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Gene: MORF4L1 |
Gene summary for MORF4L1 |
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Gene information | Species | Human | Gene symbol | MORF4L1 | Gene ID | 10933 |
Gene name | mortality factor 4 like 1 | |
Gene Alias | Eaf3 | |
Cytomap | 15q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000724 | UniProtAcc | Q9UBU8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10933 | MORF4L1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.18e-02 | 5.20e-01 | -0.0811 |
10933 | MORF4L1 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.12e-04 | 4.50e-01 | -0.1088 |
10933 | MORF4L1 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.09e-11 | 5.99e-01 | -0.1954 |
10933 | MORF4L1 | HTA11_411_2000001011 | Human | Colorectum | SER | 8.03e-06 | 9.06e-01 | -0.2602 |
10933 | MORF4L1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.13e-03 | 3.44e-01 | -0.1464 |
10933 | MORF4L1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.66e-04 | 4.88e-01 | -0.059 |
10933 | MORF4L1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.76e-05 | 4.00e-01 | 0.096 |
10933 | MORF4L1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.56e-19 | 8.20e-01 | 0.294 |
10933 | MORF4L1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 3.50e-04 | 1.12e+00 | 0.3487 |
10933 | MORF4L1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.17e-04 | 5.82e-01 | 0.281 |
10933 | MORF4L1 | A015-C-203 | Human | Colorectum | FAP | 4.10e-05 | -9.43e-02 | -0.1294 |
10933 | MORF4L1 | A002-C-201 | Human | Colorectum | FAP | 2.25e-02 | -1.06e-01 | 0.0324 |
10933 | MORF4L1 | A002-C-205 | Human | Colorectum | FAP | 1.44e-05 | -1.59e-01 | -0.1236 |
10933 | MORF4L1 | A015-C-006 | Human | Colorectum | FAP | 3.18e-02 | -8.70e-02 | -0.0994 |
10933 | MORF4L1 | A002-C-114 | Human | Colorectum | FAP | 8.87e-04 | -7.22e-02 | -0.1561 |
10933 | MORF4L1 | A015-C-104 | Human | Colorectum | FAP | 1.11e-05 | -1.58e-01 | -0.1899 |
10933 | MORF4L1 | A002-C-016 | Human | Colorectum | FAP | 6.03e-03 | -7.31e-02 | 0.0521 |
10933 | MORF4L1 | A002-C-116 | Human | Colorectum | FAP | 1.35e-05 | -6.68e-02 | -0.0452 |
10933 | MORF4L1 | A014-C-008 | Human | Colorectum | FAP | 4.87e-03 | -1.82e-01 | -0.191 |
10933 | MORF4L1 | A018-E-020 | Human | Colorectum | FAP | 6.33e-03 | -8.43e-02 | -0.2034 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016570 | Colorectum | MSS | histone modification | 113/3467 | 463/18723 | 8.37e-04 | 8.68e-03 | 113 |
GO:0006302 | Colorectum | MSS | double-strand break repair | 64/3467 | 251/18723 | 3.58e-03 | 2.65e-02 | 64 |
GO:00165701 | Colorectum | FAP | histone modification | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:001839413 | Esophagus | ESCC | peptidyl-lysine acetylation | 123/8552 | 169/18723 | 6.58e-13 | 2.94e-11 | 123 |
GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
GO:000647313 | Esophagus | ESCC | protein acetylation | 140/8552 | 201/18723 | 4.37e-12 | 1.69e-10 | 140 |
GO:001839313 | Esophagus | ESCC | internal peptidyl-lysine acetylation | 114/8552 | 158/18723 | 1.16e-11 | 4.24e-10 | 114 |
GO:000647513 | Esophagus | ESCC | internal protein amino acid acetylation | 115/8552 | 160/18723 | 1.43e-11 | 5.08e-10 | 115 |
GO:00165735 | Esophagus | ESCC | histone acetylation | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:004396712 | Esophagus | ESCC | histone H4 acetylation | 53/8552 | 67/18723 | 2.11e-08 | 4.03e-07 | 53 |
GO:00356015 | Esophagus | ESCC | protein deacylation | 79/8552 | 112/18723 | 8.30e-08 | 1.42e-06 | 79 |
GO:00987325 | Esophagus | ESCC | macromolecule deacylation | 80/8552 | 116/18723 | 3.19e-07 | 4.50e-06 | 80 |
GO:00165754 | Esophagus | ESCC | histone deacetylation | 60/8552 | 82/18723 | 3.85e-07 | 5.32e-06 | 60 |
GO:00064765 | Esophagus | ESCC | protein deacetylation | 70/8552 | 101/18723 | 1.29e-06 | 1.58e-05 | 70 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:00439682 | Esophagus | ESCC | histone H2A acetylation | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:00007241 | Esophagus | ESCC | double-strand break repair via homologous recombination | 79/8552 | 138/18723 | 4.05e-03 | 1.62e-02 | 79 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MORF4L1 | SNV | Missense_Mutation | novel | c.130N>G | p.Ile44Val | p.I44V | Q9UBU8 | protein_coding | tolerated(0.27) | benign(0.277) | TCGA-CR-6474-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | PD | |
MORF4L1 | SNV | Missense_Mutation | c.152N>C | p.Lys51Thr | p.K51T | Q9UBU8 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
MORF4L1 | SNV | Missense_Mutation | c.1045G>A | p.Asp349Asn | p.D349N | Q9UBU8 | protein_coding | tolerated(0.08) | benign(0.245) | TCGA-CD-A4MI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
MORF4L1 | SNV | Missense_Mutation | novel | c.302T>A | p.Val101Glu | p.V101E | Q9UBU8 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-IN-A7NT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | leucovorin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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