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Gene: MMP10 |
Gene summary for MMP10 |
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Gene information | Species | Human | Gene symbol | MMP10 | Gene ID | 4319 |
Gene name | matrix metallopeptidase 10 | |
Gene Alias | SL-2 | |
Cytomap | 11q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P09238 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4319 | MMP10 | Tumor | Human | Cervix | CC | 2.09e-07 | 3.86e-01 | 0.1241 |
4319 | MMP10 | sample3 | Human | Cervix | CC | 3.17e-17 | 5.62e-01 | 0.1387 |
4319 | MMP10 | T3 | Human | Cervix | CC | 1.12e-12 | 5.20e-01 | 0.1389 |
4319 | MMP10 | LZE8T | Human | Esophagus | ESCC | 8.46e-25 | 3.27e+00 | 0.067 |
4319 | MMP10 | P2T-E | Human | Esophagus | ESCC | 6.83e-07 | -1.01e-01 | 0.1177 |
4319 | MMP10 | P8T-E | Human | Esophagus | ESCC | 3.87e-32 | 2.95e+00 | 0.0889 |
4319 | MMP10 | P11T-E | Human | Esophagus | ESCC | 8.73e-06 | 2.92e+00 | 0.1426 |
4319 | MMP10 | P26T-E | Human | Esophagus | ESCC | 5.62e-35 | 3.23e+00 | 0.1276 |
4319 | MMP10 | P31T-E | Human | Esophagus | ESCC | 2.05e-05 | 1.34e+00 | 0.1251 |
4319 | MMP10 | P37T-E | Human | Esophagus | ESCC | 9.84e-23 | 1.62e+00 | 0.1371 |
4319 | MMP10 | P54T-E | Human | Esophagus | ESCC | 3.18e-08 | 1.89e+00 | 0.0975 |
4319 | MMP10 | P61T-E | Human | Esophagus | ESCC | 3.81e-14 | 1.49e+00 | 0.099 |
4319 | MMP10 | P62T-E | Human | Esophagus | ESCC | 5.45e-04 | 1.86e+00 | 0.1302 |
4319 | MMP10 | P65T-E | Human | Esophagus | ESCC | 2.53e-07 | 9.40e-01 | 0.0978 |
4319 | MMP10 | P74T-E | Human | Esophagus | ESCC | 4.87e-24 | 3.58e+00 | 0.1479 |
4319 | MMP10 | P83T-E | Human | Esophagus | ESCC | 6.63e-04 | 1.11e+00 | 0.1738 |
4319 | MMP10 | P89T-E | Human | Esophagus | ESCC | 4.07e-11 | 4.89e+00 | 0.1752 |
4319 | MMP10 | P107T-E | Human | Esophagus | ESCC | 5.33e-49 | 4.41e+00 | 0.171 |
4319 | MMP10 | P126T-E | Human | Esophagus | ESCC | 2.43e-05 | 2.74e+00 | 0.1125 |
4319 | MMP10 | P130T-E | Human | Esophagus | ESCC | 1.72e-15 | 1.40e+00 | 0.1676 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002241110 | Cervix | CC | cellular component disassembly | 83/2311 | 443/18723 | 6.04e-05 | 8.68e-04 | 83 |
GO:0030198 | Cervix | CC | extracellular matrix organization | 52/2311 | 301/18723 | 7.43e-03 | 3.98e-02 | 52 |
GO:0043062 | Cervix | CC | extracellular structure organization | 52/2311 | 302/18723 | 7.92e-03 | 4.17e-02 | 52 |
GO:0022617 | Cervix | CC | extracellular matrix disassembly | 15/2311 | 63/18723 | 8.52e-03 | 4.40e-02 | 15 |
GO:0045229 | Cervix | CC | external encapsulating structure organization | 52/2311 | 304/18723 | 9.00e-03 | 4.57e-02 | 52 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:00301984 | Esophagus | ESCC | extracellular matrix organization | 171/8552 | 301/18723 | 6.08e-05 | 4.67e-04 | 171 |
GO:00430624 | Esophagus | ESCC | extracellular structure organization | 171/8552 | 302/18723 | 7.73e-05 | 5.76e-04 | 171 |
GO:00452294 | Esophagus | ESCC | external encapsulating structure organization | 172/8552 | 304/18723 | 7.80e-05 | 5.80e-04 | 172 |
GO:00329631 | Esophagus | ESCC | collagen metabolic process | 62/8552 | 104/18723 | 2.90e-03 | 1.22e-02 | 62 |
