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Gene: METTL22 |
Gene summary for METTL22 |
Gene summary. |
Gene information | Species | Human | Gene symbol | METTL22 | Gene ID | 79091 |
Gene name | methyltransferase 22, Kin17 lysine | |
Gene Alias | C16orf68 | |
Cytomap | 16p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9BUU2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79091 | METTL22 | LZE4T | Human | Esophagus | ESCC | 1.59e-04 | 1.22e-01 | 0.0811 |
79091 | METTL22 | LZE7T | Human | Esophagus | ESCC | 1.49e-05 | 2.54e-01 | 0.0667 |
79091 | METTL22 | LZE8T | Human | Esophagus | ESCC | 2.30e-03 | 1.15e-01 | 0.067 |
79091 | METTL22 | LZE24T | Human | Esophagus | ESCC | 8.92e-09 | 1.83e-01 | 0.0596 |
79091 | METTL22 | LZE6T | Human | Esophagus | ESCC | 4.91e-02 | 1.42e-01 | 0.0845 |
79091 | METTL22 | P1T-E | Human | Esophagus | ESCC | 4.53e-07 | 2.66e-01 | 0.0875 |
79091 | METTL22 | P2T-E | Human | Esophagus | ESCC | 6.38e-24 | 4.14e-01 | 0.1177 |
79091 | METTL22 | P4T-E | Human | Esophagus | ESCC | 1.37e-10 | 2.37e-01 | 0.1323 |
79091 | METTL22 | P5T-E | Human | Esophagus | ESCC | 4.94e-08 | 1.30e-01 | 0.1327 |
79091 | METTL22 | P8T-E | Human | Esophagus | ESCC | 1.02e-11 | 2.66e-01 | 0.0889 |
79091 | METTL22 | P9T-E | Human | Esophagus | ESCC | 1.01e-03 | 1.33e-01 | 0.1131 |
79091 | METTL22 | P10T-E | Human | Esophagus | ESCC | 1.51e-10 | 1.87e-01 | 0.116 |
79091 | METTL22 | P11T-E | Human | Esophagus | ESCC | 1.82e-04 | 2.22e-01 | 0.1426 |
79091 | METTL22 | P12T-E | Human | Esophagus | ESCC | 8.74e-17 | 3.06e-01 | 0.1122 |
79091 | METTL22 | P15T-E | Human | Esophagus | ESCC | 1.88e-16 | 3.01e-01 | 0.1149 |
79091 | METTL22 | P16T-E | Human | Esophagus | ESCC | 3.06e-21 | 3.25e-01 | 0.1153 |
79091 | METTL22 | P17T-E | Human | Esophagus | ESCC | 5.87e-03 | 1.61e-01 | 0.1278 |
79091 | METTL22 | P20T-E | Human | Esophagus | ESCC | 1.64e-10 | 2.61e-01 | 0.1124 |
79091 | METTL22 | P21T-E | Human | Esophagus | ESCC | 4.89e-16 | 1.82e-01 | 0.1617 |
79091 | METTL22 | P22T-E | Human | Esophagus | ESCC | 3.98e-17 | 3.49e-01 | 0.1236 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:000647914 | Esophagus | ESCC | protein methylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:000821314 | Esophagus | ESCC | protein alkylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:001802214 | Esophagus | ESCC | peptidyl-lysine methylation | 79/8552 | 131/18723 | 5.17e-04 | 2.86e-03 | 79 |
GO:00182056 | Oral cavity | OSCC | peptidyl-lysine modification | 216/7305 | 376/18723 | 2.32e-13 | 1.16e-11 | 216 |
GO:00064797 | Oral cavity | OSCC | protein methylation | 92/7305 | 181/18723 | 7.86e-04 | 4.26e-03 | 92 |
GO:00082137 | Oral cavity | OSCC | protein alkylation | 92/7305 | 181/18723 | 7.86e-04 | 4.26e-03 | 92 |
GO:00434142 | Oral cavity | OSCC | macromolecule methylation | 149/7305 | 316/18723 | 1.82e-03 | 8.60e-03 | 149 |
GO:00322591 | Oral cavity | OSCC | methylation | 168/7305 | 364/18723 | 3.03e-03 | 1.31e-02 | 168 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
METTL22 | SNV | Missense_Mutation | novel | c.1021A>G | p.Thr341Ala | p.T341A | Q9BUU2 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
METTL22 | SNV | Missense_Mutation | c.389N>T | p.Ala130Val | p.A130V | Q9BUU2 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
METTL22 | SNV | Missense_Mutation | c.413N>T | p.Gly138Val | p.G138V | Q9BUU2 | protein_coding | tolerated(0.16) | benign(0.277) | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
METTL22 | SNV | Missense_Mutation | rs754423164 | c.1112G>A | p.Arg371His | p.R371H | Q9BUU2 | protein_coding | tolerated(0.09) | possibly_damaging(0.593) | TCGA-D7-A6EV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
METTL22 | SNV | Missense_Mutation | c.493C>A | p.Pro165Thr | p.P165T | Q9BUU2 | protein_coding | tolerated(0.72) | benign(0.007) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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