![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NUCB2 |
Gene summary for NUCB2 |
![]() |
Gene information | Species | Human | Gene symbol | NUCB2 | Gene ID | 4925 |
Gene name | nucleobindin 2 | |
Gene Alias | HEL-S-109 | |
Cytomap | 11p15.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q2L696 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4925 | NUCB2 | GSM4909285 | Human | Breast | IDC | 2.13e-03 | 3.20e-01 | 0.21 |
4925 | NUCB2 | GSM4909286 | Human | Breast | IDC | 1.07e-10 | -2.69e-01 | 0.1081 |
4925 | NUCB2 | GSM4909296 | Human | Breast | IDC | 4.94e-03 | 1.14e-01 | 0.1524 |
4925 | NUCB2 | GSM4909297 | Human | Breast | IDC | 1.45e-08 | 7.90e-02 | 0.1517 |
4925 | NUCB2 | GSM4909306 | Human | Breast | IDC | 3.00e-04 | 4.32e-01 | 0.1564 |
4925 | NUCB2 | GSM4909308 | Human | Breast | IDC | 1.46e-03 | 3.11e-01 | 0.158 |
4925 | NUCB2 | GSM4909311 | Human | Breast | IDC | 4.67e-29 | 1.11e-01 | 0.1534 |
4925 | NUCB2 | GSM4909312 | Human | Breast | IDC | 2.56e-06 | 2.15e-01 | 0.1552 |
4925 | NUCB2 | GSM4909319 | Human | Breast | IDC | 1.18e-31 | -3.27e-02 | 0.1563 |
4925 | NUCB2 | GSM4909320 | Human | Breast | IDC | 1.40e-02 | 7.75e-02 | 0.1575 |
4925 | NUCB2 | GSM4909321 | Human | Breast | IDC | 3.17e-07 | -1.18e-01 | 0.1559 |
4925 | NUCB2 | M5 | Human | Breast | IDC | 3.10e-06 | 6.96e-01 | 0.1598 |
4925 | NUCB2 | NCCBC14 | Human | Breast | DCIS | 4.11e-08 | 1.72e-01 | 0.2021 |
4925 | NUCB2 | NCCBC2 | Human | Breast | DCIS | 1.35e-03 | 3.48e-01 | 0.1554 |
4925 | NUCB2 | NCCBC5 | Human | Breast | DCIS | 8.35e-10 | 8.54e-02 | 0.2046 |
4925 | NUCB2 | P1 | Human | Breast | IDC | 1.59e-10 | -2.10e-01 | 0.1527 |
4925 | NUCB2 | P2 | Human | Breast | IDC | 2.83e-02 | 2.66e-01 | 0.21 |
4925 | NUCB2 | DCIS2 | Human | Breast | DCIS | 5.38e-47 | 4.25e-01 | 0.0085 |
4925 | NUCB2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.26e-12 | 3.32e-01 | 0.0155 |
4925 | NUCB2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.07e-11 | 7.31e-01 | -0.1808 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003166714 | Breast | IDC | response to nutrient levels | 62/1434 | 474/18723 | 2.33e-05 | 5.57e-04 | 62 |
GO:003166723 | Breast | DCIS | response to nutrient levels | 58/1390 | 474/18723 | 1.16e-04 | 2.03e-03 | 58 |
GO:00321021 | Breast | DCIS | negative regulation of response to external stimulus | 46/1390 | 420/18723 | 5.19e-03 | 3.81e-02 | 46 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:00316671 | Colorectum | SER | response to nutrient levels | 106/2897 | 474/18723 | 3.94e-05 | 1.00e-03 | 106 |
GO:00316672 | Colorectum | MSS | response to nutrient levels | 125/3467 | 474/18723 | 1.24e-05 | 2.88e-04 | 125 |
GO:003166716 | Endometrium | AEH | response to nutrient levels | 78/2100 | 474/18723 | 3.26e-04 | 3.64e-03 | 78 |
GO:003166717 | Endometrium | EEC | response to nutrient levels | 82/2168 | 474/18723 | 1.23e-04 | 1.64e-03 | 82 |
GO:0031667111 | Esophagus | ESCC | response to nutrient levels | 289/8552 | 474/18723 | 9.25e-12 | 3.47e-10 | 289 |
GO:003166712 | Liver | Cirrhotic | response to nutrient levels | 174/4634 | 474/18723 | 3.08e-09 | 1.27e-07 | 174 |
GO:003166722 | Liver | HCC | response to nutrient levels | 276/7958 | 474/18723 | 2.30e-12 | 1.08e-10 | 276 |
