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Gene: MYCL |
Gene summary for MYCL |
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Gene information | Species | Human | Gene symbol | MYCL | Gene ID | 4610 |
Gene name | MYCL proto-oncogene, bHLH transcription factor | |
Gene Alias | L-Myc | |
Cytomap | 1p34.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P12524 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4610 | MYCL | LZE2T | Human | Esophagus | ESCC | 2.18e-04 | 5.91e-01 | 0.082 |
4610 | MYCL | LZE7T | Human | Esophagus | ESCC | 3.98e-06 | 2.50e-01 | 0.0667 |
4610 | MYCL | LZE20T | Human | Esophagus | ESCC | 4.88e-05 | 1.48e-01 | 0.0662 |
4610 | MYCL | LZE22T | Human | Esophagus | ESCC | 1.57e-02 | 2.64e-01 | 0.068 |
4610 | MYCL | LZE24T | Human | Esophagus | ESCC | 2.54e-14 | 8.04e-01 | 0.0596 |
4610 | MYCL | LZE21T | Human | Esophagus | ESCC | 8.02e-04 | 2.61e-01 | 0.0655 |
4610 | MYCL | P1T-E | Human | Esophagus | ESCC | 1.09e-04 | 2.61e-01 | 0.0875 |
4610 | MYCL | P4T-E | Human | Esophagus | ESCC | 1.26e-16 | 5.18e-01 | 0.1323 |
4610 | MYCL | P8T-E | Human | Esophagus | ESCC | 1.54e-05 | 2.10e-01 | 0.0889 |
4610 | MYCL | P9T-E | Human | Esophagus | ESCC | 1.65e-09 | 2.62e-01 | 0.1131 |
4610 | MYCL | P10T-E | Human | Esophagus | ESCC | 1.48e-104 | 1.88e+00 | 0.116 |
4610 | MYCL | P12T-E | Human | Esophagus | ESCC | 8.01e-22 | 5.22e-01 | 0.1122 |
4610 | MYCL | P15T-E | Human | Esophagus | ESCC | 5.96e-31 | 6.46e-01 | 0.1149 |
4610 | MYCL | P20T-E | Human | Esophagus | ESCC | 8.99e-31 | 5.87e-01 | 0.1124 |
4610 | MYCL | P21T-E | Human | Esophagus | ESCC | 3.09e-05 | 1.64e-01 | 0.1617 |
4610 | MYCL | P22T-E | Human | Esophagus | ESCC | 8.58e-07 | 2.83e-01 | 0.1236 |
4610 | MYCL | P23T-E | Human | Esophagus | ESCC | 7.44e-12 | 3.53e-01 | 0.108 |
4610 | MYCL | P26T-E | Human | Esophagus | ESCC | 2.03e-09 | 2.36e-01 | 0.1276 |
4610 | MYCL | P27T-E | Human | Esophagus | ESCC | 2.24e-21 | 5.82e-01 | 0.1055 |
4610 | MYCL | P28T-E | Human | Esophagus | ESCC | 9.82e-40 | 8.97e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000854410 | Esophagus | ESCC | epidermis development | 193/8552 | 324/18723 | 2.87e-07 | 4.19e-06 | 193 |
GO:000991310 | Esophagus | ESCC | epidermal cell differentiation | 122/8552 | 202/18723 | 1.69e-05 | 1.51e-04 | 122 |
GO:00456826 | Esophagus | ESCC | regulation of epidermis development | 46/8552 | 65/18723 | 3.65e-05 | 2.97e-04 | 46 |
GO:00456046 | Esophagus | ESCC | regulation of epidermal cell differentiation | 41/8552 | 58/18723 | 1.00e-04 | 7.10e-04 | 41 |
GO:00085449 | Oral cavity | OSCC | epidermis development | 171/7305 | 324/18723 | 2.89e-07 | 4.43e-06 | 171 |
GO:00099139 | Oral cavity | OSCC | epidermal cell differentiation | 109/7305 | 202/18723 | 1.08e-05 | 1.14e-04 | 109 |
GO:00456825 | Oral cavity | OSCC | regulation of epidermis development | 41/7305 | 65/18723 | 7.29e-05 | 5.73e-04 | 41 |
GO:00456045 | Oral cavity | OSCC | regulation of epidermal cell differentiation | 36/7305 | 58/18723 | 3.15e-04 | 1.96e-03 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYCL | SNV | Missense_Mutation | c.782N>T | p.Arg261Met | p.R261M | P12524 | protein_coding | tolerated(0.08) | possibly_damaging(0.692) | TCGA-05-4395-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MYCL | SNV | Missense_Mutation | novel | c.1124G>C | p.Arg375Thr | p.R375T | P12524 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-49-6742-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | alimta | PD |
MYCL | SNV | Missense_Mutation | novel | c.821N>T | p.Gly274Val | p.G274V | P12524 | protein_coding | tolerated(0.27) | benign(0.088) | TCGA-55-6979-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
MYCL | SNV | Missense_Mutation | rs778245654 | c.799G>A | p.Val267Ile | p.V267I | P12524 | protein_coding | tolerated(0.18) | benign(0.046) | TCGA-34-2596-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MYCL | SNV | Missense_Mutation | novel | c.734N>T | p.Ala245Val | p.A245V | P12524 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-60-2724-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD |
MYCL | SNV | Missense_Mutation | novel | c.338N>T | p.Gly113Val | p.G113V | P12524 | protein_coding | tolerated(0.29) | probably_damaging(0.98) | TCGA-CQ-6219-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
MYCL | SNV | Missense_Mutation | novel | c.746N>T | p.Pro249Leu | p.P249L | P12524 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-CV-A468-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MYCL | SNV | Missense_Mutation | novel | c.766N>C | p.Glu256Gln | p.E256Q | P12524 | protein_coding | tolerated(0.32) | possibly_damaging(0.579) | TCGA-MT-A51W-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MYCL | SNV | Missense_Mutation | rs767668202 | c.254N>T | p.Ala85Val | p.A85V | P12524 | protein_coding | tolerated(0.47) | benign(0.003) | TCGA-FP-8211-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | xeloda | CR |
MYCL | SNV | Missense_Mutation | rs748297163 | c.962N>A | p.Arg321His | p.R321H | P12524 | protein_coding | deleterious(0) | possibly_damaging(0.63) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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