Tissue | Expression Dynamics | Abbreviation |
Breast | | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00075653 | Breast | Precancer | female pregnancy | 29/1080 | 193/18723 | 2.07e-06 | 7.31e-05 | 29 |
GO:00447063 | Breast | Precancer | multi-multicellular organism process | 31/1080 | 220/18723 | 3.73e-06 | 1.19e-04 | 31 |
GO:00106319 | Breast | Precancer | epithelial cell migration | 40/1080 | 357/18723 | 4.57e-05 | 9.71e-04 | 40 |
GO:00901329 | Breast | Precancer | epithelium migration | 40/1080 | 360/18723 | 5.51e-05 | 1.14e-03 | 40 |
GO:00506736 | Breast | Precancer | epithelial cell proliferation | 46/1080 | 437/18723 | 6.02e-05 | 1.23e-03 | 46 |
GO:00435426 | Breast | Precancer | endothelial cell migration | 33/1080 | 279/18723 | 7.28e-05 | 1.44e-03 | 33 |
GO:00901309 | Breast | Precancer | tissue migration | 40/1080 | 365/18723 | 7.48e-05 | 1.47e-03 | 40 |
GO:00106329 | Breast | Precancer | regulation of epithelial cell migration | 33/1080 | 292/18723 | 1.74e-04 | 2.86e-03 | 33 |
GO:00506786 | Breast | Precancer | regulation of epithelial cell proliferation | 40/1080 | 381/18723 | 1.88e-04 | 3.03e-03 | 40 |
GO:00016678 | Breast | Precancer | ameboidal-type cell migration | 47/1080 | 475/18723 | 2.19e-04 | 3.35e-03 | 47 |
GO:00018927 | Breast | Precancer | embryonic placenta development | 14/1080 | 82/18723 | 2.30e-04 | 3.48e-03 | 14 |
GO:00486087 | Breast | Precancer | reproductive structure development | 43/1080 | 424/18723 | 2.36e-04 | 3.56e-03 | 43 |
GO:00614587 | Breast | Precancer | reproductive system development | 43/1080 | 427/18723 | 2.75e-04 | 4.00e-03 | 43 |
GO:00105943 | Breast | Precancer | regulation of endothelial cell migration | 27/1080 | 232/18723 | 4.12e-04 | 5.55e-03 | 27 |
GO:00323555 | Breast | Precancer | response to estradiol | 19/1080 | 141/18723 | 4.81e-04 | 6.31e-03 | 19 |
GO:00018907 | Breast | Precancer | placenta development | 19/1080 | 144/18723 | 6.26e-04 | 7.78e-03 | 19 |
GO:00017017 | Breast | Precancer | in utero embryonic development | 35/1080 | 367/18723 | 2.47e-03 | 2.27e-02 | 35 |
GO:0060706 | Breast | Precancer | cell differentiation involved in embryonic placenta development | 6/1080 | 25/18723 | 2.49e-03 | 2.28e-02 | 6 |
GO:00305228 | Breast | Precancer | intracellular receptor signaling pathway | 27/1080 | 265/18723 | 2.99e-03 | 2.57e-02 | 27 |
GO:00513489 | Breast | Precancer | negative regulation of transferase activity | 27/1080 | 268/18723 | 3.49e-03 | 2.90e-02 | 27 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
NR2F2 | BAS | Breast | ADJ | COL4A1,AARD,IGFBP7, etc. | 1.45e-01 | |
NR2F2 | BAS | Breast | Healthy | RGS5,IGFBP5,ADIRF, etc. | 2.43e-01 | |
NR2F2 | COL | Cervix | HSIL_HPV | SLC40A1,KRT8,TM4SF4, etc. | 3.14e-01 | |
NR2F2 | IMGOB | Colorectum | FAP | COL16A1,SDK2,XBP1, etc. | 1.99e-01 | |
NR2F2 | GLAN | Endometrium | AEH | COL3A1,COL1A1,COL1A2, etc. | 2.43e-01 | |
NR2F2 | PERI | Esophagus | ESCC | IGFBP7,PTCH1,NR2F2-AS1, etc. | 2.29e-01 | |
NR2F2 | MSC | Esophagus | ESCC | IGFBP7,PTCH1,NR2F2-AS1, etc. | 2.58e-01 | |
NR2F2 | AT2L | Lung | Healthy | LUM,ZC3H14,TIMP3, etc. | 1.66e-01 | |
NR2F2 | PERI | Lung | AIS | RGS5,PDGFRB,DLC1, etc. | 1.79e-01 | |
NR2F2 | PERI | Lung | MIAC | RGS5,PDGFRB,DLC1, etc. | 1.72e-01 | |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NR2F2 | SNV | Missense_Mutation | | c.770N>G | p.Ala257Gly | p.A257G | P24468 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2Y-A9HB-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NR2F2 | SNV | Missense_Mutation | | c.403N>A | p.Arg135Ser | p.R135S | P24468 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MI-A75G-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NR2F2 | deletion | Nonsense_Mutation | novel | c.273_274delNN | p.Tyr91Ter | p.Y91* | P24468 | protein_coding | | | TCGA-CC-A1HT-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
NR2F2 | SNV | Missense_Mutation | novel | c.1061N>A | p.Pro354His | p.P354H | P24468 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD |
NR2F2 | SNV | Missense_Mutation | novel | c.641A>T | p.Glu214Val | p.E214V | P24468 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-56-7221-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NR2F2 | SNV | Missense_Mutation | | c.551N>A | p.Leu184Gln | p.L184Q | P24468 | protein_coding | tolerated(0.26) | possibly_damaging(0.864) | TCGA-60-2721-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NR2F2 | SNV | Missense_Mutation | novel | c.406N>G | p.Leu136Val | p.L136V | P24468 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-77-6843-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NR2F2 | SNV | Missense_Mutation | | c.751N>A | p.Glu251Lys | p.E251K | P24468 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NR2F2 | insertion | Frame_Shift_Ins | novel | c.838_839insTGTCCGCCGACCGGGTGGTCGCCTTTATGGACCACATACGGATCTTC | p.Gln296CysfsTer39 | p.Q296Cfs*39 | P24468 | protein_coding | | | TCGA-62-8395-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NR2F2 | SNV | Missense_Mutation | novel | c.312G>C | p.Lys104Asn | p.K104N | P24468 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BA-6869-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7026 | NR2F2 | NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | CYCLOHEXIMIDE | CYCLOHEXIMIDE | |
7026 | NR2F2 | NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | GNF-PF-1678 | CHEMBL580340 | |
7026 | NR2F2 | NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | TCMDC-125620 | CHEMBL530291 | |
7026 | NR2F2 | NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | RESACTIN A | RESACTIN A | |
7026 | NR2F2 | NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | PYRIDABEN | PYRIDABEN | |
7026 | NR2F2 | NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR, DRUGGABLE GENOME | | GNF-PF-4659 | CHEMBL584442 | |