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Gene: MZF1 |
Gene summary for MZF1 |
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Gene information | Species | Human | Gene symbol | MZF1 | Gene ID | 7593 |
Gene name | myeloid zinc finger 1 | |
Gene Alias | MZF-1 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P28698 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7593 | MZF1 | male-WTA | Human | Thyroid | PTC | 2.59e-08 | 7.30e-02 | 0.1037 |
7593 | MZF1 | PTC01 | Human | Thyroid | PTC | 2.44e-16 | 1.82e-01 | 0.1899 |
7593 | MZF1 | PTC03 | Human | Thyroid | PTC | 4.17e-03 | 1.61e-01 | 0.1784 |
7593 | MZF1 | PTC04 | Human | Thyroid | PTC | 4.22e-14 | 2.39e-01 | 0.1927 |
7593 | MZF1 | PTC05 | Human | Thyroid | PTC | 7.38e-21 | 5.34e-01 | 0.2065 |
7593 | MZF1 | PTC06 | Human | Thyroid | PTC | 4.53e-29 | 4.76e-01 | 0.2057 |
7593 | MZF1 | PTC07 | Human | Thyroid | PTC | 1.18e-19 | 3.59e-01 | 0.2044 |
7593 | MZF1 | ATC09 | Human | Thyroid | ATC | 1.24e-05 | 1.76e-01 | 0.2871 |
7593 | MZF1 | ATC12 | Human | Thyroid | ATC | 5.24e-05 | 5.57e-02 | 0.34 |
7593 | MZF1 | ATC13 | Human | Thyroid | ATC | 9.22e-17 | 1.39e-01 | 0.34 |
7593 | MZF1 | ATC1 | Human | Thyroid | ATC | 1.72e-06 | 2.11e-01 | 0.2878 |
7593 | MZF1 | ATC2 | Human | Thyroid | ATC | 2.98e-07 | 3.98e-01 | 0.34 |
7593 | MZF1 | ATC4 | Human | Thyroid | ATC | 1.03e-04 | 7.49e-02 | 0.34 |
7593 | MZF1 | ATC5 | Human | Thyroid | ATC | 8.69e-21 | 1.50e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MZF1 | SNV | Missense_Mutation | rs759875440 | c.221N>A | p.Arg74His | p.R74H | P28698 | protein_coding | deleterious(0.01) | possibly_damaging(0.542) | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD |
MZF1 | SNV | Missense_Mutation | novel | c.862N>T | p.Leu288Phe | p.L288F | P28698 | protein_coding | tolerated(0.07) | probably_damaging(0.921) | TCGA-B5-A11P-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MZF1 | SNV | Missense_Mutation | novel | c.415N>A | p.Gly139Ser | p.G139S | P28698 | protein_coding | tolerated(0.08) | benign(0.147) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MZF1 | SNV | Missense_Mutation | novel | c.1919N>C | p.Leu640Pro | p.L640P | P28698 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MZF1 | SNV | Missense_Mutation | novel | c.1216N>A | p.His406Asn | p.H406N | P28698 | protein_coding | deleterious(0) | possibly_damaging(0.613) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
MZF1 | SNV | Missense_Mutation | novel | c.1648N>G | p.Phe550Val | p.F550V | P28698 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
MZF1 | SNV | Missense_Mutation | novel | c.493C>T | p.Pro165Ser | p.P165S | P28698 | protein_coding | tolerated(0.34) | benign(0.003) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MZF1 | SNV | Missense_Mutation | novel | c.1724N>A | p.Gly575Asp | p.G575D | P28698 | protein_coding | deleterious(0) | probably_damaging(0.918) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MZF1 | SNV | Missense_Mutation | novel | c.451N>G | p.Ser151Gly | p.S151G | P28698 | protein_coding | tolerated(0.37) | benign(0) | TCGA-SL-A6JA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MZF1 | deletion | Frame_Shift_Del | novel | c.681delT | p.His229ThrfsTer35 | p.H229Tfs*35 | P28698 | protein_coding | TCGA-AP-A1DH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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