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Gene: NOL8 |
Gene summary for NOL8 |
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Gene information | Species | Human | Gene symbol | NOL8 | Gene ID | 55035 |
Gene name | nucleolar protein 8 | |
Gene Alias | C9orf34 | |
Cytomap | 9q22.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A6H8Z4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55035 | NOL8 | LZE2T | Human | Esophagus | ESCC | 2.34e-04 | 3.37e-01 | 0.082 |
55035 | NOL8 | LZE4T | Human | Esophagus | ESCC | 1.37e-13 | 3.88e-01 | 0.0811 |
55035 | NOL8 | LZE7T | Human | Esophagus | ESCC | 8.23e-11 | 3.83e-01 | 0.0667 |
55035 | NOL8 | LZE8T | Human | Esophagus | ESCC | 1.37e-02 | 1.12e-01 | 0.067 |
55035 | NOL8 | LZE20T | Human | Esophagus | ESCC | 3.11e-03 | 9.75e-02 | 0.0662 |
55035 | NOL8 | LZE24T | Human | Esophagus | ESCC | 1.58e-09 | 2.46e-01 | 0.0596 |
55035 | NOL8 | LZE21T | Human | Esophagus | ESCC | 3.80e-04 | 1.99e-01 | 0.0655 |
55035 | NOL8 | P1T-E | Human | Esophagus | ESCC | 1.21e-03 | 1.81e-01 | 0.0875 |
55035 | NOL8 | P2T-E | Human | Esophagus | ESCC | 6.99e-37 | 5.50e-01 | 0.1177 |
55035 | NOL8 | P4T-E | Human | Esophagus | ESCC | 3.84e-20 | 5.07e-01 | 0.1323 |
55035 | NOL8 | P5T-E | Human | Esophagus | ESCC | 2.29e-16 | 2.67e-01 | 0.1327 |
55035 | NOL8 | P8T-E | Human | Esophagus | ESCC | 4.68e-14 | 2.11e-01 | 0.0889 |
55035 | NOL8 | P9T-E | Human | Esophagus | ESCC | 2.56e-13 | 3.13e-01 | 0.1131 |
55035 | NOL8 | P10T-E | Human | Esophagus | ESCC | 1.25e-32 | 4.84e-01 | 0.116 |
55035 | NOL8 | P11T-E | Human | Esophagus | ESCC | 3.75e-10 | 5.52e-01 | 0.1426 |
55035 | NOL8 | P12T-E | Human | Esophagus | ESCC | 6.62e-26 | 4.18e-01 | 0.1122 |
55035 | NOL8 | P15T-E | Human | Esophagus | ESCC | 8.05e-14 | 2.32e-01 | 0.1149 |
55035 | NOL8 | P16T-E | Human | Esophagus | ESCC | 1.59e-16 | 2.90e-01 | 0.1153 |
55035 | NOL8 | P17T-E | Human | Esophagus | ESCC | 1.71e-08 | 3.78e-01 | 0.1278 |
55035 | NOL8 | P19T-E | Human | Esophagus | ESCC | 6.59e-05 | 4.13e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:190257011 | Esophagus | ESCC | protein localization to nucleolus | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:003450421 | Liver | HCC | protein localization to nucleus | 194/7958 | 290/18723 | 2.84e-17 | 2.85e-15 | 194 |
GO:19025701 | Liver | HCC | protein localization to nucleolus | 13/7958 | 16/18723 | 1.84e-03 | 9.42e-03 | 13 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:000636410 | Oral cavity | OSCC | rRNA processing | 172/7305 | 225/18723 | 1.57e-30 | 1.24e-27 | 172 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOL8 | SNV | Missense_Mutation | novel | c.2131N>T | p.Arg711Trp | p.R711W | Q76FK4 | protein_coding | deleterious(0.02) | possibly_damaging(0.798) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NOL8 | SNV | Missense_Mutation | novel | c.794N>A | p.Ser265Tyr | p.S265Y | Q76FK4 | protein_coding | deleterious(0.04) | benign(0.36) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NOL8 | SNV | Missense_Mutation | rs374296577 | c.188N>T | p.Ala63Val | p.A63V | Q76FK4 | protein_coding | tolerated(0.06) | possibly_damaging(0.532) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NOL8 | SNV | Missense_Mutation | rs778480356 | c.124C>T | p.Arg42Trp | p.R42W | Q76FK4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0R8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NOL8 | SNV | Missense_Mutation | novel | c.667N>A | p.Val223Met | p.V223M | Q76FK4 | protein_coding | deleterious(0.04) | benign(0.034) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NOL8 | SNV | Missense_Mutation | novel | c.2214N>A | p.Phe738Leu | p.F738L | Q76FK4 | protein_coding | tolerated(0.43) | benign(0.003) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOL8 | SNV | Missense_Mutation | rs867066464 | c.1157C>T | p.Ala386Val | p.A386V | Q76FK4 | protein_coding | deleterious(0.01) | possibly_damaging(0.774) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOL8 | SNV | Missense_Mutation | rs772631824 | c.3112N>A | p.Ala1038Thr | p.A1038T | Q76FK4 | protein_coding | tolerated(0.28) | benign(0.006) | TCGA-AX-A064-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NOL8 | SNV | Missense_Mutation | rs138111378 | c.2639N>A | p.Arg880His | p.R880H | Q76FK4 | protein_coding | deleterious(0.03) | probably_damaging(0.981) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
NOL8 | SNV | Missense_Mutation | novel | c.451N>A | p.Pro151Thr | p.P151T | Q76FK4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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