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Gene: NRK |
Gene summary for NRK |
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Gene information | Species | Human | Gene symbol | NRK | Gene ID | 203447 |
Gene name | Nik related kinase | |
Gene Alias | NESK | |
Cytomap | Xq22.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q7Z2Y5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
203447 | NRK | ATC13 | Human | Thyroid | ATC | 1.61e-39 | 7.98e-01 | 0.34 |
203447 | NRK | ATC5 | Human | Thyroid | ATC | 1.13e-41 | 8.40e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003009912 | Liver | Cirrhotic | myeloid cell differentiation | 135/4634 | 381/18723 | 1.69e-06 | 3.22e-05 | 135 |
GO:003009922 | Liver | HCC | myeloid cell differentiation | 200/7958 | 381/18723 | 4.64e-05 | 4.49e-04 | 200 |
GO:003009928 | Skin | AK | myeloid cell differentiation | 72/1910 | 381/18723 | 1.76e-07 | 7.28e-06 | 72 |
GO:0030099112 | Skin | SCCIS | myeloid cell differentiation | 41/919 | 381/18723 | 2.11e-06 | 1.09e-04 | 41 |
GO:003009929 | Skin | cSCC | myeloid cell differentiation | 146/4864 | 381/18723 | 6.38e-08 | 1.61e-06 | 146 |
GO:0031532111 | Thyroid | ATC | actin cytoskeleton reorganization | 62/6293 | 107/18723 | 2.01e-07 | 3.17e-06 | 62 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NRK | SNV | Missense_Mutation | novel | c.1570N>T | p.Asp524Tyr | p.D524Y | Q7Z2Y5 | protein_coding | deleterious(0) | benign(0.259) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NRK | SNV | Missense_Mutation | rs755044109 | c.3167N>A | p.Gly1056Asp | p.G1056D | Q7Z2Y5 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NRK | SNV | Missense_Mutation | c.901N>T | p.Arg301Cys | p.R301C | Q7Z2Y5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NRK | SNV | Missense_Mutation | c.2645N>T | p.Pro882Leu | p.P882L | Q7Z2Y5 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
NRK | SNV | Missense_Mutation | novel | c.481N>G | p.Ile161Val | p.I161V | Q7Z2Y5 | protein_coding | tolerated(0.19) | benign(0.038) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NRK | SNV | Missense_Mutation | c.3080N>T | p.Ser1027Ile | p.S1027I | Q7Z2Y5 | protein_coding | tolerated(0.08) | benign(0.011) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NRK | SNV | Missense_Mutation | c.3283N>A | p.Ala1095Thr | p.A1095T | Q7Z2Y5 | protein_coding | tolerated(0.52) | benign(0) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |
NRK | SNV | Missense_Mutation | c.3799N>T | p.Gly1267Cys | p.G1267C | Q7Z2Y5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4614-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NRK | SNV | Missense_Mutation | novel | c.661N>A | p.Pro221Thr | p.P221T | Q7Z2Y5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-5407-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NRK | SNV | Missense_Mutation | novel | c.5N>T | p.Ala2Val | p.A2V | Q7Z2Y5 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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