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Gene: MTMR14 |
Gene summary for MTMR14 |
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Gene information | Species | Human | Gene symbol | MTMR14 | Gene ID | 64419 |
Gene name | myotubularin related protein 14 | |
Gene Alias | C3orf29 | |
Cytomap | 3p25.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8NCE2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64419 | MTMR14 | LZE7T | Human | Esophagus | ESCC | 1.98e-02 | 6.74e-02 | 0.0667 |
64419 | MTMR14 | LZE22T | Human | Esophagus | ESCC | 1.04e-03 | 2.17e-01 | 0.068 |
64419 | MTMR14 | LZE24T | Human | Esophagus | ESCC | 1.00e-12 | 3.24e-01 | 0.0596 |
64419 | MTMR14 | P2T-E | Human | Esophagus | ESCC | 8.92e-11 | 1.44e-01 | 0.1177 |
64419 | MTMR14 | P4T-E | Human | Esophagus | ESCC | 6.41e-09 | 1.88e-01 | 0.1323 |
64419 | MTMR14 | P5T-E | Human | Esophagus | ESCC | 1.45e-17 | 2.88e-01 | 0.1327 |
64419 | MTMR14 | P8T-E | Human | Esophagus | ESCC | 1.04e-16 | 1.72e-01 | 0.0889 |
64419 | MTMR14 | P9T-E | Human | Esophagus | ESCC | 6.14e-03 | 1.24e-01 | 0.1131 |
64419 | MTMR14 | P10T-E | Human | Esophagus | ESCC | 9.13e-16 | 2.49e-01 | 0.116 |
64419 | MTMR14 | P11T-E | Human | Esophagus | ESCC | 2.12e-12 | 5.83e-01 | 0.1426 |
64419 | MTMR14 | P12T-E | Human | Esophagus | ESCC | 4.36e-08 | 3.78e-01 | 0.1122 |
64419 | MTMR14 | P15T-E | Human | Esophagus | ESCC | 6.29e-07 | 1.83e-01 | 0.1149 |
64419 | MTMR14 | P16T-E | Human | Esophagus | ESCC | 1.15e-15 | 1.58e-01 | 0.1153 |
64419 | MTMR14 | P17T-E | Human | Esophagus | ESCC | 5.82e-07 | 2.96e-01 | 0.1278 |
64419 | MTMR14 | P19T-E | Human | Esophagus | ESCC | 3.67e-06 | 5.33e-01 | 0.1662 |
64419 | MTMR14 | P20T-E | Human | Esophagus | ESCC | 1.55e-12 | 2.39e-01 | 0.1124 |
64419 | MTMR14 | P21T-E | Human | Esophagus | ESCC | 1.95e-22 | 3.55e-01 | 0.1617 |
64419 | MTMR14 | P22T-E | Human | Esophagus | ESCC | 1.98e-03 | 2.00e-02 | 0.1236 |
64419 | MTMR14 | P23T-E | Human | Esophagus | ESCC | 2.22e-23 | 5.51e-01 | 0.108 |
64419 | MTMR14 | P24T-E | Human | Esophagus | ESCC | 2.89e-18 | 3.88e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:00464744 | Esophagus | ESCC | glycerophospholipid biosynthetic process | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:00450175 | Esophagus | ESCC | glycerolipid biosynthetic process | 154/8552 | 252/18723 | 5.20e-07 | 6.96e-06 | 154 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:00066505 | Esophagus | ESCC | glycerophospholipid metabolic process | 174/8552 | 306/18723 | 4.92e-05 | 3.85e-04 | 174 |
GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
GO:00066611 | Esophagus | ESCC | phosphatidylinositol biosynthetic process | 73/8552 | 131/18723 | 1.31e-02 | 4.28e-02 | 73 |
GO:001623621 | Liver | HCC | macroautophagy | 204/7958 | 291/18723 | 8.66e-22 | 1.41e-19 | 204 |
GO:00086542 | Liver | HCC | phospholipid biosynthetic process | 150/7958 | 253/18723 | 4.77e-08 | 1.03e-06 | 150 |
GO:00066444 | Liver | HCC | phospholipid metabolic process | 214/7958 | 383/18723 | 7.25e-08 | 1.48e-06 | 214 |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
GO:000647021 | Liver | HCC | protein dephosphorylation | 162/7958 | 281/18723 | 1.91e-07 | 3.46e-06 | 162 |
GO:004648611 | Liver | HCC | glycerolipid metabolic process | 215/7958 | 392/18723 | 4.54e-07 | 7.49e-06 | 215 |
GO:004501711 | Liver | HCC | glycerolipid biosynthetic process | 143/7958 | 252/18723 | 3.27e-06 | 4.31e-05 | 143 |
GO:00066504 | Liver | HCC | glycerophospholipid metabolic process | 168/7958 | 306/18723 | 7.27e-06 | 8.62e-05 | 168 |
GO:004647411 | Liver | HCC | glycerophospholipid biosynthetic process | 121/7958 | 211/18723 | 9.12e-06 | 1.06e-04 | 121 |
GO:0006661 | Liver | HCC | phosphatidylinositol biosynthetic process | 69/7958 | 131/18723 | 1.19e-02 | 4.35e-02 | 69 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414010 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0414015 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0414021 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa0414031 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa041409 | Oral cavity | OSCC | Autophagy - animal | 94/3704 | 141/8465 | 2.73e-08 | 2.38e-07 | 1.21e-07 | 94 |
hsa0414014 | Oral cavity | OSCC | Autophagy - animal | 94/3704 | 141/8465 | 2.73e-08 | 2.38e-07 | 1.21e-07 | 94 |
hsa0414041 | Oral cavity | EOLP | Autophagy - animal | 39/1218 | 141/8465 | 2.68e-05 | 1.38e-04 | 8.12e-05 | 39 |
hsa0414051 | Oral cavity | EOLP | Autophagy - animal | 39/1218 | 141/8465 | 2.68e-05 | 1.38e-04 | 8.12e-05 | 39 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTMR14 | SNV | Missense_Mutation | novel | c.323T>C | p.Val108Ala | p.V108A | Q8NCE2 | protein_coding | tolerated(0.19) | benign(0.109) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MTMR14 | SNV | Missense_Mutation | novel | c.1588N>T | p.Ser530Cys | p.S530C | Q8NCE2 | protein_coding | deleterious(0) | possibly_damaging(0.887) | TCGA-ZG-A9ND-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
MTMR14 | SNV | Missense_Mutation | c.682N>G | p.Thr228Ala | p.T228A | Q8NCE2 | protein_coding | deleterious(0) | benign(0.15) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MTMR14 | SNV | Missense_Mutation | novel | c.541G>C | p.Asp181His | p.D181H | Q8NCE2 | protein_coding | deleterious(0.01) | possibly_damaging(0.79) | TCGA-BR-8060-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MTMR14 | SNV | Missense_Mutation | c.166N>T | p.Arg56Cys | p.R56C | Q8NCE2 | protein_coding | tolerated(0.06) | benign(0.183) | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR | |
MTMR14 | SNV | Missense_Mutation | novel | c.1582G>A | p.Gly528Ser | p.G528S | Q8NCE2 | protein_coding | tolerated(0.33) | probably_damaging(0.998) | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
MTMR14 | SNV | Missense_Mutation | novel | c.902G>T | p.Trp301Leu | p.W301L | Q8NCE2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BJ-A191-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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