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Gene: NRG1 |
Gene summary for NRG1 |
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Gene information | Species | Human | Gene symbol | NRG1 | Gene ID | 3084 |
Gene name | neuregulin 1 | |
Gene Alias | ARIA | |
Cytomap | 8p12 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A6MW56 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3084 | NRG1 | LZE4T | Human | Esophagus | ESCC | 4.08e-07 | 1.75e-01 | 0.0811 |
3084 | NRG1 | P2T-E | Human | Esophagus | ESCC | 1.06e-07 | -8.89e-02 | 0.1177 |
3084 | NRG1 | P4T-E | Human | Esophagus | ESCC | 1.84e-05 | 4.37e-01 | 0.1323 |
3084 | NRG1 | P5T-E | Human | Esophagus | ESCC | 5.68e-07 | 2.48e-01 | 0.1327 |
3084 | NRG1 | P8T-E | Human | Esophagus | ESCC | 8.44e-03 | 5.55e-02 | 0.0889 |
3084 | NRG1 | P9T-E | Human | Esophagus | ESCC | 5.44e-03 | 2.87e-01 | 0.1131 |
3084 | NRG1 | P12T-E | Human | Esophagus | ESCC | 9.55e-10 | 4.93e-01 | 0.1122 |
3084 | NRG1 | P15T-E | Human | Esophagus | ESCC | 8.54e-20 | 8.56e-01 | 0.1149 |
3084 | NRG1 | P16T-E | Human | Esophagus | ESCC | 1.52e-08 | -1.54e-03 | 0.1153 |
3084 | NRG1 | P21T-E | Human | Esophagus | ESCC | 3.99e-31 | 1.44e+00 | 0.1617 |
3084 | NRG1 | P22T-E | Human | Esophagus | ESCC | 5.24e-04 | 1.32e-02 | 0.1236 |
3084 | NRG1 | P26T-E | Human | Esophagus | ESCC | 1.88e-29 | 9.50e-01 | 0.1276 |
3084 | NRG1 | P27T-E | Human | Esophagus | ESCC | 6.09e-07 | -1.32e-01 | 0.1055 |
3084 | NRG1 | P28T-E | Human | Esophagus | ESCC | 2.93e-04 | 3.28e-01 | 0.1149 |
3084 | NRG1 | P30T-E | Human | Esophagus | ESCC | 2.80e-27 | 1.75e+00 | 0.137 |
3084 | NRG1 | P31T-E | Human | Esophagus | ESCC | 1.73e-03 | -3.49e-02 | 0.1251 |
3084 | NRG1 | P32T-E | Human | Esophagus | ESCC | 1.22e-05 | 4.75e-01 | 0.1666 |
3084 | NRG1 | P37T-E | Human | Esophagus | ESCC | 9.22e-09 | 4.34e-01 | 0.1371 |
3084 | NRG1 | P39T-E | Human | Esophagus | ESCC | 4.66e-02 | -1.51e-01 | 0.0894 |
3084 | NRG1 | P40T-E | Human | Esophagus | ESCC | 2.83e-02 | 4.05e-01 | 0.109 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042176111 | Esophagus | ESCC | regulation of protein catabolic process | 280/8552 | 391/18723 | 8.65e-26 | 2.39e-23 | 280 |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:0031334111 | Esophagus | ESCC | positive regulation of protein-containing complex assembly | 166/8552 | 237/18723 | 2.06e-14 | 1.07e-12 | 166 |
GO:0048732111 | Esophagus | ESCC | gland development | 269/8552 | 436/18723 | 7.81e-12 | 2.95e-10 | 269 |
GO:0009895111 | Esophagus | ESCC | negative regulation of catabolic process | 201/8552 | 320/18723 | 3.88e-10 | 1.05e-08 | 201 |
GO:0042177111 | Esophagus | ESCC | negative regulation of protein catabolic process | 84/8552 | 121/18723 | 1.03e-07 | 1.69e-06 | 84 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:003812718 | Esophagus | ESCC | ERBB signaling pathway | 82/8552 | 121/18723 | 7.23e-07 | 9.40e-06 | 82 |
GO:004586018 | Esophagus | ESCC | positive regulation of protein kinase activity | 219/8552 | 386/18723 | 6.91e-06 | 6.97e-05 | 219 |
GO:003367420 | Esophagus | ESCC | positive regulation of kinase activity | 260/8552 | 467/18723 | 7.26e-06 | 7.22e-05 | 260 |
GO:004311218 | Esophagus | ESCC | receptor metabolic process | 104/8552 | 166/18723 | 7.44e-06 | 7.37e-05 | 104 |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00420636 | Esophagus | ESCC | gliogenesis | 172/8552 | 301/18723 | 3.75e-05 | 3.04e-04 | 172 |
