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Gene: NPR3 |
Gene summary for NPR3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NPR3 | Gene ID | 4883 |
Gene name | natriuretic peptide receptor 3 | |
Gene Alias | ANP-C | |
Cytomap | 5p13.3 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P17342 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4883 | NPR3 | P5T-E | Human | Esophagus | ESCC | 1.43e-08 | 2.58e-01 | 0.1327 |
4883 | NPR3 | P10T-E | Human | Esophagus | ESCC | 1.20e-02 | 1.77e-02 | 0.116 |
4883 | NPR3 | P12T-E | Human | Esophagus | ESCC | 1.80e-37 | 9.47e-01 | 0.1122 |
4883 | NPR3 | P23T-E | Human | Esophagus | ESCC | 5.75e-08 | 5.33e-01 | 0.108 |
4883 | NPR3 | P26T-E | Human | Esophagus | ESCC | 1.32e-07 | 2.27e-01 | 0.1276 |
4883 | NPR3 | P27T-E | Human | Esophagus | ESCC | 1.06e-10 | 3.03e-01 | 0.1055 |
4883 | NPR3 | P28T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.87e-01 | 0.1149 |
4883 | NPR3 | P31T-E | Human | Esophagus | ESCC | 3.12e-09 | 3.20e-01 | 0.1251 |
4883 | NPR3 | P32T-E | Human | Esophagus | ESCC | 4.94e-03 | 1.74e-01 | 0.1666 |
4883 | NPR3 | P39T-E | Human | Esophagus | ESCC | 1.02e-10 | 2.16e-01 | 0.0894 |
4883 | NPR3 | P42T-E | Human | Esophagus | ESCC | 1.72e-07 | 4.62e-01 | 0.1175 |
4883 | NPR3 | P54T-E | Human | Esophagus | ESCC | 1.35e-06 | 1.81e-01 | 0.0975 |
4883 | NPR3 | P62T-E | Human | Esophagus | ESCC | 2.06e-05 | 2.56e-01 | 0.1302 |
4883 | NPR3 | P74T-E | Human | Esophagus | ESCC | 8.75e-03 | 6.22e-02 | 0.1479 |
4883 | NPR3 | P83T-E | Human | Esophagus | ESCC | 2.21e-27 | 8.39e-01 | 0.1738 |
4883 | NPR3 | P84T-E | Human | Esophagus | ESCC | 2.73e-04 | 5.67e-01 | 0.0933 |
4883 | NPR3 | P107T-E | Human | Esophagus | ESCC | 1.17e-07 | 3.67e-01 | 0.171 |
4883 | NPR3 | P128T-E | Human | Esophagus | ESCC | 5.86e-15 | 8.06e-01 | 0.1241 |
4883 | NPR3 | P130T-E | Human | Esophagus | ESCC | 1.04e-04 | 3.92e-01 | 0.1676 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00486597 | Esophagus | ESCC | smooth muscle cell proliferation | 103/8552 | 184/18723 | 3.08e-03 | 1.28e-02 | 103 |
GO:00486607 | Esophagus | ESCC | regulation of smooth muscle cell proliferation | 100/8552 | 180/18723 | 4.76e-03 | 1.85e-02 | 100 |
GO:00330025 | Esophagus | ESCC | muscle cell proliferation | 134/8552 | 248/18723 | 4.80e-03 | 1.86e-02 | 134 |
GO:00513534 | Esophagus | ESCC | positive regulation of oxidoreductase activity | 37/8552 | 59/18723 | 6.23e-03 | 2.29e-02 | 37 |
GO:01061066 | Esophagus | ESCC | cold-induced thermogenesis | 80/8552 | 144/18723 | 1.07e-02 | 3.65e-02 | 80 |
GO:01201616 | Esophagus | ESCC | regulation of cold-induced thermogenesis | 80/8552 | 144/18723 | 1.07e-02 | 3.65e-02 | 80 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NPR3 | SNV | Missense_Mutation | novel | c.1057T>A | p.Tyr353Asn | p.Y353N | P17342 | protein_coding | tolerated(0.79) | benign(0.02) | TCGA-DD-AAE7-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NPR3 | SNV | Missense_Mutation | rs760331365 | c.1040N>T | p.Gly347Val | p.G347V | P17342 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-35-4123-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NPR3 | SNV | Missense_Mutation | c.1541N>T | p.Arg514Met | p.R514M | P17342 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-38-4626-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
NPR3 | SNV | Missense_Mutation | c.259N>T | p.Gly87Trp | p.G87W | P17342 | protein_coding | tolerated(0.17) | possibly_damaging(0.836) | TCGA-44-2657-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NPR3 | SNV | Missense_Mutation | novel | c.588N>A | p.His196Gln | p.H196Q | P17342 | protein_coding | tolerated(0.78) | benign(0) | TCGA-44-7662-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NPR3 | SNV | Missense_Mutation | novel | c.1609C>A | p.His537Asn | p.H537N | P17342 | protein_coding | tolerated(1) | benign(0.01) | TCGA-55-6968-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | unknown | PD |
NPR3 | SNV | Missense_Mutation | novel | c.454N>A | p.Leu152Met | p.L152M | P17342 | protein_coding | deleterious(0.01) | possibly_damaging(0.777) | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NPR3 | SNV | Missense_Mutation | novel | c.1248C>A | p.Phe416Leu | p.F416L | P17342 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-62-A46R-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NPR3 | SNV | Missense_Mutation | novel | c.381N>T | p.Lys127Asn | p.K127N | P17342 | protein_coding | deleterious(0) | possibly_damaging(0.754) | TCGA-73-4658-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NPR3 | SNV | Missense_Mutation | c.1079N>C | p.Gly360Ala | p.G360A | P17342 | protein_coding | tolerated(0.6) | probably_damaging(1) | TCGA-78-7147-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4883 | NPR3 | DRUGGABLE GENOME | agonist | 178101592 | ||
4883 | NPR3 | DRUGGABLE GENOME | antagonist | 178101571 | ||
4883 | NPR3 | DRUGGABLE GENOME | antagonist | 178101717 | ||
4883 | NPR3 | DRUGGABLE GENOME | CARDIODILATIN | |||
4883 | NPR3 | DRUGGABLE GENOME | ANX-042 | 23694773 | ||
4883 | NPR3 | DRUGGABLE GENOME | antagonist | 178101732 | ||
4883 | NPR3 | DRUGGABLE GENOME | 178101546 | |||
4883 | NPR3 | DRUGGABLE GENOME | agonist | 315661152 | PL-3994 | |
4883 | NPR3 | DRUGGABLE GENOME | NESIRITIDE | NESIRITIDE | ||
4883 | NPR3 | DRUGGABLE GENOME | NESIRITIDE | NESIRITIDE |
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