GO:00226172 | Esophagus | ESCC | extracellular matrix disassembly | 39/8552 | 63/18723 | 6.92e-03 | 2.52e-02 | 39 |
GO:002241119 | Oral cavity | OSCC | cellular component disassembly | 283/7305 | 443/18723 | 9.57e-27 | 3.37e-24 | 283 |
GO:00301983 | Oral cavity | OSCC | extracellular matrix organization | 146/7305 | 301/18723 | 4.67e-04 | 2.77e-03 | 146 |
GO:00452293 | Oral cavity | OSCC | external encapsulating structure organization | 147/7305 | 304/18723 | 5.30e-04 | 3.08e-03 | 147 |
GO:00430623 | Oral cavity | OSCC | extracellular structure organization | 146/7305 | 302/18723 | 5.59e-04 | 3.23e-03 | 146 |
GO:00226171 | Oral cavity | OSCC | extracellular matrix disassembly | 37/7305 | 63/18723 | 1.18e-03 | 5.99e-03 | 37 |
GO:0032963 | Oral cavity | OSCC | collagen metabolic process | 54/7305 | 104/18723 | 5.00e-03 | 1.96e-02 | 54 |
GO:002241117 | Prostate | BPH | cellular component disassembly | 121/3107 | 443/18723 | 6.34e-09 | 2.25e-07 | 121 |
GO:00430621 | Prostate | BPH | extracellular structure organization | 67/3107 | 302/18723 | 6.67e-03 | 3.00e-02 | 67 |
GO:00301981 | Prostate | BPH | extracellular matrix organization | 66/3107 | 301/18723 | 9.20e-03 | 3.92e-02 | 66 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MMP10 | SNV | Missense_Mutation | novel | c.395N>T | p.Ala132Val | p.A132V | P09238 | protein_coding | deleterious(0.02) | possibly_damaging(0.662) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MMP10 | SNV | Missense_Mutation | novel | c.1165G>C | p.Ala389Pro | p.A389P | P09238 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MMP10 | SNV | Missense_Mutation | c.107N>G | p.Gln36Arg | p.Q36R | P09238 | protein_coding | tolerated(0.08) | benign(0.183) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MMP10 | insertion | Frame_Shift_Ins | rs746110396 | c.187_188insA | p.Ile63AsnfsTer19 | p.I63Nfs*19 | P09238 | protein_coding | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD | ||
MMP10 | SNV | Missense_Mutation | novel | c.1361A>T | p.Gln454Leu | p.Q454L | P09238 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-DD-AAEE-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
MMP10 | SNV | Missense_Mutation | novel | c.1088G>T | p.Arg363Ile | p.R363I | P09238 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
MMP10 | SNV | Missense_Mutation | novel | c.515N>T | p.Ser172Phe | p.S172F | P09238 | protein_coding | deleterious(0.01) | possibly_damaging(0.846) | TCGA-50-5049-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MMP10 | SNV | Missense_Mutation | c.574N>A | p.Gly192Arg | p.G192R | P09238 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-55-8085-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MMP10 | SNV | Missense_Mutation | c.791N>A | p.Pro264His | p.P264H | P09238 | protein_coding | deleterious(0.01) | benign(0.176) | TCGA-64-5778-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Targeted Molecular therapy | tarceva | PD | |
MMP10 | SNV | Missense_Mutation | novel | c.820G>T | p.Val274Leu | p.V274L | P09238 | protein_coding | tolerated(0.35) | benign(0.15) | TCGA-69-7974-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4319 | MMP10 | DRUGGABLE GENOME, ENZYME, PROTEASE | inhibitor | 249565939 |
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