GO:003166720 | Oral cavity | OSCC | response to nutrient levels | 245/7305 | 474/18723 | 1.02e-08 | 2.10e-07 | 245 |
GO:0031667110 | Oral cavity | LP | response to nutrient levels | 165/4623 | 474/18723 | 3.87e-07 | 1.12e-05 | 165 |
GO:00321023 | Oral cavity | EOLP | negative regulation of response to external stimulus | 75/2218 | 420/18723 | 1.74e-04 | 1.80e-03 | 75 |
GO:003166725 | Oral cavity | EOLP | response to nutrient levels | 82/2218 | 474/18723 | 2.59e-04 | 2.52e-03 | 82 |
GO:003166732 | Oral cavity | NEOLP | response to nutrient levels | 77/2005 | 474/18723 | 1.27e-04 | 1.49e-03 | 77 |
GO:003210212 | Oral cavity | NEOLP | negative regulation of response to external stimulus | 63/2005 | 420/18723 | 3.67e-03 | 2.14e-02 | 63 |
GO:003166718 | Prostate | BPH | response to nutrient levels | 121/3107 | 474/18723 | 3.68e-07 | 7.70e-06 | 121 |
GO:003166719 | Prostate | Tumor | response to nutrient levels | 127/3246 | 474/18723 | 1.27e-07 | 3.28e-06 | 127 |
GO:0031667113 | Thyroid | PTC | response to nutrient levels | 201/5968 | 474/18723 | 7.00e-07 | 1.10e-05 | 201 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUCB2 | SNV | Missense_Mutation | c.589N>A | p.Glu197Lys | p.E197K | protein_coding | deleterious(0.04) | probably_damaging(0.974) | TCGA-43-6647-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | CR | ||
NUCB2 | SNV | Missense_Mutation | novel | c.973N>G | p.Lys325Glu | p.K325E | protein_coding | tolerated(0.21) | benign(0.046) | TCGA-60-2697-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cytoxan | PD | |
NUCB2 | SNV | Missense_Mutation | novel | c.1223N>T | p.Ser408Leu | p.S408L | protein_coding | tolerated_low_confidence(0.05) | benign(0.036) | TCGA-85-8354-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NUCB2 | SNV | Missense_Mutation | novel | c.838N>T | p.Pro280Ser | p.P280S | protein_coding | tolerated(0.13) | benign(0.287) | TCGA-85-A50Z-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | etoposide | PD | |
NUCB2 | insertion | Frame_Shift_Ins | novel | c.623_624insATATAGCATACTCTTGAAC | p.Glu209TyrfsTer13 | p.E209Yfs*13 | protein_coding | TCGA-62-A46V-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
NUCB2 | SNV | Missense_Mutation | novel | c.835N>C | p.Asp279His | p.D279H | protein_coding | deleterious(0) | possibly_damaging(0.815) | TCGA-BA-5152-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NUCB2 | SNV | Missense_Mutation | novel | c.95N>T | p.Thr32Ile | p.T32I | protein_coding | tolerated(0.07) | benign(0.215) | TCGA-KK-A8IK-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
NUCB2 | SNV | Missense_Mutation | rs771755760 | c.1129C>T | p.Arg377Cys | p.R377C | protein_coding | deleterious(0) | possibly_damaging(0.65) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
NUCB2 | SNV | Missense_Mutation | c.578N>G | p.Lys193Arg | p.K193R | protein_coding | tolerated(0.18) | possibly_damaging(0.802) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | ||
NUCB2 | SNV | Missense_Mutation | novel | c.695N>C | p.Val232Ala | p.V232A | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-VQ-A928-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4925 | NUCB2 | DRUGGABLE GENOME | hydrochlorothiazide | HYDROCHLOROTHIAZIDE | 31327267 |
Page: 1 |