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Gene: NUCB1 |
Gene summary for NUCB1 |
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Gene information | Species | Human | Gene symbol | NUCB1 | Gene ID | 4924 |
Gene name | nucleobindin 1 | |
Gene Alias | CALNUC | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | A8K7Q1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4924 | NUCB1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.30e-08 | 2.54e-01 | 0.0155 |
4924 | NUCB1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.00e-02 | 2.77e-01 | -0.1808 |
4924 | NUCB1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.47e-10 | 5.31e-01 | -0.0811 |
4924 | NUCB1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.43e-10 | 4.05e-01 | -0.1954 |
4924 | NUCB1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.78e-08 | 1.09e+00 | -0.2602 |
4924 | NUCB1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.74e-02 | 4.45e-01 | -0.1207 |
4924 | NUCB1 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.07e-03 | 4.33e-01 | -0.1526 |
4924 | NUCB1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.62e-18 | 5.14e-01 | -0.1464 |
4924 | NUCB1 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.20e-14 | 3.46e-01 | -0.1001 |
4924 | NUCB1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.94e-21 | 7.11e-01 | -0.059 |
4924 | NUCB1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 5.05e-04 | 6.06e-01 | -0.1462 |
4924 | NUCB1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.89e-03 | 3.58e-01 | -0.0842 |
4924 | NUCB1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.20e-04 | 2.20e-01 | 0.096 |
4924 | NUCB1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.63e-03 | 5.84e-01 | 0.0451 |
4924 | NUCB1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 5.35e-03 | 5.59e-01 | 0.0171 |
4924 | NUCB1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.25e-06 | 4.86e-01 | 0.0338 |
4924 | NUCB1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.47e-16 | 3.99e-01 | 0.0674 |
4924 | NUCB1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.83e-03 | 4.24e-01 | 0.0112 |
4924 | NUCB1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.35e-07 | 2.55e-01 | 0.294 |
4924 | NUCB1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.88e-02 | 5.22e-01 | 0.3487 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0033157 | Colorectum | AD | regulation of intracellular protein transport | 80/3918 | 229/18723 | 5.81e-07 | 2.09e-05 | 80 |
GO:1903533 | Colorectum | AD | regulation of protein targeting | 31/3918 | 81/18723 | 2.61e-04 | 3.25e-03 | 31 |
GO:00331571 | Colorectum | SER | regulation of intracellular protein transport | 68/2897 | 229/18723 | 3.41e-08 | 2.30e-06 | 68 |
GO:00323861 | Colorectum | SER | regulation of intracellular transport | 89/2897 | 337/18723 | 1.34e-07 | 7.96e-06 | 89 |
GO:00066051 | Colorectum | SER | protein targeting | 76/2897 | 314/18723 | 3.19e-05 | 8.47e-04 | 76 |
GO:19035331 | Colorectum | SER | regulation of protein targeting | 24/2897 | 81/18723 | 9.20e-04 | 1.11e-02 | 24 |
GO:00066052 | Colorectum | MSS | protein targeting | 97/3467 | 314/18723 | 6.76e-08 | 3.46e-06 | 97 |
GO:00331572 | Colorectum | MSS | regulation of intracellular protein transport | 76/3467 | 229/18723 | 7.03e-08 | 3.56e-06 | 76 |
GO:00323862 | Colorectum | MSS | regulation of intracellular transport | 102/3467 | 337/18723 | 9.73e-08 | 4.71e-06 | 102 |
GO:19035332 | Colorectum | MSS | regulation of protein targeting | 28/3467 | 81/18723 | 4.34e-04 | 5.23e-03 | 28 |
GO:00066053 | Colorectum | MSI-H | protein targeting | 44/1319 | 314/18723 | 9.50e-06 | 4.55e-04 | 44 |
GO:00323863 | Colorectum | MSI-H | regulation of intracellular transport | 46/1319 | 337/18723 | 1.20e-05 | 5.48e-04 | 46 |
GO:00331573 | Colorectum | MSI-H | regulation of intracellular protein transport | 33/1319 | 229/18723 | 6.86e-05 | 2.29e-03 | 33 |
GO:00323865 | Colorectum | CRC | regulation of intracellular transport | 61/2078 | 337/18723 | 7.94e-05 | 1.65e-03 | 61 |
GO:00331575 | Colorectum | CRC | regulation of intracellular protein transport | 45/2078 | 229/18723 | 9.62e-05 | 1.95e-03 | 45 |
GO:00066055 | Colorectum | CRC | protein targeting | 54/2078 | 314/18723 | 7.17e-04 | 9.28e-03 | 54 |
GO:000660525 | Esophagus | HGIN | protein targeting | 78/2587 | 314/18723 | 1.08e-07 | 5.47e-06 | 78 |
GO:003238617 | Esophagus | HGIN | regulation of intracellular transport | 79/2587 | 337/18723 | 1.11e-06 | 4.36e-05 | 79 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUCB1 | SNV | Missense_Mutation | novel | c.11N>T | p.Ser4Phe | p.S4F | Q02818 | protein_coding | deleterious_low_confidence(0) | benign(0.047) | TCGA-IQ-A61I-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NUCB1 | SNV | Missense_Mutation | c.67N>A | p.Ala23Thr | p.A23T | Q02818 | protein_coding | tolerated(0.22) | benign(0) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
NUCB1 | SNV | Missense_Mutation | novel | c.800N>T | p.Ala267Val | p.A267V | Q02818 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
NUCB1 | SNV | Missense_Mutation | novel | c.543N>A | p.Met181Ile | p.M181I | Q02818 | protein_coding | tolerated(0.07) | benign(0.118) | TCGA-D7-A74A-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NUCB1 | SNV | Missense_Mutation | c.67G>A | p.Ala23Thr | p.A23T | Q02818 | protein_coding | tolerated(0.22) | benign(0) | TCGA-HU-A4G9-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NUCB1 | SNV | Missense_Mutation | novel | c.725G>T | p.Arg242Met | p.R242M | Q02818 | protein_coding | tolerated(0.08) | benign(0.053) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD |
NUCB1 | SNV | Missense_Mutation | rs371661389 | c.286G>A | p.Val96Ile | p.V96I | Q02818 | protein_coding | tolerated(0.22) | benign(0.063) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD |
NUCB1 | insertion | Frame_Shift_Ins | rs771817906 | c.97dupG | p.Ala33GlyfsTer11 | p.A33Gfs*11 | Q02818 | protein_coding | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4924 | NUCB1 | DRUGGABLE GENOME | antagonist | 252166902 | ||
4924 | NUCB1 | DRUGGABLE GENOME | GS-5734 | REMDESIVIR | ||
4924 | NUCB1 | DRUGGABLE GENOME | antagonist | 252166718 |
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