Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0097193 | Colorectum | AD | intrinsic apoptotic signaling pathway | 108/3918 | 288/18723 | 6.25e-11 | 6.41e-09 | 108 |
GO:2001242 | Colorectum | AD | regulation of intrinsic apoptotic signaling pathway | 67/3918 | 164/18723 | 4.94e-09 | 3.16e-07 | 67 |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
GO:0062197 | Colorectum | AD | cellular response to chemical stress | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
GO:0034599 | Colorectum | AD | cellular response to oxidative stress | 94/3918 | 288/18723 | 2.03e-06 | 6.02e-05 | 94 |
GO:0007623 | Colorectum | AD | circadian rhythm | 72/3918 | 210/18723 | 4.50e-06 | 1.21e-04 | 72 |
GO:0048511 | Colorectum | AD | rhythmic process | 94/3918 | 298/18723 | 1.00e-05 | 2.34e-04 | 94 |
GO:1901214 | Colorectum | AD | regulation of neuron death | 99/3918 | 319/18723 | 1.26e-05 | 2.76e-04 | 99 |
GO:2001234 | Colorectum | AD | negative regulation of apoptotic signaling pathway | 74/3918 | 224/18723 | 1.49e-05 | 3.18e-04 | 74 |
GO:2001243 | Colorectum | AD | negative regulation of intrinsic apoptotic signaling pathway | 39/3918 | 98/18723 | 1.58e-05 | 3.34e-04 | 39 |
GO:0008631 | Colorectum | AD | intrinsic apoptotic signaling pathway in response to oxidative stress | 22/3918 | 45/18723 | 2.77e-05 | 5.24e-04 | 22 |
GO:1902175 | Colorectum | AD | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 16/3918 | 29/18723 | 5.32e-05 | 9.01e-04 | 16 |
GO:0051402 | Colorectum | AD | neuron apoptotic process | 77/3918 | 246/18723 | 8.07e-05 | 1.28e-03 | 77 |
GO:1901215 | Colorectum | AD | negative regulation of neuron death | 67/3918 | 208/18723 | 8.81e-05 | 1.35e-03 | 67 |
GO:0036473 | Colorectum | AD | cell death in response to oxidative stress | 35/3918 | 95/18723 | 2.58e-04 | 3.24e-03 | 35 |
GO:1903203 | Colorectum | AD | regulation of oxidative stress-induced neuron death | 14/3918 | 27/18723 | 3.72e-04 | 4.29e-03 | 14 |
GO:1903204 | Colorectum | AD | negative regulation of oxidative stress-induced neuron death | 11/3918 | 19/18723 | 4.66e-04 | 5.15e-03 | 11 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NONO | SNV | Missense_Mutation | | c.458N>A | p.Arg153Gln | p.R153Q | Q15233 | protein_coding | tolerated(0.09) | benign(0.063) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
NONO | SNV | Missense_Mutation | novel | c.160N>T | p.Gly54Cys | p.G54C | Q15233 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NONO | SNV | Missense_Mutation | | c.1110N>A | p.Phe370Leu | p.F370L | Q15233 | protein_coding | deleterious(0.04) | benign(0.111) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
NONO | SNV | Missense_Mutation | novel | c.1402N>T | p.Arg468Cys | p.R468C | Q15233 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.973) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
NONO | SNV | Missense_Mutation | novel | c.140N>C | p.Gln47Pro | p.Q47P | Q15233 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
NONO | SNV | Missense_Mutation | novel | c.1291A>C | p.Thr431Pro | p.T431P | Q15233 | protein_coding | tolerated(0.24) | benign(0) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NONO | SNV | Missense_Mutation | | c.304N>A | p.Glu102Lys | p.E102K | Q15233 | protein_coding | deleterious(0.01) | benign(0.159) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
NONO | SNV | Missense_Mutation | | c.1090N>T | p.Arg364Trp | p.R364W | Q15233 | protein_coding | deleterious(0.02) | possibly_damaging(0.898) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NONO | SNV | Missense_Mutation | novel | c.1402C>T | p.Arg468Cys | p.R468C | Q15233 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.973) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NONO | SNV | Missense_Mutation | novel | c.974G>T | p.Arg325Met | p.R325M | Q15233 | protein_coding | deleterious(0.02) | probably_damaging(0.962) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |