|
Gene: NOL11 |
Gene summary for NOL11 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NOL11 | Gene ID | 25926 |
Gene name | nucleolar protein 11 | |
Gene Alias | NOL11 | |
Cytomap | 17q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9H8H0 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25926 | NOL11 | LZE4T | Human | Esophagus | ESCC | 1.88e-04 | 3.40e-01 | 0.0811 |
25926 | NOL11 | LZE7T | Human | Esophagus | ESCC | 1.81e-07 | 5.04e-01 | 0.0667 |
25926 | NOL11 | LZE20T | Human | Esophagus | ESCC | 1.03e-07 | 1.29e-01 | 0.0662 |
25926 | NOL11 | LZE22T | Human | Esophagus | ESCC | 2.12e-03 | 3.48e-01 | 0.068 |
25926 | NOL11 | LZE24T | Human | Esophagus | ESCC | 2.13e-13 | 3.31e-01 | 0.0596 |
25926 | NOL11 | LZE21T | Human | Esophagus | ESCC | 2.02e-02 | 2.66e-01 | 0.0655 |
25926 | NOL11 | LZE6T | Human | Esophagus | ESCC | 3.88e-04 | 1.54e-01 | 0.0845 |
25926 | NOL11 | P1T-E | Human | Esophagus | ESCC | 4.22e-03 | 3.05e-01 | 0.0875 |
25926 | NOL11 | P2T-E | Human | Esophagus | ESCC | 3.90e-27 | 5.55e-01 | 0.1177 |
25926 | NOL11 | P4T-E | Human | Esophagus | ESCC | 3.37e-12 | 3.71e-01 | 0.1323 |
25926 | NOL11 | P5T-E | Human | Esophagus | ESCC | 1.72e-26 | 6.91e-01 | 0.1327 |
25926 | NOL11 | P8T-E | Human | Esophagus | ESCC | 8.68e-20 | 3.88e-01 | 0.0889 |
25926 | NOL11 | P9T-E | Human | Esophagus | ESCC | 7.65e-11 | 2.54e-01 | 0.1131 |
25926 | NOL11 | P10T-E | Human | Esophagus | ESCC | 9.19e-28 | 4.52e-01 | 0.116 |
25926 | NOL11 | P11T-E | Human | Esophagus | ESCC | 3.00e-14 | 8.41e-01 | 0.1426 |
25926 | NOL11 | P12T-E | Human | Esophagus | ESCC | 4.48e-35 | 6.14e-01 | 0.1122 |
25926 | NOL11 | P15T-E | Human | Esophagus | ESCC | 2.20e-19 | 5.36e-01 | 0.1149 |
25926 | NOL11 | P16T-E | Human | Esophagus | ESCC | 5.25e-33 | 5.13e-01 | 0.1153 |
25926 | NOL11 | P17T-E | Human | Esophagus | ESCC | 2.34e-09 | 2.59e-01 | 0.1278 |
25926 | NOL11 | P20T-E | Human | Esophagus | ESCC | 8.95e-16 | 4.66e-01 | 0.1124 |
Page: 1 2 3 4 5 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042274111 | Esophagus | ESCC | ribosomal small subunit biogenesis | 67/8552 | 73/18723 | 6.62e-17 | 5.38e-15 | 67 |
GO:00304904 | Esophagus | ESCC | maturation of SSU-rRNA | 45/8552 | 50/18723 | 5.07e-11 | 1.63e-09 | 45 |
GO:00987812 | Esophagus | ESCC | ncRNA transcription | 45/8552 | 56/18723 | 1.05e-07 | 1.72e-06 | 45 |
GO:00063602 | Esophagus | ESCC | transcription by RNA polymerase I | 42/8552 | 55/18723 | 3.41e-06 | 3.78e-05 | 42 |
GO:00093032 | Esophagus | ESCC | rRNA transcription | 28/8552 | 34/18723 | 1.21e-05 | 1.12e-04 | 28 |
GO:00063564 | Esophagus | ESCC | regulation of transcription by RNA polymerase I | 27/8552 | 34/18723 | 6.01e-05 | 4.62e-04 | 27 |
GO:00459432 | Esophagus | ESCC | positive regulation of transcription by RNA polymerase I | 19/8552 | 23/18723 | 3.12e-04 | 1.85e-03 | 19 |
GO:00427902 | Esophagus | ESCC | nucleolar large rRNA transcription by RNA polymerase I | 15/8552 | 18/18723 | 1.20e-03 | 5.88e-03 | 15 |
GO:19018381 | Esophagus | ESCC | positive regulation of transcription of nucleolar large rRNA by RNA polymerase I | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:19018361 | Esophagus | ESCC | regulation of transcription of nucleolar large rRNA by RNA polymerase I | 12/8552 | 15/18723 | 7.31e-03 | 2.63e-02 | 12 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
Page: 1 2 3 4 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOL11 | SNV | Missense_Mutation | novel | c.1522T>G | p.Phe508Val | p.F508V | Q9H8H0 | protein_coding | deleterious(0) | possibly_damaging(0.554) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NOL11 | SNV | Missense_Mutation | novel | c.1521T>G | p.Ile507Met | p.I507M | Q9H8H0 | protein_coding | tolerated(0.11) | benign(0) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
NOL11 | SNV | Missense_Mutation | novel | c.878N>C | p.Lys293Thr | p.K293T | Q9H8H0 | protein_coding | tolerated(0.14) | benign(0.311) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NOL11 | SNV | Missense_Mutation | novel | c.103N>A | p.Leu35Ile | p.L35I | Q9H8H0 | protein_coding | tolerated(0.42) | probably_damaging(0.991) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NOL11 | SNV | Missense_Mutation | rs748697836 | c.2086N>T | p.Arg696Trp | p.R696W | Q9H8H0 | protein_coding | deleterious(0.03) | possibly_damaging(0.732) | TCGA-QS-A5YQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
NOL11 | insertion | Frame_Shift_Ins | novel | c.1262dupT | p.Leu421PhefsTer8 | p.L421Ffs*8 | Q9H8H0 | protein_coding | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NOL11 | SNV | Missense_Mutation | novel | c.2123N>C | p.Arg708Thr | p.R708T | Q9H8H0 | protein_coding | tolerated(0.81) | benign(0) | TCGA-55-7907-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NOL11 | SNV | Missense_Mutation | c.1907C>G | p.Pro636Arg | p.P636R | Q9H8H0 | protein_coding | tolerated(0.08) | probably_damaging(0.946) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
NOL11 | SNV | Missense_Mutation | c.292N>T | p.Asp98Tyr | p.D98Y | Q9H8H0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-8203-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NOL11 | SNV | Missense_Mutation | novel | c.43C>A | p.Leu15Met | p.L15M | Q9H8H0 | protein_coding | tolerated(0.06) | possibly_damaging(0.656) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |