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Gene: NACC1 |
Gene summary for NACC1 |
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Gene information | Species | Human | Gene symbol | NACC1 | Gene ID | 112939 |
Gene name | nucleus accumbens associated 1 | |
Gene Alias | BEND8 | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024R7E0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
112939 | NACC1 | LZE7T | Human | Esophagus | ESCC | 5.32e-07 | 3.69e-01 | 0.0667 |
112939 | NACC1 | LZE20T | Human | Esophagus | ESCC | 3.85e-02 | 1.19e-01 | 0.0662 |
112939 | NACC1 | P1T-E | Human | Esophagus | ESCC | 1.72e-03 | 2.67e-01 | 0.0875 |
112939 | NACC1 | P4T-E | Human | Esophagus | ESCC | 2.84e-04 | 1.11e-01 | 0.1323 |
112939 | NACC1 | P5T-E | Human | Esophagus | ESCC | 2.85e-07 | 9.08e-02 | 0.1327 |
112939 | NACC1 | P8T-E | Human | Esophagus | ESCC | 4.66e-07 | 1.93e-01 | 0.0889 |
112939 | NACC1 | P9T-E | Human | Esophagus | ESCC | 1.38e-05 | 1.30e-01 | 0.1131 |
112939 | NACC1 | P10T-E | Human | Esophagus | ESCC | 5.75e-07 | 1.76e-01 | 0.116 |
112939 | NACC1 | P12T-E | Human | Esophagus | ESCC | 1.65e-03 | 8.44e-02 | 0.1122 |
112939 | NACC1 | P15T-E | Human | Esophagus | ESCC | 6.56e-05 | 1.35e-01 | 0.1149 |
112939 | NACC1 | P21T-E | Human | Esophagus | ESCC | 1.22e-13 | 1.90e-01 | 0.1617 |
112939 | NACC1 | P22T-E | Human | Esophagus | ESCC | 9.97e-09 | 1.40e-01 | 0.1236 |
112939 | NACC1 | P23T-E | Human | Esophagus | ESCC | 7.68e-07 | 1.54e-01 | 0.108 |
112939 | NACC1 | P24T-E | Human | Esophagus | ESCC | 7.79e-07 | 7.03e-02 | 0.1287 |
112939 | NACC1 | P26T-E | Human | Esophagus | ESCC | 3.76e-06 | 1.06e-01 | 0.1276 |
112939 | NACC1 | P27T-E | Human | Esophagus | ESCC | 4.29e-03 | 8.93e-02 | 0.1055 |
112939 | NACC1 | P28T-E | Human | Esophagus | ESCC | 1.93e-17 | 3.45e-01 | 0.1149 |
112939 | NACC1 | P30T-E | Human | Esophagus | ESCC | 4.76e-07 | 1.96e-01 | 0.137 |
112939 | NACC1 | P31T-E | Human | Esophagus | ESCC | 1.43e-04 | 1.49e-01 | 0.1251 |
112939 | NACC1 | P32T-E | Human | Esophagus | ESCC | 1.81e-06 | 2.30e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NACC1 | SNV | Missense_Mutation | c.1262G>A | p.Arg421His | p.R421H | Q96RE7 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NACC1 | SNV | Missense_Mutation | novel | c.1079N>G | p.Tyr360Cys | p.Y360C | Q96RE7 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
NACC1 | SNV | Missense_Mutation | novel | c.1541N>T | p.Ser514Ile | p.S514I | Q96RE7 | protein_coding | tolerated_low_confidence(0.06) | benign(0.424) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD |
NACC1 | SNV | Missense_Mutation | c.1521N>T | p.Glu507Asp | p.E507D | Q96RE7 | protein_coding | tolerated_low_confidence(0.19) | benign(0.001) | TCGA-55-6712-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
NACC1 | SNV | Missense_Mutation | c.1522N>T | p.His508Tyr | p.H508Y | Q96RE7 | protein_coding | deleterious_low_confidence(0.01) | benign(0.044) | TCGA-55-6712-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
NACC1 | SNV | Missense_Mutation | rs778872897 | c.1165G>A | p.Val389Ile | p.V389I | Q96RE7 | protein_coding | tolerated(0.09) | benign(0.006) | TCGA-56-7730-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
NACC1 | SNV | Missense_Mutation | novel | c.290A>T | p.Gln97Leu | p.Q97L | Q96RE7 | protein_coding | tolerated(0.09) | probably_damaging(0.999) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NACC1 | SNV | Missense_Mutation | novel | c.1210G>C | p.Ala404Pro | p.A404P | Q96RE7 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-94-7033-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
NACC1 | deletion | Frame_Shift_Del | novel | c.125_126delNN | p.Lys42SerfsTer115 | p.K42Sfs*115 | Q96RE7 | protein_coding | TCGA-NK-A5CR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
NACC1 | SNV | Missense_Mutation | novel | c.1087G>T | p.Gly363Cys | p.G363C | Q96RE7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F7-7848-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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