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Gene: NOL9 |
Gene summary for NOL9 |
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Gene information | Species | Human | Gene symbol | NOL9 | Gene ID | 79707 |
Gene name | nucleolar protein 9 | |
Gene Alias | Grc3 | |
Cytomap | 1p36.31 | |
Gene Type | protein-coding | GO ID | GO:0000448 | UniProtAcc | Q5SY16 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79707 | NOL9 | LZE2T | Human | Esophagus | ESCC | 4.35e-02 | 5.05e-01 | 0.082 |
79707 | NOL9 | LZE7T | Human | Esophagus | ESCC | 1.27e-02 | 2.61e-01 | 0.0667 |
79707 | NOL9 | LZE22T | Human | Esophagus | ESCC | 3.89e-02 | 1.65e-01 | 0.068 |
79707 | NOL9 | LZE24T | Human | Esophagus | ESCC | 1.16e-12 | 1.62e-01 | 0.0596 |
79707 | NOL9 | P1T-E | Human | Esophagus | ESCC | 4.29e-02 | 1.47e-01 | 0.0875 |
79707 | NOL9 | P2T-E | Human | Esophagus | ESCC | 1.62e-31 | 4.71e-01 | 0.1177 |
79707 | NOL9 | P4T-E | Human | Esophagus | ESCC | 9.78e-21 | 4.56e-01 | 0.1323 |
79707 | NOL9 | P5T-E | Human | Esophagus | ESCC | 9.53e-15 | 2.28e-01 | 0.1327 |
79707 | NOL9 | P8T-E | Human | Esophagus | ESCC | 2.08e-14 | 1.48e-01 | 0.0889 |
79707 | NOL9 | P9T-E | Human | Esophagus | ESCC | 3.15e-04 | 8.52e-02 | 0.1131 |
79707 | NOL9 | P10T-E | Human | Esophagus | ESCC | 1.76e-16 | 3.20e-01 | 0.116 |
79707 | NOL9 | P11T-E | Human | Esophagus | ESCC | 1.43e-08 | 3.19e-01 | 0.1426 |
79707 | NOL9 | P12T-E | Human | Esophagus | ESCC | 9.32e-17 | 1.90e-01 | 0.1122 |
79707 | NOL9 | P15T-E | Human | Esophagus | ESCC | 3.40e-18 | 2.53e-01 | 0.1149 |
79707 | NOL9 | P16T-E | Human | Esophagus | ESCC | 1.95e-11 | 2.55e-01 | 0.1153 |
79707 | NOL9 | P19T-E | Human | Esophagus | ESCC | 8.49e-07 | 5.66e-01 | 0.1662 |
79707 | NOL9 | P20T-E | Human | Esophagus | ESCC | 2.06e-40 | 9.32e-01 | 0.1124 |
79707 | NOL9 | P21T-E | Human | Esophagus | ESCC | 2.02e-29 | 5.90e-01 | 0.1617 |
79707 | NOL9 | P22T-E | Human | Esophagus | ESCC | 1.36e-11 | 1.45e-01 | 0.1236 |
79707 | NOL9 | P23T-E | Human | Esophagus | ESCC | 1.61e-19 | 3.25e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042273111 | Esophagus | ESCC | ribosomal large subunit biogenesis | 65/8552 | 72/18723 | 1.53e-15 | 9.82e-14 | 65 |
GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:000047016 | Esophagus | ESCC | maturation of LSU-rRNA | 27/8552 | 28/18723 | 9.94e-09 | 2.00e-07 | 27 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00004603 | Esophagus | ESCC | maturation of 5.8S rRNA | 30/8552 | 35/18723 | 1.07e-06 | 1.34e-05 | 30 |
GO:00004693 | Esophagus | ESCC | cleavage involved in rRNA processing | 24/8552 | 27/18723 | 3.48e-06 | 3.84e-05 | 24 |
GO:00004634 | Esophagus | ESCC | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 15/8552 | 15/18723 | 7.81e-06 | 7.69e-05 | 15 |
GO:00004663 | Esophagus | ESCC | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 21/8552 | 24/18723 | 2.57e-05 | 2.17e-04 | 21 |
GO:00905023 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 55/8552 | 82/18723 | 7.34e-05 | 5.51e-04 | 55 |
GO:00004783 | Esophagus | ESCC | endonucleolytic cleavage involved in rRNA processing | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:00004793 | Esophagus | ESCC | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOL9 | SNV | Missense_Mutation | rs745497641 | c.626G>A | p.Arg209His | p.R209H | Q5SY16 | protein_coding | tolerated(0.54) | benign(0.117) | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD |
NOL9 | SNV | Missense_Mutation | rs200570941 | c.424N>A | p.Val142Met | p.V142M | Q5SY16 | protein_coding | tolerated(0.18) | benign(0.009) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NOL9 | SNV | Missense_Mutation | rs139109213 | c.625C>T | p.Arg209Cys | p.R209C | Q5SY16 | protein_coding | tolerated(0.22) | benign(0) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOL9 | SNV | Missense_Mutation | novel | c.1703N>G | p.His568Arg | p.H568R | Q5SY16 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOL9 | SNV | Missense_Mutation | c.967N>G | p.Leu323Val | p.L323V | Q5SY16 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NOL9 | SNV | Missense_Mutation | novel | c.865N>A | p.Val289Ile | p.V289I | Q5SY16 | protein_coding | tolerated(0.36) | benign(0.069) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOL9 | SNV | Missense_Mutation | novel | c.1925N>T | p.Ala642Val | p.A642V | Q5SY16 | protein_coding | tolerated(0.06) | possibly_damaging(0.643) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOL9 | SNV | Missense_Mutation | novel | c.922C>A | p.Gln308Lys | p.Q308K | Q5SY16 | protein_coding | tolerated(1) | benign(0.031) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
NOL9 | SNV | Missense_Mutation | rs139155763 | c.1666N>A | p.Ala556Thr | p.A556T | Q5SY16 | protein_coding | deleterious(0.04) | probably_damaging(0.985) | TCGA-55-8616-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOL9 | SNV | Missense_Mutation | novel | c.1783N>T | p.Ile595Phe | p.I595F | Q5SY16 | protein_coding | deleterious(0) | possibly_damaging(0.711) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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