GO:00488638 | Esophagus | ESCC | stem cell differentiation | 122/8552 | 206/18723 | 5.95e-05 | 4.59e-04 | 122 |
GO:003087914 | Esophagus | ESCC | mammary gland development | 85/8552 | 137/18723 | 8.11e-05 | 6.01e-04 | 85 |
GO:00100016 | Esophagus | ESCC | glial cell differentiation | 129/8552 | 225/18723 | 2.73e-04 | 1.65e-03 | 129 |
GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0152110 | Esophagus | ESCC | EGFR tyrosine kinase inhibitor resistance | 55/4205 | 79/8465 | 2.44e-04 | 8.78e-04 | 4.50e-04 | 55 |
hsa0401218 | Esophagus | ESCC | ErbB signaling pathway | 56/4205 | 85/8465 | 1.78e-03 | 5.24e-03 | 2.68e-03 | 56 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0152115 | Esophagus | ESCC | EGFR tyrosine kinase inhibitor resistance | 55/4205 | 79/8465 | 2.44e-04 | 8.78e-04 | 4.50e-04 | 55 |
hsa0401219 | Esophagus | ESCC | ErbB signaling pathway | 56/4205 | 85/8465 | 1.78e-03 | 5.24e-03 | 2.68e-03 | 56 |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa015219 | Oral cavity | OSCC | EGFR tyrosine kinase inhibitor resistance | 54/3704 | 79/8465 | 8.11e-06 | 3.72e-05 | 1.89e-05 | 54 |
hsa0401216 | Oral cavity | OSCC | ErbB signaling pathway | 55/3704 | 85/8465 | 7.46e-05 | 2.81e-04 | 1.43e-04 | 55 |
hsa05014112 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0152114 | Oral cavity | OSCC | EGFR tyrosine kinase inhibitor resistance | 54/3704 | 79/8465 | 8.11e-06 | 3.72e-05 | 1.89e-05 | 54 |
hsa0401217 | Oral cavity | OSCC | ErbB signaling pathway | 55/3704 | 85/8465 | 7.46e-05 | 2.81e-04 | 1.43e-04 | 55 |
hsa0501426 | Prostate | BPH | Amyotrophic lateral sclerosis | 151/1718 | 364/8465 | 3.37e-21 | 1.01e-19 | 6.25e-20 | 151 |
hsa015218 | Prostate | BPH | EGFR tyrosine kinase inhibitor resistance | 30/1718 | 79/8465 | 2.10e-04 | 1.13e-03 | 6.98e-04 | 30 |
hsa0401214 | Prostate | BPH | ErbB signaling pathway | 28/1718 | 85/8465 | 4.12e-03 | 1.45e-02 | 8.95e-03 | 28 |
hsa05014111 | Prostate | BPH | Amyotrophic lateral sclerosis | 151/1718 | 364/8465 | 3.37e-21 | 1.01e-19 | 6.25e-20 | 151 |
hsa0152113 | Prostate | BPH | EGFR tyrosine kinase inhibitor resistance | 30/1718 | 79/8465 | 2.10e-04 | 1.13e-03 | 6.98e-04 | 30 |
hsa0401215 | Prostate | BPH | ErbB signaling pathway | 28/1718 | 85/8465 | 4.12e-03 | 1.45e-02 | 8.95e-03 | 28 |
hsa0501427 | Prostate | Tumor | Amyotrophic lateral sclerosis | 155/1791 | 364/8465 | 3.41e-21 | 1.13e-19 | 6.99e-20 | 155 |
hsa0152123 | Prostate | Tumor | EGFR tyrosine kinase inhibitor resistance | 31/1791 | 79/8465 | 1.82e-04 | 1.08e-03 | 6.68e-04 | 31 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
NRG1 | ERBB3 | NRG1_ERBB3 | NRG | Breast | DCIS |
NRG1 | ERBB2_ERBB3 | NRG1_ERBB2_ERBB3 | NRG | Breast | DCIS |
NRG1 | ERBB3 | NRG1_ERBB3 | NRG | Cervix | CC |
NRG1 | ERBB4 | NRG1_ERBB4 | NRG | Cervix | CC |
NRG1 | ERBB2_ERBB4 | NRG1_ERBB2_ERBB4 | NRG | Cervix | CC |
NRG1 | ERBB3 | NRG1_ERBB3 | NRG | Cervix | Precancer |
NRG1 | ERBB2_ERBB3 | NRG1_ERBB2_ERBB3 | NRG | Cervix | Precancer |
NRG1 | ERBB3 | NRG1_ERBB3 | NRG | CRC | AD |
NRG1 | ERBB2_ERBB3 | NRG1_ERBB2_ERBB3 | NRG | CRC | AD |
NRG1 | ERBB3 | NRG1_ERBB3 | NRG | CRC | ADJ |
NRG1 | ERBB2_ERBB3 | NRG1_ERBB2_ERBB3 | NRG | CRC | ADJ |
NRG1 | ERBB4 | NRG1_ERBB4 | NRG | CRC | ADJ |
NRG1 | ERBB3 | NRG1_ERBB3 | NRG | CRC | FAP |
NRG1 | ERBB2_ERBB3 | NRG1_ERBB2_ERBB3 | NRG | CRC | FAP |
NRG1 | ERBB3 | NRG1_ERBB3 | NRG | CRC | MSS |
NRG1 | ERBB2_ERBB3 | NRG1_ERBB2_ERBB3 | NRG | CRC | MSS |
