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Gene: MYB |
Gene summary for MYB |
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Gene information | Species | Human | Gene symbol | MYB | Gene ID | 4602 |
Gene name | MYB proto-oncogene, transcription factor | |
Gene Alias | Cmyb | |
Cytomap | 6q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P10242 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4602 | MYB | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.28e-12 | -4.18e-01 | 0.0155 |
4602 | MYB | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.82e-04 | -4.60e-01 | -0.1808 |
4602 | MYB | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.87e-05 | -5.25e-01 | -0.1207 |
4602 | MYB | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.52e-03 | -3.00e-01 | 0.0674 |
4602 | MYB | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.87e-27 | -6.64e-01 | 0.3005 |
4602 | MYB | F007 | Human | Colorectum | FAP | 3.46e-04 | -3.43e-01 | 0.1176 |
4602 | MYB | A001-C-207 | Human | Colorectum | FAP | 3.60e-05 | -3.00e-01 | 0.1278 |
4602 | MYB | A015-C-203 | Human | Colorectum | FAP | 3.78e-28 | -3.53e-01 | -0.1294 |
4602 | MYB | A015-C-204 | Human | Colorectum | FAP | 3.61e-06 | -3.38e-01 | -0.0228 |
4602 | MYB | A014-C-040 | Human | Colorectum | FAP | 1.96e-03 | -3.15e-01 | -0.1184 |
4602 | MYB | A002-C-201 | Human | Colorectum | FAP | 1.45e-13 | -3.14e-01 | 0.0324 |
4602 | MYB | A002-C-203 | Human | Colorectum | FAP | 3.70e-07 | -2.86e-01 | 0.2786 |
4602 | MYB | A001-C-119 | Human | Colorectum | FAP | 1.38e-06 | -3.48e-01 | -0.1557 |
4602 | MYB | A001-C-108 | Human | Colorectum | FAP | 1.36e-17 | -3.39e-01 | -0.0272 |
4602 | MYB | A002-C-205 | Human | Colorectum | FAP | 4.88e-20 | -3.57e-01 | -0.1236 |
4602 | MYB | A001-C-104 | Human | Colorectum | FAP | 2.71e-08 | -2.79e-01 | 0.0184 |
4602 | MYB | A015-C-005 | Human | Colorectum | FAP | 9.20e-03 | -1.67e-01 | -0.0336 |
4602 | MYB | A015-C-006 | Human | Colorectum | FAP | 2.37e-16 | -4.75e-01 | -0.0994 |
4602 | MYB | A015-C-106 | Human | Colorectum | FAP | 4.39e-10 | -1.41e-01 | -0.0511 |
4602 | MYB | A002-C-114 | Human | Colorectum | FAP | 2.27e-17 | -3.41e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:0062197 | Colorectum | AD | cellular response to chemical stress | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0000302 | Colorectum | AD | response to reactive oxygen species | 78/3918 | 222/18723 | 6.17e-07 | 2.21e-05 | 78 |
GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
GO:0034599 | Colorectum | AD | cellular response to oxidative stress | 94/3918 | 288/18723 | 2.03e-06 | 6.02e-05 | 94 |
GO:1901214 | Colorectum | AD | regulation of neuron death | 99/3918 | 319/18723 | 1.26e-05 | 2.76e-04 | 99 |
GO:0042542 | Colorectum | AD | response to hydrogen peroxide | 52/3918 | 146/18723 | 2.83e-05 | 5.30e-04 | 52 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0051402 | Colorectum | AD | neuron apoptotic process | 77/3918 | 246/18723 | 8.07e-05 | 1.28e-03 | 77 |
GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
GO:0010720 | Colorectum | AD | positive regulation of cell development | 87/3918 | 298/18723 | 4.17e-04 | 4.71e-03 | 87 |
GO:0070482 | Colorectum | AD | response to oxygen levels | 99/3918 | 347/18723 | 4.29e-04 | 4.82e-03 | 99 |
