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Gene: NT5E |
Gene summary for NT5E |
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Gene information | Species | Human | Gene symbol | NT5E | Gene ID | 4907 |
Gene name | 5'-nucleotidase ecto | |
Gene Alias | CALJA | |
Cytomap | 6q14.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P21589 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4907 | NT5E | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.92e-03 | 3.55e-01 | -0.1808 |
4907 | NT5E | HTA11_78_2000001011 | Human | Colorectum | AD | 2.45e-11 | 6.13e-01 | -0.1088 |
4907 | NT5E | HTA11_347_2000001011 | Human | Colorectum | AD | 2.71e-09 | 4.53e-01 | -0.1954 |
4907 | NT5E | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.61e-05 | 7.26e-01 | 0.0171 |
4907 | NT5E | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.10e-04 | 4.15e-01 | 0.0588 |
4907 | NT5E | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.18e-02 | 2.47e-01 | 0.3859 |
4907 | NT5E | LZE22T | Human | Esophagus | ESCC | 1.73e-02 | 2.83e-01 | 0.068 |
4907 | NT5E | LZE6T | Human | Esophagus | ESCC | 5.75e-04 | 5.11e-01 | 0.0845 |
4907 | NT5E | P5T-E | Human | Esophagus | ESCC | 9.38e-04 | 1.30e-01 | 0.1327 |
4907 | NT5E | P8T-E | Human | Esophagus | ESCC | 3.73e-45 | 1.08e+00 | 0.0889 |
4907 | NT5E | P9T-E | Human | Esophagus | ESCC | 3.93e-15 | 4.82e-01 | 0.1131 |
4907 | NT5E | P10T-E | Human | Esophagus | ESCC | 2.43e-04 | 3.44e-01 | 0.116 |
4907 | NT5E | P11T-E | Human | Esophagus | ESCC | 6.64e-03 | 3.35e-01 | 0.1426 |
4907 | NT5E | P15T-E | Human | Esophagus | ESCC | 1.04e-02 | 3.25e-01 | 0.1149 |
4907 | NT5E | P19T-E | Human | Esophagus | ESCC | 4.95e-02 | 7.55e-01 | 0.1662 |
4907 | NT5E | P21T-E | Human | Esophagus | ESCC | 1.13e-53 | 1.50e+00 | 0.1617 |
4907 | NT5E | P23T-E | Human | Esophagus | ESCC | 4.71e-05 | 2.89e-01 | 0.108 |
4907 | NT5E | P24T-E | Human | Esophagus | ESCC | 5.64e-05 | 4.01e-01 | 0.1287 |
4907 | NT5E | P30T-E | Human | Esophagus | ESCC | 4.12e-05 | 7.73e-01 | 0.137 |
4907 | NT5E | P32T-E | Human | Esophagus | ESCC | 2.39e-30 | 9.62e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0009135 | Colorectum | AD | purine nucleoside diphosphate metabolic process | 47/3918 | 103/18723 | 1.61e-08 | 9.22e-07 | 47 |
GO:0009179 | Colorectum | AD | purine ribonucleoside diphosphate metabolic process | 47/3918 | 103/18723 | 1.61e-08 | 9.22e-07 | 47 |
GO:0009185 | Colorectum | AD | ribonucleoside diphosphate metabolic process | 47/3918 | 106/18723 | 4.85e-08 | 2.55e-06 | 47 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0046031 | Colorectum | AD | ADP metabolic process | 41/3918 | 90/18723 | 1.37e-07 | 6.42e-06 | 41 |
GO:0009132 | Colorectum | AD | nucleoside diphosphate metabolic process | 49/3918 | 124/18723 | 1.75e-06 | 5.31e-05 | 49 |
GO:0072522 | Colorectum | AD | purine-containing compound biosynthetic process | 68/3918 | 200/18723 | 1.12e-05 | 2.55e-04 | 68 |
GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
GO:0009126 | Colorectum | AD | purine nucleoside monophosphate metabolic process | 19/3918 | 44/18723 | 7.13e-04 | 7.21e-03 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa002405 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0024012 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa002402 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa002403 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa002404 | Oral cavity | OSCC | Pyrimidine metabolism | 37/3704 | 58/8465 | 1.62e-03 | 4.45e-03 | 2.26e-03 | 37 |
hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0024011 | Oral cavity | OSCC | Pyrimidine metabolism | 37/3704 | 58/8465 | 1.62e-03 | 4.45e-03 | 2.26e-03 | 37 |
hsa0123221 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
hsa0024021 | Oral cavity | LP | Pyrimidine metabolism | 28/2418 | 58/8465 | 1.12e-03 | 5.02e-03 | 3.24e-03 | 28 |
hsa0123231 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
hsa0024031 | Oral cavity | LP | Pyrimidine metabolism | 28/2418 | 58/8465 | 1.12e-03 | 5.02e-03 | 3.24e-03 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NT5E | deletion | Frame_Shift_Del | novel | c.1110_1134delCAACAACCTGAGACACACGGATGAA | p.Asn370LysfsTer12 | p.N370Kfs*12 | P21589 | protein_coding | TCGA-AJ-A23M-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | unknown | PD | ||
NT5E | SNV | Missense_Mutation | novel | c.443G>A | p.Gly148Glu | p.G148E | P21589 | protein_coding | tolerated(0.9) | benign(0.006) | TCGA-K7-AAU7-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Chemotherapy | gemcitabine | PD |
NT5E | SNV | Missense_Mutation | novel | c.470N>C | p.Leu157Pro | p.L157P | P21589 | protein_coding | tolerated(0.06) | possibly_damaging(0.878) | TCGA-05-4397-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NT5E | SNV | Missense_Mutation | c.1680N>C | p.Leu560Phe | p.L560F | P21589 | protein_coding | deleterious(0.04) | benign(0.293) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
NT5E | SNV | Missense_Mutation | c.1246C>A | p.Pro416Thr | p.P416T | P21589 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
NT5E | SNV | Missense_Mutation | novel | c.649N>T | p.Ala217Ser | p.A217S | P21589 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-78-7537-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NT5E | SNV | Missense_Mutation | novel | c.550N>T | p.Leu184Phe | p.L184F | P21589 | protein_coding | deleterious(0) | possibly_damaging(0.796) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NT5E | SNV | Missense_Mutation | rs200840390 | c.715N>A | p.Val239Met | p.V239M | P21589 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-21-1083-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NT5E | SNV | Missense_Mutation | c.44C>A | p.Ala15Asp | p.A15D | P21589 | protein_coding | tolerated(0.2) | benign(0.047) | TCGA-22-4593-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NT5E | SNV | Missense_Mutation | c.788N>T | p.Tyr263Phe | p.Y263F | P21589 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-22-5489-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | taxotere | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4907 | NT5E | ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | inhibitor | 404859154 | ||
4907 | NT5E | ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | PMID28870136-Compound-64 | |||
4907 | NT5E | ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | PMID28870136-Compound-44 | |||
4907 | NT5E | ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | PMID28870136-Compound-50 | |||
4907 | NT5E | ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | INOSITOL | INOSITOL | 2847980 | |
4907 | NT5E | ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | PMID28870136-Compound-58 | |||
4907 | NT5E | ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | PMID28870136-Compound-57 | |||
4907 | NT5E | ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | PMID28870136-Compound-38 | |||
4907 | NT5E | ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | PMID28870136-Compound-42 | |||
4907 | NT5E | ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE, DRUGGABLE GENOME | PMID28870136-Compound-51 |
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