NRG1 | ERBB3 | NRG1_ERBB3 | NRG | Esophagus | ESCC |
NRG1 | ERBB2_ERBB3 | NRG1_ERBB2_ERBB3 | NRG | Esophagus | ESCC |
NRG1 | ERBB3 | NRG1_ERBB3 | NRG | GC | ADJ |
NRG1 | ERBB3 | NRG1_ERBB3 | NRG | GC | GC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NRG1 | SNV | Missense_Mutation | novel | c.1593N>C | p.Glu531Asp | p.E531D | Q02297 | protein_coding | deleterious(0.05) | benign(0.23) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NRG1 | SNV | Missense_Mutation | novel | c.1303N>T | p.Thr435Ser | p.T435S | Q02297 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NRG1 | SNV | Missense_Mutation | novel | c.1494N>G | p.His498Gln | p.H498Q | Q02297 | protein_coding | tolerated(0.59) | possibly_damaging(0.617) | TCGA-AG-A036-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
NRG1 | SNV | Missense_Mutation | novel | c.182N>A | p.Ser61Tyr | p.S61Y | Q02297 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NRG1 | SNV | Missense_Mutation | novel | c.927N>T | p.Glu309Asp | p.E309D | Q02297 | protein_coding | tolerated(0.07) | benign(0.007) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NRG1 | deletion | Frame_Shift_Del | c.266delN | p.Lys91SerfsTer24 | p.K91Sfs*24 | Q02297 | protein_coding | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
NRG1 | deletion | Frame_Shift_Del | c.266delN | p.Lys91SerfsTer24 | p.K91Sfs*24 | Q02297 | protein_coding | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
NRG1 | deletion | Frame_Shift_Del | c.266delN | p.Lys91SerfsTer24 | p.K91Sfs*24 | Q02297 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
NRG1 | SNV | Missense_Mutation | novel | c.526A>G | p.Thr176Ala | p.T176A | Q02297 | protein_coding | deleterious(0.05) | benign(0.021) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NRG1 | SNV | Missense_Mutation | novel | c.944A>G | p.Asn315Ser | p.N315S | Q02297 | protein_coding | deleterious(0.02) | possibly_damaging(0.672) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3084 | NRG1 | GROWTH FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, DRUG RESISTANCE, KINASE | NERVE GROWTH FACTOR | 11069896 | ||
3084 | NRG1 | GROWTH FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, DRUG RESISTANCE, KINASE | PERTUZUMAB | PERTUZUMAB | 29802158 | |
3084 | NRG1 | GROWTH FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, DRUG RESISTANCE, KINASE | ANTI-HER3 MONOCLONAL ANTIBODY GSK2849330 | 29610121 | ||
3084 | NRG1 | GROWTH FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, DRUG RESISTANCE, KINASE | PROGESTERONE | PROGESTERONE | 12529413 | |
3084 | NRG1 | GROWTH FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, DRUG RESISTANCE, KINASE | ISOPROTERENOL | ISOPROTERENOL | 14732742 | |
3084 | NRG1 | GROWTH FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, DRUG RESISTANCE, KINASE | ASPIRIN | ASPIRIN | 10921413 | |
3084 | NRG1 | GROWTH FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, DRUG RESISTANCE, KINASE | DEXAMETHASONE | DEXAMETHASONE | 7599067 | |
3084 | NRG1 | GROWTH FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, DRUG RESISTANCE, KINASE | CISPLATIN | CISPLATIN | 23390248 | |
3084 | NRG1 | GROWTH FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, DRUG RESISTANCE, KINASE | WORTMANNIN | WORTMANNIN | 10559227 | |
3084 | NRG1 | GROWTH FACTOR, CLINICALLY ACTIONABLE, DRUGGABLE GENOME, DRUG RESISTANCE, KINASE | GENISTEIN | GENISTEIN | 17539658 |
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