GO:0034614 | Colorectum | AD | cellular response to reactive oxygen species | 50/3918 | 155/18723 | 6.25e-04 | 6.49e-03 | 50 |
GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
GO:0043523 | Colorectum | AD | regulation of neuron apoptotic process | 64/3918 | 212/18723 | 8.95e-04 | 8.63e-03 | 64 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0001666 | Colorectum | AD | response to hypoxia | 86/3918 | 307/18723 | 1.77e-03 | 1.46e-02 | 86 |
GO:0050767 | Colorectum | AD | regulation of neurogenesis | 99/3918 | 364/18723 | 2.35e-03 | 1.82e-02 | 99 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04151 | Colorectum | FAP | PI3K-Akt signaling pathway | 75/1404 | 354/8465 | 1.23e-02 | 4.19e-02 | 2.55e-02 | 75 |
hsa041511 | Colorectum | FAP | PI3K-Akt signaling pathway | 75/1404 | 354/8465 | 1.23e-02 | 4.19e-02 | 2.55e-02 | 75 |
hsa041512 | Colorectum | CRC | PI3K-Akt signaling pathway | 64/1091 | 354/8465 | 2.70e-03 | 1.77e-02 | 1.20e-02 | 64 |
hsa041513 | Colorectum | CRC | PI3K-Akt signaling pathway | 64/1091 | 354/8465 | 2.70e-03 | 1.77e-02 | 1.20e-02 | 64 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYB | SNV | Missense_Mutation | c.1418G>T | p.Ser473Ile | p.S473I | P10242 | protein_coding | deleterious(0) | benign(0.316) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MYB | SNV | Missense_Mutation | novel | c.1361G>A | p.Arg454His | p.R454H | P10242 | protein_coding | tolerated(0.56) | benign(0.172) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
MYB | SNV | Missense_Mutation | novel | c.580G>A | p.Glu194Lys | p.E194K | P10242 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
MYB | SNV | Missense_Mutation | c.2155N>T | p.Ala719Ser | p.A719S | P10242 | protein_coding | tolerated(0.68) | benign(0.157) | TCGA-B5-A0K6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MYB | SNV | Missense_Mutation | novel | c.125G>T | p.Arg42Met | p.R42M | P10242 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
MYB | SNV | Missense_Mutation | novel | c.660N>T | p.Leu220Phe | p.L220F | P10242 | protein_coding | tolerated(0.09) | benign(0.081) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MYB | SNV | Missense_Mutation | c.769N>G | p.Ser257Gly | p.S257G | P10242 | protein_coding | tolerated(0.65) | benign(0.001) | TCGA-BS-A0UA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MYB | SNV | Missense_Mutation | rs770846525 | c.1242N>A | p.Phe414Leu | p.F414L | P10242 | protein_coding | tolerated(1) | benign(0.005) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MYB | SNV | Missense_Mutation | rs770846525 | c.1242N>A | p.Phe414Leu | p.F414L | P10242 | protein_coding | tolerated(1) | benign(0.005) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MYB | SNV | Missense_Mutation | c.2068N>A | p.Leu690Ile | p.L690I | P10242 | protein_coding | deleterious(0.03) | benign(0.056) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4602 | MYB | CLINICALLY ACTIONABLE | RETINOID | 8670250 | ||
4602 | MYB | CLINICALLY ACTIONABLE | 12-O-TETRADECANOYLPHORBOL-13-ACETATE | 12354938 | ||
4602 | MYB | CLINICALLY ACTIONABLE | 5-FLUOROURACIL | FLUOROURACIL | 15001837 | |
4602 | MYB | CLINICALLY ACTIONABLE | DOXORUBICIN | DOXORUBICIN | 15001837 | |
4602 | MYB | CLINICALLY ACTIONABLE | G4460 | |||
4602 | MYB | CLINICALLY ACTIONABLE | TAXOL | PACLITAXEL | 15001837 |
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