Frame_Shift_Ins | novel | c.651dupA | p.Tyr218IlefsTer2 | p.Y218Ifs*2 | Q96RS6 | protein_coding | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
NUDCD1 | insertion | Frame_Shift_Ins | novel | c.1288_1289insA | p.Thr430AsnfsTer21 | p.T430Nfs*21 | Q96RS6 | protein_coding | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NUDCD1 | deletion | Frame_Shift_Del | novel | c.319delN | p.Asp107IlefsTer2 | p.D107Ifs*2 | Q96RS6 | protein_coding | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
NUDCD1 | insertion | Frame_Shift_Ins | novel | c.1054_1055insG | p.Asn352ArgfsTer2 | p.N352Rfs*2 | Q96RS6 | protein_coding | TCGA-B5-A11F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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