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Gene: MS4A7 |
Gene summary for MS4A7 |
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Gene information | Species | Human | Gene symbol | MS4A7 | Gene ID | 58475 |
Gene name | membrane spanning 4-domains A7 | |
Gene Alias | 4SPAN2 | |
Cytomap | 11q12.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R556 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
58475 | MS4A7 | GSM4909297 | Human | Breast | IDC | 2.09e-14 | 5.32e-01 | 0.1517 |
58475 | MS4A7 | GSM4909298 | Human | Breast | IDC | 5.92e-20 | 4.80e-01 | 0.1551 |
58475 | MS4A7 | GSM4909302 | Human | Breast | IDC | 4.99e-50 | 1.06e+00 | 0.1545 |
58475 | MS4A7 | GSM4909304 | Human | Breast | IDC | 2.21e-48 | 8.32e-01 | 0.1636 |
58475 | MS4A7 | GSM4909306 | Human | Breast | IDC | 8.01e-16 | 4.10e-01 | 0.1564 |
58475 | MS4A7 | M5 | Human | Breast | IDC | 3.93e-17 | 1.10e+00 | 0.1598 |
58475 | MS4A7 | NCCBC14 | Human | Breast | DCIS | 4.76e-03 | 3.24e-01 | 0.2021 |
58475 | MS4A7 | NCCBC3 | Human | Breast | DCIS | 2.31e-08 | 4.21e-01 | 0.1198 |
58475 | MS4A7 | cirrhotic2 | Human | Liver | Cirrhotic | 1.75e-03 | -2.80e-02 | 0.0201 |
58475 | MS4A7 | HCC2 | Human | Liver | HCC | 7.40e-07 | 8.43e-01 | 0.5341 |
58475 | MS4A7 | Pt13.a | Human | Liver | HCC | 5.26e-16 | 5.73e-01 | 0.021 |
58475 | MS4A7 | Pt13.c | Human | Liver | HCC | 2.52e-08 | 6.45e-01 | 0.0076 |
58475 | MS4A7 | Pt14.d | Human | Liver | HCC | 1.32e-24 | 7.67e-01 | 0.0143 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MS4A7 | SNV | Missense_Mutation | novel | c.479C>T | p.Pro160Leu | p.P160L | Q9GZW8 | protein_coding | tolerated(0.08) | probably_damaging(0.99) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
MS4A7 | SNV | Missense_Mutation | novel | c.332N>G | p.Lys111Arg | p.K111R | Q9GZW8 | protein_coding | deleterious(0.04) | possibly_damaging(0.82) | TCGA-O2-A52S-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
MS4A7 | SNV | Missense_Mutation | novel | c.382N>A | p.Ala128Thr | p.A128T | Q9GZW8 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-CR-7379-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MS4A7 | SNV | Missense_Mutation | novel | c.179C>T | p.Ser60Leu | p.S60L | Q9GZW8 | protein_coding | tolerated(1) | possibly_damaging(0.77) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MS4A7 | SNV | Missense_Mutation | c.710N>A | p.Arg237Gln | p.R237Q | Q9GZW8 | protein_coding | deleterious_low_confidence(0.02) | benign(0) | TCGA-D6-6826-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MS4A7 | SNV | Missense_Mutation | novel | c.34N>G | p.His12Asp | p.H12D | Q9GZW8 | protein_coding | tolerated(0.86) | benign(0) | TCGA-TN-A7HL-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
MS4A7 | SNV | Missense_Mutation | c.374N>A | p.Ser125Tyr | p.S125Y | Q9GZW8 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
MS4A7 | SNV | Missense_Mutation | c.523N>T | p.Leu175Phe | p.L175F | Q9GZW8 | protein_coding | tolerated(0.39) | benign(0.054) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
MS4A7 | deletion | Frame_Shift_Del | novel | c.318delN | p.Lys107AsnfsTer9 | p.K107Nfs*9 | Q9GZW8 | protein_coding | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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